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** **
** I-Mutant v2.0 **
** Predictor of Protein Stability Changes upon Mutations **
** **
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PDB File: pdb7sh6.ent Chain: _
Position WT NEW DDG pH T RSA
47 A V -0.06 8.0 50 57.2
47 A L 0.37 8.0 50 57.2
47 A I 0.07 8.0 50 57.2
47 A M 0.06 8.0 50 57.2
47 A F -0.38 8.0 50 57.2
47 A W -0.21 8.0 50 57.2
47 A Y -0.22 8.0 50 57.2
47 A G -0.68 8.0 50 57.2
47 A P -0.58 8.0 50 57.2
47 A S 0.56 8.0 50 57.2
47 A T -0.19 8.0 50 57.2
47 A C 0.02 8.0 50 57.2
47 A H -0.13 8.0 50 57.2
47 A R -0.03 8.0 50 57.2
47 A K -0.52 8.0 50 57.2
47 A Q 0.00 8.0 50 57.2
47 A E -0.39 8.0 50 57.2
47 A N -0.26 8.0 50 57.2
47 A D -0.28 8.0 50 57.2
WT: Aminoacid in Wild-Type Protein
NEW: New Aminoacid after Mutation
DDG: DG(NewProtein)-DG(WildType) in Kcal/mol
DDG<0: Decrease Stability
DDG>0: Increase Stability
T: Temperature in Celsius degrees
pH: -log[H+]
RSA: Relative Solvent Accessible Area
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* *
* Capriotti E, Fariselli P and Casadio R (2005). I-Mutant2.0: predicting *
* stability changes upon mutation from the protein sequence or structure. *
* Nucl. Acids Res. 33: W306-W310. *
* http://gpcr.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi *
* *
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