Overview
KT-Pro is a collection of numerical data of thermodynamic parameters such as Gibbs free energy change,
enthalpy change, heat capacity change, transition temperature etc. for wild type and mutant proteins, that are important
for understanding the structure and stability of proteins. It also contains information about secondary structure and accessibility of wild type
residues, experimental conditions (pH, temperature, buffer, ion and protein concentration), measurements and methods used for each data,
and activity information (Km and Kcat ).
KT-Pro is cross-linked with protein sequence (UniProt)
and structure (PDB) database and literature databases
(PubMed).
The web interface enables users to search data based on various terms.
Reported Issues
The data collected in KT-Pro migth be affected by the following issues: Sign convention for free energy change,
uncorrect source organism, two kinds of temperatures in experimental data, lack of some experimental information and
duplication of data.
Disclaimer
KT-Pro database is a non-profit service to the scientific community. Curators have tried to provide accurate and up-to-date information.
However, ther is make no warranty that the information contained is accurate or complete. Manteiners have no responsibility for any damage
resulting from the use of this database.
References
KT-Pro database includes data from previously developed databases. Below are reported the references to manuscripts
presenting the databases
Nikam,R. et al. (2021) ProThermDB: thermodynamic database for proteins and mutants revisited after 15 years.
Nucleic Acids Res., 49, D420–D424.
PMID:33196841.
Stourac,J. et al. (2021) FireProtDB: database of manually curated protein stability data.
Nucleic Acids Res., 49, D319–D324.
PMID:33166383/.
Xavier,J.S. et al. (2021) ThermoMutDB: a thermodynamic database for missense mutations.
Nucleic Acids Res., 49, D475–D479.
PMID:33095862.
