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** **
** I-Mutant v2.0 **
** Predictor of Protein Stability Changes upon Mutations **
** **
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PDB File: pdb8fx5.ent Chain: R
Position WT NEW DDG pH T RSA
65 T V -0.76 7.0 25 28.8
65 T L -1.02 7.0 25 28.8
65 T I -0.78 7.0 25 28.8
65 T M -0.47 7.0 25 28.8
65 T F 0.27 7.0 25 28.8
65 T W -0.39 7.0 25 28.8
65 T Y 0.12 7.0 25 28.8
65 T G -1.85 7.0 25 28.8
65 T A -1.40 7.0 25 28.8
65 T P -2.37 7.0 25 28.8
65 T S -0.69 7.0 25 28.8
65 T C -0.75 7.0 25 28.8
65 T H -1.75 7.0 25 28.8
65 T R -0.52 7.0 25 28.8
65 T K -1.08 7.0 25 28.8
65 T Q -1.41 7.0 25 28.8
65 T E -0.81 7.0 25 28.8
65 T N -0.96 7.0 25 28.8
65 T D -0.02 7.0 25 28.8
WT: Aminoacid in Wild-Type Protein
NEW: New Aminoacid after Mutation
DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
DDG<0: Decrease Stability
DDG>0: Increase Stability
T: Temperature in Celsius degrees
pH: -log[H+]
RSA: Relative Solvent Accessible Area
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* *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310. *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
* *
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