[
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "WT",
      "MUTATION_PDB": "WT",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
      "ln(kf)_H2O": 7.0,
      "ln(ku)_H2O": 1.06,
      "dGKIN_H2O": 13.97,
      "mf": -3.14,
      "mu": 1.13,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
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      "MUTATION_PDB": "WT",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
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      "MUTATION_PDB": "V4A",
      "SEC_STR": "Helix",
      "RSA": "28.2",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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         "PF16276"
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "BUFFER_CONC": "0.05",
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      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
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         "PF16276"
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "SEC_STR": "Helix",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "MUTATION_PDB": "A5G",
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      "BUFFER_NAME": "Sodium Phosphate",
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      "PhiF_H2O": 0.31,
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "SEC_STR": "Helix",
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      "BUFFER_NAME": "Sodium Phosphate",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
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         "PF16276"
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      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A246G",
      "MUTATION_PDB": "A6G",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
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      "mu": 1.26,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
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      "CATH": [
         "2vxdA00 (1.10.10.2100)"
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      "MUTATION_UNIPROT": "A246G",
      "MUTATION_PDB": "A6G",
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      "BUFFER_NAME": "Sodium Phosphate",
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      "MEASURE_KIN": "stopped-flow",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "I247V",
      "MUTATION_PDB": "I7V",
      "SEC_STR": "Helix",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
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         "PF16276"
      ],
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "SEC_STR": "Helix",
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      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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         "2vxdA00 (1.10.10.2100)"
      ],
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         "2vxdA00 (1.10.10.2100)"
      ],
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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         "2vxdA00 (1.10.10.2100)"
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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      "CATH": [
         "2vxdA00 (1.10.10.2100)"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "2vxdA00 (1.10.10.2100)"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
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      "UniProt": "P06748",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "SOURCE": "Homo sapiens",
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      "mf": -3.22,
      "mu": 1.0,
      "PhiF_H2O": 0.58,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "I269V",
      "MUTATION_PDB": "I29V",
      "SEC_STR": "Helix",
      "RSA": "20.7",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
      "ln(kf)_H2O": 6.55,
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      "ln(ku)_H2O": 1.03,
      "dln(ku)_H2O": -0.03,
      "dGKIN_H2O": 12.99,
      "ddGKIN_H2O": -0.96,
      "mf": -3.1,
      "mu": 1.09,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "I269V",
      "MUTATION_PDB": "I29V",
      "SEC_STR": "Helix",
      "RSA": "20.7",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "N270A",
      "MUTATION_PDB": "N30A",
      "SEC_STR": "Helix",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "N270A",
      "MUTATION_PDB": "N30A",
      "SEC_STR": "Helix",
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      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
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         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A270G",
      "MUTATION_PDB": "A30G",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "dGKIN_H2O": 11.59,
      "ddGKIN_H2O": -4.48,
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      "PhiF_H2O": 0.84,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A270G",
      "MUTATION_PDB": "A30G",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "PhiF_H2O": 0.84,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "V272A",
      "MUTATION_PDB": "V32A",
      "SEC_STR": "Helix",
      "RSA": "2.1",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "V272A",
      "MUTATION_PDB": "V32A",
      "SEC_STR": "Helix",
      "RSA": "2.1",
      "T": 10.0,
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      "BUFFER_NAME": "Sodium Phosphate",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
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      "SEC_STR": "Helix",
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      "BUFFER_CONC": "0.05",
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      "METHOD_KIN": "urea",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
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      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "K273A",
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      "SEC_STR": "Helix",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A273G",
      "MUTATION_PDB": "A33G",
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      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
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      "PhiF_H2O": 0.92,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
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         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A273G",
      "MUTATION_PDB": "A33G",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A283G",
      "MUTATION_PDB": "A43G",
      "SEC_STR": "Helix",
      "RSA": "15.1",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
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      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "A283G",
      "MUTATION_PDB": "A43G",
      "SEC_STR": "Helix",
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      "BUFFER_NAME": "Sodium Phosphate",
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      "PhiF_H2O": 0.56,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "PMID_KIN": "20212148",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
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      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
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      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
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      "SEC_STR": "Helix",
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      "SOURCE": "Homo sapiens",
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      ],
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         "2vxdA00 (1.10.10.2100)"
      ],
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         "2vxdA00 (1.10.10.2100)"
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         "2vxdA00 (1.10.10.2100)"
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         "2vxdA00 (1.10.10.2100)"
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      "SOURCE": "Homo sapiens",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
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         "2vxdA00 (1.10.10.2100)"
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "SOURCE": "Homo sapiens",
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      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
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      "SOURCE": "Homo sapiens",
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      "REVIEW_DATE": "2023-06-11T01:00:00"
   },
   {
      "PROTEIN": "Nucleophosmin, Cter-NPM1 domain",
      "SOURCE": "Homo sapiens",
      "LENGTH": 52.0,
      "UniProt": "P06748",
      "PDB_wild": "2vxd",
      "MUTATED_CHAIN": "A",
      "PFAM": [
         "PF16276"
      ],
      "CATH": [
         "2vxdA00 (1.10.10.2100)"
      ],
      "MUTATION_UNIPROT": "L294A",
      "MUTATION_PDB": "L54A",
      "SEC_STR": "Coil",
      "RSA": "59.8",
      "T": 10.0,
      "pH": 7.0,
      "BUFFER_NAME": "Sodium Phosphate",
      "BUFFER_CONC": "0.05",
      "ADDITIVES": "1 mM DTT",
      "MEASURE_KIN": "stopped-flow",
      "METHOD_KIN": "urea",
      "ln(kf)_H2O": 5.99,
      "dln(kf)_H2O": -1.01,
      "ln(ku)_H2O": 3.91,
      "dln(ku)_H2O": 2.85,
      "dGKIN_H2O": 4.89,
      "ddGKIN_H2O": -9.0,
      "mf": -2.09,
      "mu": 0.71,
      "PhiF_H2O": 0.26,
      "AUTHOR_KIN": "Scaloni F, Federici L, Brunori M, Gianni S",
      "REFERENCE_KIN": "Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A.107(12):5447-52. https://doi.org/10.1073/pnas.0910516107",
      "YEAR_KIN": 2010.0,
      "PMID_KIN": "20212148",
      "STATE": "Yes",
      "REVERSIBILITY": "yes",
      "REVIEW_DATE": "2023-06-11T01:00:00"
   }
]