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Biol. 6, 1010\u20131016. https://doi.org/10.1038/14932", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.52, "ln(ku)_H2O": -2.53, "dGKIN_H2O": 12.5, "mf": -3.69, "mu": 1.29, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14932", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D1011G", "MUTATION_PDB": "D48G", "SEC_STR": "Coil", "RSA": "69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.34, "dln(kf)_H2O": 3.03, "ln(ku)_H2O": -4.51, "dln(ku)_H2O": 0.79, "dGKIN_H2O": 21.94, "ddGKIN_H2O": 5.57, "mf": -2.08, "mu": 1.06, "PhiF_H2O": 1.1, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14897", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D1011G", "MUTATION_PDB": "D48G", "SEC_STR": "Coil", "RSA": "69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.34, "dln(kf)_H2O": 3.03, "ln(ku)_H2O": -4.51, "dln(ku)_H2O": 0.79, "dGKIN_H2O": 21.94, "ddGKIN_H2O": 5.57, "mf": -2.08, "mu": 1.06, "PhiF_H2O": 1.1, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14897", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L971S,D1011G", "MUTATION_PDB": "L8S,D48G", "SEC_STR": "Beta,Coil", "RSA": "42.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.08, "dln(kf)_H2O": 2.77, "ln(ku)_H2O": -3.24, "dln(ku)_H2O": 2.06, "dGKIN_H2O": 18.14, "ddGKIN_H2O": -3.8, "mf": -2.06, "mu": 1.06, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14898", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L971S,D1011G", "MUTATION_PDB": "L8S,D48G", "SEC_STR": "Beta,Coil", "RSA": "42.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.08, "dln(kf)_H2O": 2.77, "ln(ku)_H2O": -3.24, "dln(ku)_H2O": 2.06, "dGKIN_H2O": 18.14, "ddGKIN_H2O": -3.8, "mf": -2.06, "mu": 1.06, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14898", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A974G,D1011G", "MUTATION_PDB": "A11G,D48G", "SEC_STR": "Beta,Coil", "RSA": "1.9,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.26, "dln(kf)_H2O": 2.95, "ln(ku)_H2O": -0.63, "dln(ku)_H2O": 4.67, "dGKIN_H2O": 12.13, "ddGKIN_H2O": -9.81, "mf": -2.3, "mu": 0.97, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14899", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A974G,D1011G", "MUTATION_PDB": "A11G,D48G", "SEC_STR": "Beta,Coil", "RSA": "1.9,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.26, "dln(kf)_H2O": 2.95, "ln(ku)_H2O": -0.63, "dln(ku)_H2O": 4.67, "dGKIN_H2O": 12.13, "ddGKIN_H2O": -9.81, "mf": -2.3, "mu": 0.97, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14899", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D977S", "MUTATION_PDB": "D14S", "SEC_STR": "Coil", "RSA": "49.1", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.06, "dln(kf)_H2O": -0.25, "ln(ku)_H2O": -3.96, "dln(ku)_H2O": 1.34, "dGKIN_H2O": 12.46, "ddGKIN_H2O": -3.91, "mf": -2.21, "mu": 1.04, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14900", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D977S", "MUTATION_PDB": "D14S", "SEC_STR": "Coil", "RSA": "49.1", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.06, "dln(kf)_H2O": -0.25, "ln(ku)_H2O": -3.96, "dln(ku)_H2O": 1.34, "dGKIN_H2O": 12.46, "ddGKIN_H2O": -3.91, "mf": -2.21, "mu": 1.04, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14900", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V986A,D1011G", "MUTATION_PDB": "V23A,D48G", "SEC_STR": "Coil,Coil", "RSA": "1.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.18, "dln(kf)_H2O": 1.87, "ln(ku)_H2O": -2.3, "dln(ku)_H2O": 3.0, "dGKIN_H2O": 13.58, "ddGKIN_H2O": -8.36, "mf": -1.88, "mu": 1.29, "PhiF_H2O": 0.32, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14901", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V986A,D1011G", "MUTATION_PDB": "V23A,D48G", "SEC_STR": "Coil,Coil", "RSA": "1.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.18, "dln(kf)_H2O": 1.87, "ln(ku)_H2O": -2.3, "dln(ku)_H2O": 3.0, "dGKIN_H2O": 13.58, "ddGKIN_H2O": -8.36, "mf": -1.88, "mu": 1.29, "PhiF_H2O": 0.32, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14901", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "T987A,D1011G", "MUTATION_PDB": "T24A,D48G", "SEC_STR": "Coil,Coil", "RSA": "39.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.81, "dln(kf)_H2O": 2.5, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 17.41, "ddGKIN_H2O": -4.53, "mf": -2.06, "mu": 1.06, "PhiF_H2O": 0.29, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14902", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "T987A,D1011G", "MUTATION_PDB": "T24A,D48G", "SEC_STR": "Coil,Coil", "RSA": "39.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.81, "dln(kf)_H2O": 2.5, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 17.41, "ddGKIN_H2O": -4.53, "mf": -2.06, "mu": 1.06, "PhiF_H2O": 0.29, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14902", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D992A,D1011G", "MUTATION_PDB": "D29A,D48G", "SEC_STR": "Coil,Coil", "RSA": "33.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.89, "dln(kf)_H2O": 2.58, "ln(ku)_H2O": -3.0, "dln(ku)_H2O": 2.3, "dGKIN_H2O": 17.06, "ddGKIN_H2O": -4.88, "mf": -2.28, "mu": 1.14, "PhiF_H2O": 0.22, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14903", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D992A,D1011G", "MUTATION_PDB": "D29A,D48G", "SEC_STR": "Coil,Coil", "RSA": "33.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.89, "dln(kf)_H2O": 2.58, "ln(ku)_H2O": -3.0, "dln(ku)_H2O": 2.3, "dGKIN_H2O": 17.06, "ddGKIN_H2O": -4.88, "mf": -2.28, "mu": 1.14, "PhiF_H2O": 0.22, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14903", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L996V,D1011G", "MUTATION_PDB": "L33V,D48G", "SEC_STR": "Beta,Coil", "RSA": "6.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.85, "dln(kf)_H2O": 3.54, "ln(ku)_H2O": -2.21, "dln(ku)_H2O": 3.09, "dGKIN_H2O": 17.49, "ddGKIN_H2O": -4.45, "mf": -1.93, "mu": 1.16, "PhiF_H2O": -0.2, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14904", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L996V,D1011G", "MUTATION_PDB": "L33V,D48G", "SEC_STR": "Beta,Coil", "RSA": "6.1,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.85, "dln(kf)_H2O": 3.54, "ln(ku)_H2O": -2.21, "dln(ku)_H2O": 3.09, "dGKIN_H2O": 17.49, "ddGKIN_H2O": -4.45, "mf": -1.93, "mu": 1.16, "PhiF_H2O": -0.2, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14904", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "S999N,D1011G", "MUTATION_PDB": "S36N,D48G", "SEC_STR": "Coil,Coil", "RSA": "34.6,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.87, "dln(kf)_H2O": 2.56, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 17.57, "ddGKIN_H2O": -4.37, "mf": -2.28, "mu": 0.89, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14905", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "S999N,D1011G", "MUTATION_PDB": "S36N,D48G", "SEC_STR": "Coil,Coil", "RSA": "34.6,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.87, "dln(kf)_H2O": 2.56, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 17.57, "ddGKIN_H2O": -4.37, "mf": -2.28, "mu": 0.89, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14905", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "K1006A,D1011G", "MUTATION_PDB": "K43A,D48G", "SEC_STR": "Beta,Coil", "RSA": "31.2,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.91, "dln(kf)_H2O": 2.6, "ln(ku)_H2O": -3.32, "dln(ku)_H2O": 1.98, "dGKIN_H2O": 17.93, "ddGKIN_H2O": -4.01, "mf": -2.13, "mu": 1.06, "PhiF_H2O": 0.26, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14906", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "K1006A,D1011G", "MUTATION_PDB": "K43A,D48G", "SEC_STR": "Beta,Coil", "RSA": "31.2,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.91, "dln(kf)_H2O": 2.6, "ln(ku)_H2O": -3.32, "dln(ku)_H2O": 1.98, "dGKIN_H2O": 17.93, "ddGKIN_H2O": -4.01, "mf": -2.13, "mu": 1.06, "PhiF_H2O": 0.26, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14906", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1007A,D1011G", "MUTATION_PDB": "V44A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.61, "dln(kf)_H2O": 0.3, "ln(ku)_H2O": -1.51, "dln(ku)_H2O": 3.79, "dGKIN_H2O": 7.74, "ddGKIN_H2O": -14.2, "mf": -2.63, "mu": 1.04, "PhiF_H2O": 0.48, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14907", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1007A,D1011G", "MUTATION_PDB": "V44A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.61, "dln(kf)_H2O": 0.3, "ln(ku)_H2O": -1.51, "dln(ku)_H2O": 3.79, "dGKIN_H2O": 7.74, "ddGKIN_H2O": -14.2, "mf": -2.63, "mu": 1.04, "PhiF_H2O": 0.48, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14907", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1009A,D1011G", "MUTATION_PDB": "V46A,D48G", "SEC_STR": "Beta,Coil", "RSA": "12.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.42, "dln(kf)_H2O": 1.11, "ln(ku)_H2O": -4.96, "dln(ku)_H2O": 0.34, "dGKIN_H2O": 18.3, "ddGKIN_H2O": -3.64, "mf": -2.21, "mu": 1.06, "PhiF_H2O": 1.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14908", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1009A,D1011G", "MUTATION_PDB": "V46A,D48G", "SEC_STR": "Beta,Coil", "RSA": "12.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.42, "dln(kf)_H2O": 1.11, "ln(ku)_H2O": -4.96, "dln(ku)_H2O": 0.34, "dGKIN_H2O": 18.3, "ddGKIN_H2O": -3.64, "mf": -2.21, "mu": 1.06, "PhiF_H2O": 1.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14908", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "N1010G", "MUTATION_PDB": "N47G", "SEC_STR": "Coil", "RSA": "93.6", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.69, "dln(kf)_H2O": 0.38, "ln(ku)_H2O": -5.52, "dln(ku)_H2O": -0.22, "dGKIN_H2O": 17.86, "ddGKIN_H2O": 1.49, "mf": -2.21, "mu": 1.06, "PhiF_H2O": 0.63, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14909", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "N1010G", "MUTATION_PDB": "N47G", "SEC_STR": "Coil", "RSA": "93.6", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.69, "dln(kf)_H2O": 0.38, "ln(ku)_H2O": -5.52, "dln(ku)_H2O": -0.22, "dGKIN_H2O": 17.86, "ddGKIN_H2O": 1.49, "mf": -2.21, "mu": 1.06, "PhiF_H2O": 0.63, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14909", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "F1015A,D1011G", "MUTATION_PDB": "F52A,D48G", "SEC_STR": "Beta,Coil", "RSA": "28.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.7, "dln(kf)_H2O": 0.39, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": 2.64, "dGKIN_H2O": 10.81, "ddGKIN_H2O": -11.13, "mf": -2.48, "mu": 0.84, "PhiF_H2O": 0.58, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14910", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "F1015A,D1011G", "MUTATION_PDB": "F52A,D48G", "SEC_STR": "Beta,Coil", "RSA": "28.4,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.7, "dln(kf)_H2O": 0.39, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": 2.64, "dGKIN_H2O": 10.81, "ddGKIN_H2O": -11.13, "mf": -2.48, "mu": 0.84, "PhiF_H2O": 0.58, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14910", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1016A,D1011G", "MUTATION_PDB": "V53A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.08, "dln(kf)_H2O": 0.77, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 13.13, "ddGKIN_H2O": -8.81, "mf": -2.3, "mu": 1.19, "PhiF_H2O": 0.61, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14911", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1016A,D1011G", "MUTATION_PDB": "V53A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.08, "dln(kf)_H2O": 0.77, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 13.13, "ddGKIN_H2O": -8.81, "mf": -2.3, "mu": 1.19, "PhiF_H2O": 0.61, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14911", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A1018G,D1011G", "MUTATION_PDB": "A55G,D48G", "SEC_STR": "Helix,Coil", "RSA": "13.2,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.56, "dln(kf)_H2O": 1.25, "ln(ku)_H2O": -3.0, "dln(ku)_H2O": 2.3, "dGKIN_H2O": 13.76, "ddGKIN_H2O": -8.18, "mf": -2.38, "mu": 1.04, "PhiF_H2O": 0.53, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14912", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A1018G,D1011G", "MUTATION_PDB": "A55G,D48G", "SEC_STR": "Helix,Coil", "RSA": "13.2,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.56, "dln(kf)_H2O": 1.25, "ln(ku)_H2O": -3.0, "dln(ku)_H2O": 2.3, "dGKIN_H2O": 13.76, "ddGKIN_H2O": -8.18, "mf": -2.38, "mu": 1.04, "PhiF_H2O": 0.53, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14912", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1021A,D1011G", "MUTATION_PDB": "V58A,D48G", "SEC_STR": "Beta,Coil", "RSA": "8.5,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.71, "dln(kf)_H2O": 2.4, "ln(ku)_H2O": -1.14, "dln(ku)_H2O": 4.16, "dGKIN_H2O": 12.02, "ddGKIN_H2O": -9.92, "mf": -2.38, "mu": 1.11, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14913", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1021A,D1011G", "MUTATION_PDB": "V58A,D48G", "SEC_STR": "Beta,Coil", "RSA": "8.5,69.3", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.71, "dln(kf)_H2O": 2.4, "ln(ku)_H2O": -1.14, "dln(ku)_H2O": 4.16, "dGKIN_H2O": 12.02, "ddGKIN_H2O": -9.92, "mf": -2.38, "mu": 1.11, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14913", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D1011G", "MUTATION_PDB": "D48G", "SEC_STR": "Coil", "RSA": "69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.91, "dln(kf)_H2O": 1.39, "ln(ku)_H2O": -2.53, "dGKIN_H2O": 15.95, "ddGKIN_H2O": 3.45, "mf": -2.97, "mu": 1.24, "PhiF_H2O": 1.0, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14933", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D1011G", "MUTATION_PDB": "D48G", "SEC_STR": "Coil", "RSA": "69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.91, "dln(kf)_H2O": 1.39, "ln(ku)_H2O": -2.53, "dGKIN_H2O": 15.95, "ddGKIN_H2O": 3.45, "mf": -2.97, "mu": 1.24, "PhiF_H2O": 1.0, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14933", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L971S,D1011G", "MUTATION_PDB": "L8S,D48G", "SEC_STR": "Beta,Coil", "RSA": "42.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.81, "dln(kf)_H2O": 1.29, "ln(ku)_H2O": -1.27, "dln(ku)_H2O": 1.26, "dGKIN_H2O": 12.59, "ddGKIN_H2O": -3.36, "mf": -3.39, "mu": 1.19, "PhiF_H2O": 0.07, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14934", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L971S,D1011G", "MUTATION_PDB": "L8S,D48G", "SEC_STR": "Beta,Coil", "RSA": "42.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.81, "dln(kf)_H2O": 1.29, "ln(ku)_H2O": -1.27, "dln(ku)_H2O": 1.26, "dGKIN_H2O": 12.59, "ddGKIN_H2O": -3.36, "mf": -3.39, "mu": 1.19, "PhiF_H2O": 0.07, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14934", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A974G,D1011G", "MUTATION_PDB": "A11G,D48G", "SEC_STR": "Beta,Coil", "RSA": "1.9,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.76, "dln(kf)_H2O": 1.24, "ln(ku)_H2O": 0.34, "dln(ku)_H2O": 2.87, "dGKIN_H2O": 8.47, "ddGKIN_H2O": -7.48, "mf": -3.12, "mu": 1.26, "PhiF_H2O": 0.05, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14935", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A974G,D1011G", "MUTATION_PDB": "A11G,D48G", "SEC_STR": "Beta,Coil", "RSA": "1.9,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.76, "dln(kf)_H2O": 1.24, "ln(ku)_H2O": 0.34, "dln(ku)_H2O": 2.87, "dGKIN_H2O": 8.47, "ddGKIN_H2O": -7.48, "mf": -3.12, "mu": 1.26, "PhiF_H2O": 0.05, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14935", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D977S", "MUTATION_PDB": "D14S", "SEC_STR": "Coil", "RSA": "49.1", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.44, "dln(kf)_H2O": -0.08, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": -0.13, "dGKIN_H2O": 12.64, "ddGKIN_H2O": 0.14, "mf": -2.97, "mu": 1.39, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14936", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D977S", "MUTATION_PDB": "D14S", "SEC_STR": "Coil", "RSA": "49.1", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.44, "dln(kf)_H2O": -0.08, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": -0.13, "dGKIN_H2O": 12.64, "ddGKIN_H2O": 0.14, "mf": -2.97, "mu": 1.39, "PhiF_H2O": 0.16, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14936", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V986A,D1011G", "MUTATION_PDB": "V23A,D48G", "SEC_STR": "Coil,Coil", "RSA": "1.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.18, "dln(kf)_H2O": 0.66, "ln(ku)_H2O": -0.51, "dln(ku)_H2O": 2.02, "dGKIN_H2O": 9.14, "ddGKIN_H2O": -6.81, "mf": -3.42, "mu": 1.36, "PhiF_H2O": 0.27, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14937", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V986A,D1011G", "MUTATION_PDB": "V23A,D48G", "SEC_STR": "Coil,Coil", "RSA": "1.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.18, "dln(kf)_H2O": 0.66, "ln(ku)_H2O": -0.51, "dln(ku)_H2O": 2.02, "dGKIN_H2O": 9.14, "ddGKIN_H2O": -6.81, "mf": -3.42, "mu": 1.36, "PhiF_H2O": 0.27, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14937", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "T987A,D1011G", "MUTATION_PDB": "T24A,D48G", "SEC_STR": "Coil,Coil", "RSA": "39.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.5, "dln(kf)_H2O": 0.98, "ln(ku)_H2O": -1.24, "dln(ku)_H2O": 1.29, "dGKIN_H2O": 11.73, "ddGKIN_H2O": -4.22, "mf": -2.82, "mu": 1.24, "PhiF_H2O": 0.24, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14938", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "T987A,D1011G", "MUTATION_PDB": "T24A,D48G", "SEC_STR": "Coil,Coil", "RSA": "39.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.5, "dln(kf)_H2O": 0.98, "ln(ku)_H2O": -1.24, "dln(ku)_H2O": 1.29, "dGKIN_H2O": 11.73, "ddGKIN_H2O": -4.22, "mf": -2.82, "mu": 1.24, "PhiF_H2O": 0.24, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14938", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D992A,D1011G", "MUTATION_PDB": "D29A,D48G", "SEC_STR": "Coil,Coil", "RSA": "33.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.61, "dln(kf)_H2O": 1.09, "ln(ku)_H2O": -1.66, "dln(ku)_H2O": 0.87, "dGKIN_H2O": 13.06, "ddGKIN_H2O": -2.89, "mf": -3.12, "mu": 1.54, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14939", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "D992A,D1011G", "MUTATION_PDB": "D29A,D48G", "SEC_STR": "Coil,Coil", "RSA": "33.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.61, "dln(kf)_H2O": 1.09, "ln(ku)_H2O": -1.66, "dln(ku)_H2O": 0.87, "dGKIN_H2O": 13.06, "ddGKIN_H2O": -2.89, "mf": -3.12, "mu": 1.54, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14939", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L996V,D1011G", "MUTATION_PDB": "L33V,D48G", "SEC_STR": "Beta,Coil", "RSA": "6.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.44, "dln(kf)_H2O": 1.92, "ln(ku)_H2O": -0.45, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 12.11, "ddGKIN_H2O": -3.84, "mf": -3.1, "mu": 1.21, "PhiF_H2O": -0.3, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14940", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "L996V,D1011G", "MUTATION_PDB": "L33V,D48G", "SEC_STR": "Beta,Coil", "RSA": "6.1,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 4.44, "dln(kf)_H2O": 1.92, "ln(ku)_H2O": -0.45, "dln(ku)_H2O": 2.08, "dGKIN_H2O": 12.11, "ddGKIN_H2O": -3.84, "mf": -3.1, "mu": 1.21, "PhiF_H2O": -0.3, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14940", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "S999N,D1011G", "MUTATION_PDB": "S36N,D48G", "SEC_STR": "Coil,Coil", "RSA": "34.6,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.78, "dln(kf)_H2O": 1.26, "ln(ku)_H2O": -1.61, "dln(ku)_H2O": 0.92, "dGKIN_H2O": 13.36, "ddGKIN_H2O": -2.59, "mf": -2.92, "mu": 1.24, "PhiF_H2O": 0.12, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14941", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "S999N,D1011G", "MUTATION_PDB": "S36N,D48G", "SEC_STR": "Coil,Coil", "RSA": "34.6,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.78, "dln(kf)_H2O": 1.26, "ln(ku)_H2O": -1.61, "dln(ku)_H2O": 0.92, "dGKIN_H2O": 13.36, "ddGKIN_H2O": -2.59, "mf": -2.92, "mu": 1.24, "PhiF_H2O": 0.12, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14941", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "K1006A,D1011G", "MUTATION_PDB": "K43A,D48G", "SEC_STR": "Beta,Coil", "RSA": "31.2,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.64, "dln(kf)_H2O": 1.12, "ln(ku)_H2O": -1.71, "dln(ku)_H2O": 0.82, "dGKIN_H2O": 13.26, "ddGKIN_H2O": -2.69, "mf": -2.8, "mu": 1.31, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14942", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "K1006A,D1011G", "MUTATION_PDB": "K43A,D48G", "SEC_STR": "Beta,Coil", "RSA": "31.2,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.64, "dln(kf)_H2O": 1.12, "ln(ku)_H2O": -1.71, "dln(ku)_H2O": 0.82, "dGKIN_H2O": 13.26, "ddGKIN_H2O": -2.69, "mf": -2.8, "mu": 1.31, "PhiF_H2O": 0.25, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14942", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1007A,D1011G", "MUTATION_PDB": "V44A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.1, "dln(kf)_H2O": -1.42, "ln(ku)_H2O": 0.12, "dln(ku)_H2O": 2.65, "dGKIN_H2O": 2.42, "ddGKIN_H2O": -13.53, "mf": -2.97, "mu": 1.24, "PhiF_H2O": 0.52, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14943", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1007A,D1011G", "MUTATION_PDB": "V44A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.1, "dln(kf)_H2O": -1.42, "ln(ku)_H2O": 0.12, "dln(ku)_H2O": 2.65, "dGKIN_H2O": 2.42, "ddGKIN_H2O": -13.53, "mf": -2.97, "mu": 1.24, "PhiF_H2O": 0.52, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14943", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1009A,D1011G", "MUTATION_PDB": "V46A,D48G", "SEC_STR": "Beta,Coil", "RSA": "12.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.17, "dln(kf)_H2O": -0.35, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": -0.13, "dGKIN_H2O": 11.98, "ddGKIN_H2O": -3.97, "mf": -3.0, "mu": 1.07, "PhiF_H2O": 1.1, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14944", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1009A,D1011G", "MUTATION_PDB": "V46A,D48G", "SEC_STR": "Beta,Coil", "RSA": "12.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.17, "dln(kf)_H2O": -0.35, "ln(ku)_H2O": -2.66, "dln(ku)_H2O": -0.13, "dGKIN_H2O": 11.98, "ddGKIN_H2O": -3.97, "mf": -3.0, "mu": 1.07, "PhiF_H2O": 1.1, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14944", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "N1010G", "MUTATION_PDB": "N47G", "SEC_STR": "Coil", "RSA": "93.6", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.89, "dln(kf)_H2O": 0.37, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": -0.69, "dGKIN_H2O": 15.14, "ddGKIN_H2O": 2.64, "mf": -3.15, "mu": 1.39, "PhiF_H2O": 0.69, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14945", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "N1010G", "MUTATION_PDB": "N47G", "SEC_STR": "Coil", "RSA": "93.6", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 2.89, "dln(kf)_H2O": 0.37, "ln(ku)_H2O": -3.22, "dln(ku)_H2O": -0.69, "dGKIN_H2O": 15.14, "ddGKIN_H2O": 2.64, "mf": -3.15, "mu": 1.39, "PhiF_H2O": 0.69, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14945", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "F1015A,D1011G", "MUTATION_PDB": "F52A,D48G", "SEC_STR": "Beta,Coil", "RSA": "28.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.16, "dln(kf)_H2O": -1.36, "ln(ku)_H2O": -0.97, "dln(ku)_H2O": 1.56, "dGKIN_H2O": 5.28, "ddGKIN_H2O": -10.67, "mf": -2.97, "mu": 1.14, "PhiF_H2O": 0.64, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14946", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "F1015A,D1011G", "MUTATION_PDB": "F52A,D48G", "SEC_STR": "Beta,Coil", "RSA": "28.4,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.16, "dln(kf)_H2O": -1.36, "ln(ku)_H2O": -0.97, "dln(ku)_H2O": 1.56, "dGKIN_H2O": 5.28, "ddGKIN_H2O": -10.67, "mf": -2.97, "mu": 1.14, "PhiF_H2O": 0.64, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14946", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1016A,D1011G", "MUTATION_PDB": "V53A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 0.96, "dln(kf)_H2O": -1.56, "ln(ku)_H2O": -0.73, "dln(ku)_H2O": 1.8, "dGKIN_H2O": 4.19, "ddGKIN_H2O": -11.76, "mf": -2.97, "mu": 1.26, "PhiF_H2O": 0.62, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14947", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1016A,D1011G", "MUTATION_PDB": "V53A,D48G", "SEC_STR": "Beta,Coil", "RSA": "0.0,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 0.96, "dln(kf)_H2O": -1.56, "ln(ku)_H2O": -0.73, "dln(ku)_H2O": 1.8, "dGKIN_H2O": 4.19, "ddGKIN_H2O": -11.76, "mf": -2.97, "mu": 1.26, "PhiF_H2O": 0.62, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14947", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A1018G,D1011G", "MUTATION_PDB": "A55G,D48G", "SEC_STR": "Helix,Coil", "RSA": "13.2,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.59, "dln(kf)_H2O": -0.93, "ln(ku)_H2O": -1.43, "dln(ku)_H2O": 1.1, "dGKIN_H2O": 7.47, "ddGKIN_H2O": -8.48, "mf": -2.6, "mu": 1.31, "PhiF_H2O": 0.68, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14948", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "A1018G,D1011G", "MUTATION_PDB": "A55G,D48G", "SEC_STR": "Helix,Coil", "RSA": "13.2,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.59, "dln(kf)_H2O": -0.93, "ln(ku)_H2O": -1.43, "dln(ku)_H2O": 1.1, "dGKIN_H2O": 7.47, "ddGKIN_H2O": -8.48, "mf": -2.6, "mu": 1.31, "PhiF_H2O": 0.68, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14948", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1021A,D1011G", "MUTATION_PDB": "V58A,D48G", "SEC_STR": "Beta,Coil", "RSA": "8.5,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.14, "dln(kf)_H2O": 0.62, "ln(ku)_H2O": 0.22, "dln(ku)_H2O": 2.75, "dGKIN_H2O": 7.24, "ddGKIN_H2O": -8.71, "mf": -3.07, "mu": 1.46, "PhiF_H2O": 0.22, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14949", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "V1021A,D1011G", "MUTATION_PDB": "V58A,D48G", "SEC_STR": "Beta,Coil", "RSA": "8.5,69.3", "T": 25.0, "pH": 3.5, "BUFFER_NAME": "Glycine", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 3.14, "dln(kf)_H2O": 0.62, "ln(ku)_H2O": 0.22, "dln(ku)_H2O": 2.75, "dGKIN_H2O": 7.24, "ddGKIN_H2O": -8.71, "mf": -3.07, "mu": 1.46, "PhiF_H2O": 0.22, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14949", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.31, "ln(ku)_H2O": -5.3, "dGKIN_H2O": 16.37, "mf": -2.18, "mu": 1.07, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14896", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "Spectrin SH3", "SOURCE": "Gallus gallus", "LENGTH": 62.0, "UniProt": "P07751", "PDB_wild": "1shg", "MUTATED_CHAIN": "A", "PFAM": [ "PF00018" ], "CATH": [ "1shgA00 (2.30.30.40)" ], "MUTATION_UNIPROT": "WT", "MUTATION_PDB": "WT", "T": 25.0, "pH": 7.0, "BUFFER_NAME": "Phosphate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": 1.31, "ln(ku)_H2O": -5.3, "dGKIN_H2O": 16.37, "mf": -2.18, "mu": 1.07, "AUTHOR_KIN": "Mart\u00ednez, J.C., Serrano, L.", "REFERENCE_KIN": "The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved. Nat. Struct. Biol. 6, 1010\u20131016. https://doi.org/10.1038/14896", "YEAR_KIN": 1999.0, "PMID_KIN": "10542091", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" } ]