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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14905", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "V52A", "MUTATION_PDB": "V52A", "SEC_STR": "Beta", "RSA": "1.4", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -2.71, "dln(kf)_H2O": -1.29, "ln(ku)_H2O": -7.64, "dln(ku)_H2O": 2.0, "ddGKIN_H2O": -8.25, "mf": -4.4, "mu": 1.25, "CM_KIN": 2.18, "PhiF_H2O": 0.39, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14906", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "P55A", "MUTATION_PDB": "P55A", "SEC_STR": "Beta", "RSA": "18.4", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -2.49, "dln(kf)_H2O": -1.07, "ln(ku)_H2O": -9.62, "dln(ku)_H2O": 0.02, "ddGKIN_H2O": -2.75, "mf": -4.25, "mu": 1.08, "CM_KIN": 3.35, "PhiF_H2O": 0.98, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. Biol. 6, 1005\u20131009. https://doi.org/10.1038/14907", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "P55A", "MUTATION_PDB": "P55A", "SEC_STR": "Beta", "RSA": "18.4", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -2.49, "dln(kf)_H2O": -1.07, "ln(ku)_H2O": -9.62, "dln(ku)_H2O": 0.02, "ddGKIN_H2O": -2.75, "mf": -4.25, "mu": 1.08, "CM_KIN": 3.35, "PhiF_H2O": 0.98, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14909", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "L66V", "MUTATION_PDB": "L66V", "SEC_STR": "Helix", "RSA": "0.6", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(ku)_H2O": -3.08, "dln(ku)_H2O": 6.56, "mu": 1.35, "PhiF_H2O": 0.27, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14911", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "I76V", "MUTATION_PDB": "I76V", "SEC_STR": "Beta", "RSA": "20.1", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.45, "dln(kf)_H2O": -0.03, "ln(ku)_H2O": -8.41, "dln(ku)_H2O": 1.23, "ddGKIN_H2O": -3.2, "mf": -4.2, "mu": 1.38, "CM_KIN": 3.12, "PhiF_H2O": 0.02, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14912", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "T79S", "MUTATION_PDB": "T79S", "SEC_STR": "Beta", "RSA": "14.8", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.47, "dln(kf)_H2O": -0.05, "ln(ku)_H2O": -7.45, "dln(ku)_H2O": 2.19, "ddGKIN_H2O": -5.6, "mf": -4.35, "mu": 1.1, "CM_KIN": 2.74, "PhiF_H2O": 0.02, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. Biol. 6, 1005\u20131009. https://doi.org/10.1038/14913", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "T79S", "MUTATION_PDB": "T79S", "SEC_STR": "Beta", "RSA": "14.8", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.47, "dln(kf)_H2O": -0.05, "ln(ku)_H2O": -7.45, "dln(ku)_H2O": 2.19, "ddGKIN_H2O": -5.6, "mf": -4.35, "mu": 1.1, "CM_KIN": 2.74, "PhiF_H2O": 0.02, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. Biol. 6, 1005\u20131009. https://doi.org/10.1038/14913", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "E84D", "MUTATION_PDB": "E84D", "SEC_STR": "Beta", "RSA": "44.3", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.52, "dln(kf)_H2O": -0.1, "ln(ku)_H2O": -7.35, "dln(ku)_H2O": 2.29, "ddGKIN_H2O": -6.0, "mf": -4.2, "mu": 1.15, "CM_KIN": 2.71, "PhiF_H2O": 0.04, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14914", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "I87V", "MUTATION_PDB": "I87V", "SEC_STR": "Beta", "RSA": "11.8", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.98, "dln(kf)_H2O": -0.56, "ln(ku)_H2O": -6.95, "dln(ku)_H2O": 2.69, "ddGKIN_H2O": -8.15, "mf": -3.68, "mu": 0.85, "CM_KIN": 2.75, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14915", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "L90A", "MUTATION_PDB": "L90A", "SEC_STR": "Coil", "RSA": "45.1", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(kf)_H2O": -1.67, "dln(kf)_H2O": -0.25, "ln(ku)_H2O": -6.44, "dln(ku)_H2O": 3.2, "ddGKIN_H2O": -8.65, "mf": -4.15, "mu": 1.03, "CM_KIN": 2.31, "PhiF_H2O": 0.07, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14916", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" }, { "PROTEIN": "mAcP", "SOURCE": "Homo sapiens", "LENGTH": 98.0, "UniProt": "P14621", "PDB_wild": "AF-P14621", "MUTATED_CHAIN": "A", "PFAM": [ "PF00708" ], "EC_NUMBER": "3.6.1.7", "MUTATION_UNIPROT": "F95L", "MUTATION_PDB": "F95L", "SEC_STR": "Beta", "RSA": "7.1", "T": 28.0, "pH": 5.5, "BUFFER_NAME": "Acetate", "BUFFER_CONC": "0.05", "MEASURE_KIN": "stopped-flow", "METHOD_KIN": "urea", "ln(ku)_H2O": -7.91, "dln(ku)_H2O": 1.73, "mu": -1.13, "PhiF_H2O": 0.76, "AUTHOR_KIN": "Chiti, F., Taddei, N., White, P.M., Bucciantini, M., Magherini, F., Stefani, M., Dobson, C.M.", "REFERENCE_KIN": "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat. Struct. 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Biol. 6, 1005\u20131009. https://doi.org/10.1038/14917", "YEAR_KIN": 1999.0, "PMID_KIN": "10542090", "STATE": "2", "REVERSIBILITY": "yes", "REVIEW_DATE": "2023-06-04T01:00:00" } ]