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10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": "7490748", "STATE": "2", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "CI2", "SOURCE": "Hordeum vulgare", "LENGTH": 83.0, "UniProt": "P01053", "PDB_wild": "1coa", "MUTATED_CHAIN": "I", "PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], "MUTATION_UNIPROT": "R63A,D65A", "MUTATION_PDB": "R62A,D64A", "SEC_STR": "Coil,Coil", "RSA": "53.6,23.3", "T": 25.0, "pH": 6.25, "BUFFER_NAME": "MES", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.9, "dln(kf)_H2O": -0.13, "ln(ku)_H2O": -6.37, "dln(ku)_H2O": 2.67, "dGKIN_H2O": 25.44, "mf": -6.32, "mu": 2.9, "AUTHOR_KIN": "Itzhaki LS, Otzen DE, Fersht AR", "REFERENCE_KIN": "The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding, J Mol Biol. 254(2):260-288. doi: 10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, 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10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": "7490748", "STATE": "2", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "CI2", "SOURCE": "Hordeum vulgare", "LENGTH": 83.0, "UniProt": "P01053", "PDB_wild": "1coa", "MUTATED_CHAIN": "I", "PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], "MUTATION_UNIPROT": "E34Q", "MUTATION_PDB": "E33Q", "SEC_STR": "Helix", "RSA": "71.6", "T": 25.0, "pH": 6.25, "BUFFER_NAME": "MES", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.43, "dln(kf)_H2O": -0.6, "ln(ku)_H2O": -8.97, "dln(ku)_H2O": 0.07, "dGKIN_H2O": 30.72, "mf": -5.1, "mu": 3.27, "AUTHOR_KIN": "Itzhaki LS, Otzen DE, Fersht AR", "REFERENCE_KIN": "The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding, J Mol Biol. 254(2):260-288. doi: 10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": 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"PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], "MUTATION_UNIPROT": "I50A", "MUTATION_PDB": "I49A", "SEC_STR": "Beta", "RSA": "42.6", "T": 25.0, "pH": 6.25, "BUFFER_NAME": "MES", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.94, "dln(kf)_H2O": -1.09, "ln(ku)_H2O": -7.5, "dln(ku)_H2O": 1.54, "dGKIN_H2O": 25.87, "mf": -7.18, "mu": 3.1, "AUTHOR_KIN": "Itzhaki LS, Otzen DE, Fersht AR", "REFERENCE_KIN": "The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding, J Mol Biol. 254(2):260-288. doi: 10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": "7490748", "STATE": "2", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "CI2", "SOURCE": "Hordeum vulgare", "LENGTH": 83.0, "UniProt": "P01053", "PDB_wild": "1coa", "MUTATED_CHAIN": "I", "PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], 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10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": "7490748", "STATE": "2", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "CI2", "SOURCE": "Hordeum vulgare", "LENGTH": 83.0, "UniProt": "P01053", "PDB_wild": "1coa", "MUTATED_CHAIN": "I", "PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], "MUTATION_UNIPROT": "L52V,F70L", "MUTATION_PDB": "L51V,F69L", "SEC_STR": "Beta,Beta", "RSA": "23.8,16.2", "T": 25.0, "pH": 6.25, "BUFFER_NAME": "MES", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.18, "dln(kf)_H2O": -0.85, "ln(ku)_H2O": -6.17, "dln(ku)_H2O": 2.87, "dGKIN_H2O": 23.17, "mf": -5.85, "mu": 3.1, "AUTHOR_KIN": "Itzhaki LS, Otzen DE, Fersht AR", "REFERENCE_KIN": "The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding, J Mol Biol. 254(2):260-288. doi: 10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, 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"PFAM": [ "PF00280" ], "CATH": [ "1coaI00 (3.30.10.10)" ], "MUTATION_UNIPROT": "L52A,F70A", "MUTATION_PDB": "L51A,F69A", "SEC_STR": "Beta,Beta", "RSA": "23.8,16.2", "T": 25.0, "pH": 6.25, "BUFFER_NAME": "MES", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 1.84, "dln(kf)_H2O": -2.19, "ln(ku)_H2O": -3.65, "dln(ku)_H2O": 5.39, "dGKIN_H2O": 13.6, "mf": -7.04, "mu": 2.6, "AUTHOR_KIN": "Itzhaki LS, Otzen DE, Fersht AR", "REFERENCE_KIN": "The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding, J Mol Biol. 254(2):260-288. doi: 10.1006/jmbi.1995.0616.", "YEAR_KIN": 1995.0, "PMID_KIN": "7490748", "STATE": "2", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "CI2", "SOURCE": "Hordeum vulgare", "LENGTH": 83.0, "UniProt": "P01053", "PDB_wild": "1coa", "MUTATED_CHAIN": "I", "PFAM": [ "PF00280" ], "CATH": [ "1coaI00 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