I-Mutant2.0

Last Update 27/12/06



        
***************************************************************************
**                                                                       **
**                             I-Mutant v2.0                             **
**         Predictor of Protein Stability Changes upon Mutations         **
**                                                                       **
***************************************************************************


      SEQ File: fileseq.txt

      Position   WT  NEW     DDG    pH    T
           340    V    L    0.19   7.0   25
           340    V    I   -0.25   7.0   25
           340    V    M   -1.53   7.0   25
           340    V    F   -2.25   7.0   25
           340    V    W   -1.24   7.0   25
           340    V    Y   -1.87   7.0   25
           340    V    G   -3.47   7.0   25
           340    V    A   -1.90   7.0   25
           340    V    P   -2.08   7.0   25
           340    V    S   -2.24   7.0   25
           340    V    T   -1.52   7.0   25
           340    V    C   -0.45   7.0   25
           340    V    H   -1.09   7.0   25
           340    V    R   -2.10   7.0   25
           340    V    K   -2.44   7.0   25
           340    V    Q   -1.58   7.0   25
           340    V    E   -0.98   7.0   25
           340    V    N   -2.89   7.0   25
           340    V    D   -1.31   7.0   25


      WT:  Aminoacid in Wild-Type Protein
      NEW: New Aminoacid after Mutation
      DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
             DDG<0: Decrease Stability
             DDG>0: Increase Stability
      T:   Temperature in Celsius degrees
      pH:  -log[H+]



***************************************************************************
*                                                                         *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting  *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310.                                         *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
*                                                                         *
***************************************************************************