I-Mutant2.0

Last Update 27/12/06



        
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**                                                                       **
**                             I-Mutant v2.0                             **
**         Predictor of Protein Stability Changes upon Mutations         **
**                                                                       **
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      SEQ File: fileseq.txt

      Position   WT  NEW     DDG    pH    T
            13    L    V   -0.81   5.0   60
            13    L    I   -0.20   5.0   60
            13    L    M    0.11   5.0   60
            13    L    F    0.19   5.0   60
            13    L    W    0.41   5.0   60
            13    L    Y   -0.23   5.0   60
            13    L    G   -3.53   5.0   60
            13    L    A   -2.34   5.0   60
            13    L    P   -0.72   5.0   60
            13    L    S   -2.38   5.0   60
            13    L    T   -2.62   5.0   60
            13    L    C   -2.14   5.0   60
            13    L    H   -1.58   5.0   60
            13    L    R   -1.83   5.0   60
            13    L    K   -2.17   5.0   60
            13    L    Q   -1.52   5.0   60
            13    L    E   -0.75   5.0   60
            13    L    N   -2.46   5.0   60
            13    L    D   -3.14   5.0   60


      WT:  Aminoacid in Wild-Type Protein
      NEW: New Aminoacid after Mutation
      DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
             DDG<0: Decrease Stability
             DDG>0: Increase Stability
      T:   Temperature in Celsius degrees
      pH:  -log[H+]



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*                                                                         *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting  *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310.                                         *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
*                                                                         *
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