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J Mol Biol 320(2):389-402. https://doi.org/10.1016/S0022-2836(02)00445-X", "YEAR_KIN": 2002.0, "PMID_KIN": "12079394", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 62.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "G128A,S124K", "MUTATION_PDB": "G128A,S124K", "SEC_STR": "Coil,Beta", "RSA": "31.0,0.8", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -6.62, "mu": 1.59, "beta-T": 0.81, "AUTHOR_KIN": "Northey JGB, Maxwell KL, Davidson AR", "REFERENCE_KIN": "Protein folding kinetics beyond the phi value: using multiple amino acid substitutions to investigate the structure of the SH3 domain folding transition state. J Mol Biol 320(2):389-402. https://doi.org/10.1016/S0022-2836(02)00445-X", "YEAR_KIN": 2002.0, "PMID_KIN": "12079394", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.41, "ln(ku)_H2O": -0.67, "mf": -8.83, "mu": 3.43, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb748", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.41, "ln(ku)_H2O": -0.67, "mf": -8.83, "mu": 3.43, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb748", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "F87S", "MUTATION_PDB": "F87S", "SEC_STR": "Beta", "RSA": "17.8", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.7, "dln(kf)_H2O": -0.71, "ln(ku)_H2O": 1.95, "dln(ku)_H2O": 2.62, "ddGKIN_H2O": -8.2, "mf": -7.49, "mu": 1.88, "PhiF_H2O": 0.21, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb754", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A89G", "MUTATION_PDB": "A89G", "SEC_STR": "Beta", "RSA": "2.8", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.92, "dln(kf)_H2O": -0.49, "ln(ku)_H2O": 1.48, "dln(ku)_H2O": 2.15, "ddGKIN_H2O": -6.53, "mf": -8.37, "mu": 2.8, "PhiF_H2O": 0.18, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb755", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A89L,F103L", "MUTATION_PDB": "A89L,F103L", "SEC_STR": "Beta,Beta", "RSA": "2.8,2.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.95, "dln(kf)_H2O": 0.54, "ln(ku)_H2O": 4.52, "dln(ku)_H2O": 5.19, "ddGKIN_H2O": -11.55, "mf": -6.28, "mu": 2.72, "PhiF_H2O": -0.11, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb755", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "L101V", "MUTATION_PDB": "L101V", "SEC_STR": "Coil", "RSA": "4.9", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.23, "dln(kf)_H2O": -0.18, "ln(ku)_H2O": 1.9, "dln(ku)_H2O": 2.57, "ddGKIN_H2O": -6.82, "mf": -8.95, "mu": 3.89, "PhiF_H2O": 0.06, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb756", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "L101I", "MUTATION_PDB": "L101I", "SEC_STR": "Coil", "RSA": "4.9", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.49, "dln(kf)_H2O": 0.08, "ln(ku)_H2O": 0.59, "dln(ku)_H2O": 1.26, "ddGKIN_H2O": -2.89, "mf": -8.66, "mu": 4.14, "PhiF_H2O": -0.07, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb770", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122S", "MUTATION_PDB": "A122S", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 0.83, "dln(kf)_H2O": -2.58, "ln(ku)_H2O": 1.06, "dln(ku)_H2O": 1.73, "ddGKIN_H2O": -10.63, "mf": -9.67, "mu": 3.68, "PhiF_H2O": 0.6, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb771", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122G", "MUTATION_PDB": "A122G", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 1.46, "dln(kf)_H2O": -1.95, "ln(ku)_H2O": -0.36, "dln(ku)_H2O": 0.31, "ddGKIN_H2O": -5.65, "mf": -8.95, "mu": 3.56, "PhiF_H2O": 0.86, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb773", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122L", "MUTATION_PDB": "A122L", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 1.87, "dln(kf)_H2O": -1.54, "ln(ku)_H2O": 1.84, "dln(ku)_H2O": 2.51, "ddGKIN_H2O": -10.0, "mf": -8.66, "mu": 3.56, "PhiF_H2O": 0.38, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb776", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "I133V", "MUTATION_PDB": "I133V", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.17, "dln(kf)_H2O": -0.24, "ln(ku)_H2O": -0.87, "dln(ku)_H2O": -0.2, "ddGKIN_H2O": -0.17, "mf": -8.91, "mu": 2.76, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb777", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "I133L", "MUTATION_PDB": "I133L", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.87, "dln(kf)_H2O": -0.54, "ln(ku)_H2O": 0.1, "dln(ku)_H2O": 0.77, "ddGKIN_H2O": -3.14, "mf": -8.54, "mu": 3.26, "PhiF_H2O": 0.42, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb778", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "I133L", "MUTATION_PDB": "I133L", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.87, "dln(kf)_H2O": -0.54, "ln(ku)_H2O": 0.1, "dln(ku)_H2O": 0.77, "ddGKIN_H2O": -3.14, "mf": -8.54, "mu": 3.26, "PhiF_H2O": 0.42, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb778", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "I133F", "MUTATION_PDB": "I133F", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.28, "dln(kf)_H2O": -0.13, "ln(ku)_H2O": 5.08, "dln(ku)_H2O": 5.75, "ddGKIN_H2O": -14.52, "mf": -7.45, "mu": 3.39, "PhiF_H2O": 0.02, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb779", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "I133F", "MUTATION_PDB": "I133F", "SEC_STR": "Beta", "RSA": "0.0", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.28, "dln(kf)_H2O": -0.13, "ln(ku)_H2O": 5.08, "dln(ku)_H2O": 5.75, "ddGKIN_H2O": -14.52, "mf": -7.45, "mu": 3.39, "PhiF_H2O": 0.02, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb779", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "V138A", "MUTATION_PDB": "V138A", "SEC_STR": "Beta", "RSA": "9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.37, "dln(kf)_H2O": -0.04, "ln(ku)_H2O": 2.89, "dln(ku)_H2O": 3.56, "ddGKIN_H2O": -8.91, "mf": -8.16, "mu": 4.02, "PhiF_H2O": 0.01, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb780", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "V138I", "MUTATION_PDB": "V138I", "SEC_STR": "Beta", "RSA": "9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.96, "dln(kf)_H2O": 0.55, "ln(ku)_H2O": -0.42, "dln(ku)_H2O": 0.25, "ddGKIN_H2O": 0.71, "mf": -9.08, "mu": 4.14, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb781", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "V138L", "MUTATION_PDB": "V138L", "SEC_STR": "Beta", "RSA": "9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.99, "dln(kf)_H2O": 0.58, "ln(ku)_H2O": 0.11, "dln(ku)_H2O": 0.78, "ddGKIN_H2O": -0.5, "mf": -8.7, "mu": 4.31, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb782", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "V138L", "MUTATION_PDB": "V138L", "SEC_STR": "Beta", "RSA": "9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 3.99, "dln(kf)_H2O": 0.58, "ln(ku)_H2O": 0.11, "dln(ku)_H2O": 0.78, "ddGKIN_H2O": -0.5, "mf": -8.7, "mu": 4.31, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb784", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122V,V138I", "MUTATION_PDB": "A122V,V138I", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 6.06, "dln(kf)_H2O": 2.65, "ln(ku)_H2O": 0.99, "dln(ku)_H2O": 1.66, "ddGKIN_H2O": 2.26, "mf": -8.49, "mu": 4.77, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb785", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122V,V138I", "MUTATION_PDB": "A122V,V138I", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 6.06, "dln(kf)_H2O": 2.65, "ln(ku)_H2O": 0.99, "dln(ku)_H2O": 1.66, "ddGKIN_H2O": 2.26, "mf": -8.49, "mu": 4.77, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb785", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122G,V138L", "MUTATION_PDB": "A122G,V138L", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 1.72, "dln(kf)_H2O": -1.69, "ln(ku)_H2O": -0.78, "dln(ku)_H2O": -0.11, "ddGKIN_H2O": -3.93, "mf": -9.12, "mu": 3.1, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb786", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122V,V138L", "MUTATION_PDB": "A122V,V138L", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 5.81, "dln(kf)_H2O": 2.4, "ln(ku)_H2O": 1.59, "dln(ku)_H2O": 2.26, "ddGKIN_H2O": 0.29, "mf": -8.12, "mu": 4.6, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb787", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122V,V138L", "MUTATION_PDB": "A122V,V138L", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 5.81, "dln(kf)_H2O": 2.4, "ln(ku)_H2O": 1.59, "dln(ku)_H2O": 2.26, "ddGKIN_H2O": 0.29, "mf": -8.12, "mu": 4.6, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb787", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "A122G,V138F", "MUTATION_PDB": "A122G,V138F", "SEC_STR": "Beta,Beta", "RSA": "0.0,9.2", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "ln(kf)_H2O": 2.37, "dln(kf)_H2O": -1.04, "ln(ku)_H2O": 0.57, "dln(ku)_H2O": 1.24, "ddGKIN_H2O": -5.65, "mf": -10.25, "mu": 3.68, "AUTHOR_KIN": "Northey, J.G.B., Di Nardo, A.A., Davidson, A.R.", "REFERENCE_KIN": "Hydrophobic core packing in the SH3 domain folding transition state. Nat. Struct. 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Biol. 9, 126\u2013130. https://doi.org/10.1038/nsb789", "YEAR_KIN": 2002.0, "PMID_KIN": "11786916", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -4.41, "mu": 2.18, "AUTHOR_KIN": "Zarrine-Afsar A, Wallin S, Neculai AM, Neudecker P, Howell PL, Davidson AR, Chan HS", "REFERENCE_KIN": "Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. Proc Natl Acad Sci U S A 105(29): 9999\u201310004. https://doi.org/10.1073/pnas.0801874105", "YEAR_KIN": 2008.0, "PMID_KIN": "18626019", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -4.41, "mu": 2.18, "AUTHOR_KIN": "Zarrine-Afsar A, Wallin S, Neculai AM, Neudecker P, Howell PL, Davidson AR, Chan HS", "REFERENCE_KIN": "Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. Proc Natl Acad Sci U S A 105(29): 9999\u201310004. https://doi.org/10.1073/pnas.0801874105", "YEAR_KIN": 2008.0, "PMID_KIN": "18626019", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "N136A", "MUTATION_PDB": "N136A", "SEC_STR": "Helix", "RSA": "78.3", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -4.83, "mu": 2.25, "AUTHOR_KIN": "Zarrine-Afsar A, Wallin S, Neculai AM, Neudecker P, Howell PL, Davidson AR, Chan HS", "REFERENCE_KIN": "Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. Proc Natl Acad Sci U S A 105(29): 9999\u201310004. https://doi.org/10.1073/pnas.0801874105", "YEAR_KIN": 2008.0, "PMID_KIN": "18626019", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "N136A", "MUTATION_PDB": "N136A", "SEC_STR": "Helix", "RSA": "78.3", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -4.83, "mu": 2.25, "AUTHOR_KIN": "Zarrine-Afsar A, Wallin S, Neculai AM, Neudecker P, Howell PL, Davidson AR, Chan HS", "REFERENCE_KIN": "Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. Proc Natl Acad Sci U S A 105(29): 9999\u201310004. https://doi.org/10.1073/pnas.0801874105", "YEAR_KIN": 2008.0, "PMID_KIN": "18626019", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" }, { "PROTEIN": "Fyn SH3", "SOURCE": "Homo sapiens", "LENGTH": 59.0, "UniProt": "P06241", "PDB_wild": "1shf", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shfA00 (2.30.30.40)" ], "EC_NUMBER": "2.7.10.2", "MUTATION_UNIPROT": "N136I", "MUTATION_PDB": "N136I", "SEC_STR": "Helix", "RSA": "78.3", "T": 25.0, "pH": 8.0, "BUFFER_NAME": "Tris-HCl", "BUFFER_CONC": "0.01", "ADDITIVES": "0.2 mM EDTA", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "GuHCl", "mf": -4.73, "mu": 2.3, "AUTHOR_KIN": "Zarrine-Afsar A, Wallin S, Neculai AM, Neudecker P, Howell PL, Davidson AR, Chan HS", "REFERENCE_KIN": "Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. 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Protein Sci 18(3):526-36. https://doi.org/10.1002/pro.52", "YEAR_KIN": 2009.0, "PMID_KIN": "19241379", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-11T01:00:00" } ]