I-Mutant2.0

Last Update 27/12/06



        
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**                                                                       **
**                             I-Mutant v2.0                             **
**         Predictor of Protein Stability Changes upon Mutations         **
**                                                                       **
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      SEQ File: fileseq.txt

      Position   WT  NEW     DDG    pH    T
            26    Q    V    0.52   7.0   55
            26    Q    L    0.76   7.0   55
            26    Q    I    0.93   7.0   55
            26    Q    M   -0.71   7.0   55
            26    Q    F    0.08   7.0   55
            26    Q    W    0.11   7.0   55
            26    Q    Y    0.18   7.0   55
            26    Q    G   -1.07   7.0   55
            26    Q    A    0.04   7.0   55
            26    Q    P   -0.96   7.0   55
            26    Q    S   -0.54   7.0   55
            26    Q    T   -0.40   7.0   55
            26    Q    C    1.10   7.0   55
            26    Q    H   -1.23   7.0   55
            26    Q    R   -0.79   7.0   55
            26    Q    K   -0.45   7.0   55
            26    Q    E    0.30   7.0   55
            26    Q    N   -2.35   7.0   55
            26    Q    D   -0.10   7.0   55


      WT:  Aminoacid in Wild-Type Protein
      NEW: New Aminoacid after Mutation
      DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
             DDG<0: Decrease Stability
             DDG>0: Increase Stability
      T:   Temperature in Celsius degrees
      pH:  -log[H+]



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*                                                                         *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting  *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310.                                         *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
*                                                                         *
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