I-Mutant2.0

Last Update 27/12/06



        
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**                                                                       **
**                             I-Mutant v2.0                             **
**         Predictor of Protein Stability Changes upon Mutations         **
**                                                                       **
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      SEQ File: fileseq.txt

      Position   WT  NEW     DDG    pH    T
           266    T    V    0.27   7.0   25
           266    T    L   -0.53   7.0   25
           266    T    I   -0.69   7.0   25
           266    T    M   -0.37   7.0   25
           266    T    F    0.20   7.0   25
           266    T    W    0.04   7.0   25
           266    T    Y    0.89   7.0   25
           266    T    G   -2.16   7.0   25
           266    T    A   -1.26   7.0   25
           266    T    P   -1.68   7.0   25
           266    T    S   -0.57   7.0   25
           266    T    C   -0.87   7.0   25
           266    T    H   -1.45   7.0   25
           266    T    R   -0.44   7.0   25
           266    T    K   -1.01   7.0   25
           266    T    Q   -1.44   7.0   25
           266    T    E    0.18   7.0   25
           266    T    N   -0.41   7.0   25
           266    T    D    0.39   7.0   25


      WT:  Aminoacid in Wild-Type Protein
      NEW: New Aminoacid after Mutation
      DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
             DDG<0: Decrease Stability
             DDG>0: Increase Stability
      T:   Temperature in Celsius degrees
      pH:  -log[H+]



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*                                                                         *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting  *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310.                                         *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
*                                                                         *
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