I-Mutant2.0

I-Mutant2.0 Help
Last Update 27/12/06


 

 Data set used to train and test
the SVM exploiting structural information

PDB
Mutation
RSA(%)
Temperature
pH
Exp-DDG
Pred-Stability
Pred-DDG








1A23
H32L
31.56
30.00
7.00
4.60
Increase
3.44
1A23
H32L
31.56
30.00
7.00
5.30
Increase
3.44
1A23
H32S
31.56
30.00
7.00
3.60
Increase
2.94
1A23
H32S
31.56
30.00
7.00
5.20
Increase
2.94
1A23
H32Y
31.56
30.00
7.00
0.50
Increase
2.70
1A23
H32Y
31.56
30.00
7.00
6.80
Increase
2.70
1A23
H32Y
31.56
30.00
7.00
6.80
Increase
2.70
1AAR
K6E
49.00
25.00
5.00
0.53
Increase
1.01
1AAR
K6Q
49.00
25.00
5.00
0.26
Increase
-0.17
1AAR
F45W
18.49
25.00
5.00
0.32
Decrease
-1.39
1AAR
H68E
40.79
25.00
5.00
0.77
Decrease
0.55
1AAR
H68Q
40.79
25.00
5.00
0.55
Decrease
-0.78
1AAR
K27Q
7.83
25.00
5.00
-1.91
Decrease
-1.91
1AAR
K29N
32.43
25.00
5.00
-1.48
Decrease
-2.30
1AAR
K29Q
32.43
25.00
5.00
-1.67
Decrease
-1.12
1AAR
R42E
36.72
25.00
5.00
1.63
Decrease
-0.38
1AAR
R72Q
51.14
25.00
5.00
-0.33
Decrease
-1.05
1AG2
E200K
79.39
25.00
7.00
-0.14
Decrease
-0.23
1AG2
F198S
6.13
25.00
7.00
-2.46
Decrease
-2.55
1AG2
M129V
44.38
25.00
7.00
-0.33
Decrease
-0.52
1AG2
Q217R
22.96
25.00
7.00
-2.13
Decrease
-0.81
1AG2
R208H
43.23
25.00
7.00
-1.44
Decrease
-1.59
1AG2
T183A
2.45
25.00
7.00
-4.62
Decrease
-0.37
1AG2
T190V
52.56
25.00
7.00
-0.17
Increase
-0.94
1AG2
V180I
27.00
25.00
7.00
-0.50
Decrease
-1.08
1AG2
V210I
0.00
25.00
7.00
-0.26
Decrease
-0.81
1AJ3
W22F
32.89
25.00
7.50
-1.11
Decrease
-0.86
1AKK
L94V
2.46
83.00
2.00
-1.20
Decrease
-1.92
1ANK
D84H
8.26
51.80
7.20
-1.40
Decrease
-1.18
1ANK
F86L
1.54
51.80
7.20
-0.80
Decrease
-1.42
1ANK
G85V
9.53
51.80
7.20
-2.40
Increase
1.20
1ANK
R88G
29.34
51.80
7.40
-0.20
Decrease
-1.48
1ARR
P8L
32.63
20.00
7.50
2.40
Decrease
-3.34
1ARR
P8L
32.63
25.00
7.50
2.49
Decrease
-3.29
1ARR
P8L
32.63
53.40
7.50
2.55
Decrease
-2.90
1AYF
C95S
47.01
37.00
8.50
0.96
Decrease
-0.44
1AYF
D76E
60.24
37.00
8.50
0.45
Increase
0.42
1AYF
H56Q
3.08
37.00
8.50
-1.67
Decrease
-1.06
1AYF
H56R
3.08
37.00
8.50
-1.16
Decrease
-2.02
1AYF
H56T
3.08
37.00
8.50
-1.19
Decrease
-1.15
1AYF
T54A
41.24
37.00
8.50
-1.31
Decrease
-0.92
1AYF
T54S
41.24
37.00
8.50
0.05
Decrease
0.06
1AYF
Y82F
63.13
37.00
8.50
-0.01
Decrease
0.34
1AYF
Y82L
63.13
37.00
8.50
-0.36
Decrease
-0.74
1AYF
Y82S
63.13
37.00
8.50
-0.33
Decrease
-1.90
1AYF
Y82W
63.13
37.00
8.50
-0.21
Decrease
-0.91
1BNI
D8A
61.00
25.00
4.40
-0.69
Decrease
-0.81
1BNI
D8A
61.00
25.00
6.30
-0.90
Decrease
-0.86
1BNI
D8G
61.00
25.00
6.30
-1.17
Decrease
-1.25
1BNI
D8S
61.00
25.00
6.30
-0.97
Decrease
-0.70
1BNI
F7L
14.40
25.00
6.15
-4.60
Decrease
-2.17
1BNI
I4A
34.05
25.00
6.30
-1.40
Decrease
-2.45
1BNI
I4V
34.05
25.00
6.30
-0.60
Decrease
-0.02
1BNI
N5A
8.67
25.00
6.30
-1.90
Decrease
-2.67
1BNI
T6A
53.71
25.00
6.30
-2.10
Decrease
-0.81
1BNI
T6A
53.71
25.00
6.30
-2.23
Decrease
-0.81
1BNI
T6A
53.71
25.00
6.30
-2.53
Decrease
-0.81
1BNI
T6D
53.71
25.00
6.30
0.11
Decrease
-0.56
1BNI
T6E
53.71
25.00
6.30
-0.27
Decrease
-0.44
1BNI
T6G
53.71
25.00
6.30
-1.20
Decrease
-1.32
1BNI
T6G
53.71
25.00
6.30
-1.34
Decrease
-1.32
1BNI
T6H
53.71
25.00
4.40
-2.65
Decrease
-2.07
1BNI
T6H
53.71
25.00
8.90
-1.56
Decrease
-1.73
1BNI
T6N
53.71
25.00
6.30
-1.27
Decrease
-1.69
1BNI
T6P
53.71
25.00
6.30
-3.08
Decrease
-2.05
1BNI
T6Q
53.71
25.00
6.30
-1.87
Decrease
-1.54
1BNI
T6S
53.71
25.00
6.30
-0.22
Decrease
-1.70
1BNI
A32C
83.76
25.00
6.30
-1.00
Decrease
-0.40
1BNI
A32D
83.76
25.00
6.30
-0.70
Decrease
-0.16
1BNI
A32E
83.76
25.00
6.30
-0.60
Decrease
-0.18
1BNI
A32F
83.76
25.00
6.30
-0.70
Decrease
-0.73
1BNI
A32G
83.76
25.00
6.30
-0.90
Decrease
-0.94
1BNI
A32H
83.76
25.00
6.30
-0.80
Decrease
-0.44
1BNI
A32I
83.76
25.00
6.30
-0.80
Decrease
-0.46
1BNI
A32K
83.76
25.00
6.30
-0.20
Decrease
-1.23
1BNI
A32L
83.76
25.00
6.30
-0.30
Decrease
-1.05
1BNI
A32M
83.76
25.00
6.30
-0.30
Decrease
-1.01
1BNI
A32N
83.76
25.00
6.30
-0.70
Decrease
-0.15
1BNI
A32P
83.76
25.00
6.30
-4.10
Increase
0.28
1BNI
A32Q
83.76
25.00
6.30
-0.50
Decrease
-0.28
1BNI
A32R
83.76
25.00
6.30
-0.10
Decrease
-0.36
1BNI
A32S
83.76
25.00
6.30
-0.40
Decrease
-0.62
1BNI
A32T
83.76
25.00
6.30
-0.80
Decrease
-0.59
1BNI
A32V
83.76
25.00
6.30
-0.90
Decrease
0.07
1BNI
A32W
83.76
25.00
6.30
-1.00
Decrease
-0.23
1BNI
A32Y
83.76
25.00
6.30
-0.80
Decrease
-0.98
1BNI
D12A
54.20
25.00
6.30
0.43
Decrease
-0.68
1BNI
D12A
54.20
25.00
6.30
-0.30
Decrease
-0.68
1BNI
D12G
54.20
25.00
4.40
-0.78
Decrease
-0.77
1BNI
D12G
54.20
25.00
6.30
-1.29
Decrease
-0.81
1BNI
D12S
54.20
25.00
6.30
-0.65
Decrease
-0.78
1BNI
D22M
94.03
25.00
4.40
-0.27
Increase
-0.19
1BNI
D44E
77.72
25.00
6.30
0.10
Increase
-0.38
1BNI
D54A
19.71
25.00
6.30
-3.00
Decrease
-1.65
1BNI
D54A
19.71
25.00
6.30
-3.30
Decrease
-1.65
1BNI
D54N
19.71
25.00
4.40
-2.46
Decrease
-2.64
1BNI
D54N
19.71
25.00
4.40
-2.65
Decrease
-2.64
1BNI
D54N
19.71
25.00
4.40
-2.66
Decrease
-2.64
1BNI
D54N
19.71
25.00
6.30
-2.40
Decrease
-2.55
1BNI
D54N
19.71
25.00
6.30
-2.60
Decrease
-2.55
1BNI
D54N
19.71
25.00
8.90
-2.32
Decrease
-2.38
1BNI
D75N
0.35
25.00
6.30
-4.80
Decrease
-2.44
1BNI
D75N
0.35
25.00
6.30
-5.00
Decrease
-2.44
1BNI
D93N
47.81
25.00
6.30
-4.11
Decrease
-0.72
1BNI
E29A
48.20
25.00
6.30
-1.25
Decrease
-0.71
1BNI
E29G
48.20
25.00
6.30
-1.80
Decrease
-0.23
1BNI
E29G
48.20
25.00
6.30
-1.81
Decrease
-0.23
1BNI
E29Q
48.08
25.00
6.30
0.00
Decrease
-1.47
1BNI
E29S
48.20
25.00
6.30
-1.23
Decrease
-0.88
1BNI
E73A
6.70
25.00
6.30
-2.50
Decrease
-1.56
1BNI
G34A
48.92
25.00
6.30
-3.12
Increase
-1.14
1BNI
G34D
48.92
25.00
6.30
-3.39
Decrease
-2.11
1BNI
G34H
48.92
25.00
4.40
-2.60
Decrease
-2.29
1BNI
G34H
48.92
25.00
6.30
-2.65
Decrease
-2.24
1BNI
G34H
48.92
25.00
8.90
-3.15
Decrease
-2.14
1BNI
G34K
48.92
25.00
6.30
-3.12
Decrease
-2.44
1BNI
G34N
48.92
25.00
6.30
-2.75
Decrease
-2.41
1BNI
G34R
48.92
25.00
6.30
-2.42
Decrease
-1.97
1BNI
G34S
48.92
25.00
6.30
-3.20
Decrease
-2.10
1BNI
G34T
48.92
25.00
6.30
-3.37
Decrease
-2.89
1BNI
G52A
1.65
54.10
6.30
-5.30
Decrease
-4.63
1BNI
G52V
1.65
54.10
6.30
-8.40
Decrease
-4.12
1BNI
G53A
22.36
54.10
6.30
-3.40
Decrease
-2.97
1BNI
G53V
22.36
54.10
6.30
-7.80
Decrease
-2.59
1BNI
G65S
78.78
25.00
6.30
0.50
Decrease
-1.63
1BNI
H18A
56.40
25.00
6.30
-1.85
Decrease
-1.37
1BNI
H18D
56.40
25.00
6.30
-2.56
Decrease
-0.15
1BNI
H18G
56.40
25.00
5.80
-0.98
Decrease
-2.08
1BNI
H18G
56.40
25.00
6.30
-0.70
Decrease
-2.12
1BNI
H18G
56.40
25.00
9.00
0.51
Decrease
-2.30
1BNI
H18K
56.40
25.00
6.30
-1.19
Decrease
-2.12
1BNI
H18K
56.40
25.00
6.30
-1.20
Decrease
-2.12
1BNI
H18N
56.40
25.00
6.30
-1.68
Decrease
-1.39
1BNI
H18Q
56.40
25.00
6.30
-1.60
Decrease
-1.19
1BNI
H18R
56.40
25.00
6.30
-1.17
Decrease
-0.80
1BNI
H18S
56.40
25.00
6.30
-2.28
Decrease
-1.06
1BNI
I25A
10.76
25.00
6.30
-3.50
Decrease
-2.62
1BNI
I25V
10.76
25.00
6.30
-1.10
Decrease
-1.24
1BNI
I51A
0.11
25.00
6.30
-4.70
Decrease
-3.64
1BNI
I51V
0.11
25.00
4.40
-1.86
Decrease
-1.85
1BNI
I51V
0.11
25.00
6.30
-1.80
Decrease
-1.80
1BNI
I55A
51.89
25.00
6.30
-1.10
Decrease
-2.30
1BNI
I55T
51.89
25.00
6.30
-0.60
Decrease
-1.66
1BNI
I55V
51.89
25.00
6.30
-0.30
Decrease
0.41
1BNI
I55V
51.89
25.00
6.30
-0.30
Decrease
0.41
1BNI
I76A
0.00
25.00
6.30
-1.90
Decrease
-3.75
1BNI
I76V
0.00
25.00
6.30
-0.80
Decrease
-1.93
1BNI
I88A
0.00
25.00
6.30
-4.00
Decrease
-2.72
1BNI
I88A
0.00
25.00
6.30
-4.46
Decrease
-2.72
1BNI
I88A
0.00
25.00
6.30
-4.46
Decrease
-2.72
1BNI
I88A
0.00
48.00
6.30
-3.90
Decrease
-2.49
1BNI
I88L
0.00
25.00
6.30
-0.30
Decrease
-1.03
1BNI
I88V
0.00
25.00
4.40
-1.47
Decrease
-1.55
1BNI
I88V
0.00
25.00
6.30
-1.30
Decrease
-1.45
1BNI
I88V
0.00
25.00
6.30
-1.49
Decrease
-1.45
1BNI
I88V
0.00
25.00
6.30
-1.49
Decrease
-1.45
1BNI
I88V
0.00
48.00
6.30
-1.10
Decrease
-1.35
1BNI
I96A
0.00
25.00
6.30
-3.20
Decrease
-3.85
1BNI
I96A
0.00
25.00
6.30
-3.33
Decrease
-3.85
1BNI
I96A
0.00
25.00
6.30
-3.52
Decrease
-3.85
1BNI
I96A
0.00
25.00
6.30
-3.52
Decrease
-3.85
1BNI
I96A
0.00
25.00
6.30
-4.00
Decrease
-3.85
1BNI
I96A
0.00
48.00
6.30
-3.20
Decrease
-3.54
1BNI
I96V
0.00
25.00
4.40
-1.17
Decrease
-1.25
1BNI
I96V
0.00
25.00
4.40
-1.18
Decrease
-1.25
1BNI
I96V
0.00
25.00
6.30
-0.90
Decrease
-1.30
1BNI
I96V
0.00
25.00
6.30
-0.95
Decrease
-1.30
1BNI
I96V
0.00
25.00
6.30
-0.98
Decrease
-1.30
1BNI
I96V
0.00
25.00
6.30
-0.98
Decrease
-1.30
1BNI
I96V
0.00
25.00
6.30
-1.10
Decrease
-1.30
1BNI
I96V
0.00
48.00
6.30
-0.90
Decrease
-1.07
1BNI
K19R
35.00
25.00
6.30
0.20
Decrease
-1.85
1BNI
K27G
32.96
25.00
6.30
-0.40
Decrease
-1.59
1BNI
K27G
32.96
25.00
6.30
-0.55
Decrease
-1.59
1BNI
K62R
42.29
25.00
6.30
-0.50
Increase
1.08
1BNI
K62R
42.68
25.00
6.30
-0.40
Increase
1.08
1BNI
K66A
63.20
25.00
6.30
0.20
Increase
-0.93
1BNI
L14A
0.00
25.00
6.30
-4.30
Decrease
-3.97
1BNI
L14A
0.00
25.00
6.30
-4.80
Decrease
-3.97
1BNI
L14A
0.00
25.00
6.30
-4.80
Decrease
-3.97
1BNI
L14A
0.00
48.00
6.30
-4.20
Decrease
-3.57
1BNI
L33Q
52.10
25.00
6.30
-1.30
Decrease
-0.66
1BNI
L89T
0.00
25.00
6.30
-2.50
Decrease
-2.91
1BNI
L89V
0.00
25.00
6.30
-0.30
Decrease
-1.72
1BNI
L89V
0.00
25.00
6.30
-0.30
Decrease
-1.72
1BNI
N23A
9.29
25.00
6.30
-2.20
Decrease
-0.57
1BNI
N41D
18.92
25.00
6.30
-2.50
Increase
-0.55
1BNI
N58A
15.92
25.00
6.30
-2.70
Decrease
-1.27
1BNI
N58D
15.92
25.00
6.30
0.50
Decrease
-2.37
1BNI
N77A
48.70
25.00
6.30
-1.60
Decrease
-1.64
1BNI
N84A
34.70
25.00
6.30
-2.00
Decrease
-1.65
1BNI
Q15I
38.63
25.00
6.30
1.00
Decrease
0.40
1BNI
Q31A
56.77
25.00
6.30
0.10
Decrease
0.33
1BNI
Q31A
56.77
25.00
6.30
0.10
Decrease
0.33
1BNI
Q31G
56.77
25.00
6.30
-0.98
Decrease
-0.32
1BNI
Q31S
56.77
25.00
6.30
-0.20
Decrease
-0.71
1BNI
Q31S
56.77
25.00
6.30
-0.20
Decrease
-0.71
1BNI
Q31S
56.77
25.00
6.30
-0.25
Decrease
-0.71
1BNI
R69K
15.81
25.00
6.30
-3.13
Decrease
-3.29
1BNI
R69M
15.81
25.00
4.40
-2.86
Decrease
-1.52
1BNI
R69M
15.81
25.00
6.30
-2.12
Decrease
-1.52
1BNI
R69S
15.81
25.00
6.30
-2.72
Decrease
-1.47
1BNI
R83K
29.13
25.00
6.30
-4.13
Decrease
-1.68
1BNI
R83Q
29.13
25.00
4.40
-1.58
Decrease
-2.70
1BNI
R83Q
29.13
25.00
6.30
-2.05
Decrease
-2.62
1BNI
S28A
66.98
25.00
6.30
0.41
Increase
-0.46
1BNI
S28E
66.98
25.00
6.30
0.40
Increase
-0.08
1BNI
S28G
66.98
25.00
6.30
-0.45
Increase
-0.17
1BNI
S85A
23.89
25.00
6.30
-0.12
Decrease
-1.98
1BNI
S91A
0.94
25.00
4.40
-1.16
Decrease
-2.91
1BNI
S91A
0.94
25.00
4.40
-1.38
Decrease
-2.91
1BNI
S91A
0.94
25.00
6.30
-1.90
Decrease
-2.93
1BNI
S92A
47.27
25.00
4.40
-2.83
Decrease
-0.65
1BNI
S92A
47.27
25.00
6.30
-2.80
Decrease
-0.77
1BNI
T16A
75.20
25.00
6.30
-0.27
Decrease
-1.41
1BNI
T16G
75.20
25.00
6.30
-1.66
Decrease
-1.00
1BNI
T16R
75.20
25.00
4.40
0.20
Decrease
-0.70
1BNI
T16R
75.20
25.00
6.30
0.50
Decrease
-0.54
1BNI
T16R
75.20
25.00
6.30
0.50
Decrease
-0.54
1BNI
T16R
75.20
25.00
6.30
-0.48
Decrease
-0.54
1BNI
T16S
75.20
25.00
6.30
-1.70
Decrease
-0.17
1BNI
T16S
75.20
25.00
6.30
-1.87
Decrease
-0.17
1BNI
T26A
28.48
25.00
6.30
-1.90
Decrease
-2.02
1BNI
T26A
28.48
25.00
6.30
-2.11
Decrease
-2.02
1BNI
T26A
28.48
25.00
6.30
-2.14
Decrease
-2.02
1BNI
T26D
28.48
25.00
6.30
-0.08
Decrease
-1.62
1BNI
T26E
28.48
25.00
6.30
-0.05
Decrease
-0.57
1BNI
T26G
28.48
25.00
4.40
-2.08
Decrease
-1.55
1BNI
T26G
28.48
25.00
6.30
-1.50
Decrease
-1.47
1BNI
T26G
28.48
25.00
6.30
-1.58
Decrease
-1.47
1BNI
T26N
28.48
25.00
6.30
-1.29
Decrease
-1.50
1BNI
T26Q
28.48
25.00
6.30
-1.72
Decrease
-1.34
1BNI
T26S
28.48
25.00
6.30
-0.56
Decrease
-1.00
1BNI
T26V
28.48
25.00
6.30
-2.31
Decrease
-0.47
1BNI
T79V
78.59
25.00
6.30
0.30
Decrease
-0.82
1BNI
T99V
1.23
25.00
6.30
-2.70
Decrease
-1.67
1BNI
V10A
0.00
25.00
6.30
-3.40
Decrease
-3.14
1BNI
V10T
0.00
25.00
6.30
-2.50
Decrease
-3.34
1BNI
V36A
46.71
25.00
6.30
-1.30
Decrease
-0.77
1BNI
V36T
46.71
25.00
6.30
-1.10
Decrease
-1.96
1BNI
V45A
27.91
25.00
6.30
-1.80
Decrease
-0.54
1BNI
V45T
27.91
25.00
6.30
-2.40
Decrease
-0.98
1BNI
W94F
29.48
25.00
5.80
-1.06
Decrease
-1.31
1BNI
W94F
29.48
25.00
9.00
-0.60
Decrease
-1.20
1BNI
W94L
29.48
25.00
5.80
-1.59
Decrease
-1.50
1BNI
W94L
29.48
25.00
8.90
-0.64
Decrease
-1.45
1BNI
W94L
29.48
25.00
9.00
-0.66
Decrease
-1.45
1BNI
W94Y
29.48
25.00
5.80
-1.27
Decrease
-1.45
1BNI
W94Y
29.48
25.00
9.00
-0.99
Decrease
-1.35
1BNI
Y13A
18.30
25.00
6.30
-3.30
Decrease
-2.37
1BNI
Y13A
18.30
25.00
6.30
-3.71
Decrease
-2.37
1BNI
Y13F
18.30
25.00
6.30
-0.41
Decrease
-0.05
1BNI
Y17A
56.62
25.00
6.30
-2.00
Decrease
-1.30
1BNI
Y17A
56.62
25.00
6.30
-2.26
Decrease
-1.30
1BNI
Y17F
56.62
25.00
6.30
-0.30
Decrease
-0.94
1BNI
Y17G
56.62
25.00
6.30
-4.03
Decrease
-1.38
1BNI
Y17S
56.62
25.00
6.30
-2.57
Decrease
-1.16
1BNI
Y24F
8.10
25.00
6.30
0.00
Decrease
-2.29
1BNI
Y78F
4.40
25.00
6.30
-1.40
Decrease
0.17
1BNI
Y78F
4.40
25.00
6.30
-1.50
Decrease
0.17
1BNI
I109A
24.32
25.00
6.30
-2.10
Decrease
-2.17
1BNI
I109V
24.32
25.00
6.30
-0.80
Decrease
-0.39
1BNI
K108R
54.93
25.00
6.30
0.90
Decrease
-0.32
1BNI
Q104A
51.51
25.00
6.30
-0.20
Decrease
-0.70
1BNI
R110A
31.31
25.00
6.30
-0.40
Decrease
-1.47
1BNI
T105V
62.29
25.00
6.30
-2.20
Decrease
-0.20
1BNI
Y103F
28.22
25.00
6.30
0.00
Decrease
-1.14
1BPI
D3A
79.67
39.00
7.00
0.20
Decrease
-0.13
1BPI
E7A
26.79
39.00
7.00
-1.50
Decrease
-0.94
1BPI
F4A
10.91
39.00
7.00
-3.00
Decrease
-1.92
1BPI
L6A
60.84
39.00
7.00
-0.60
Decrease
-0.20
1BPI
P2A
47.78
39.00
7.00
-1.30
Decrease
-1.11
1BPI
P8A
76.53
39.00
7.00
-0.30
Decrease
-0.72
1BPI
P9A
34.60
39.00
7.00
-0.80
Decrease
-1.29
1BPI
R1A
63.01
39.00
7.00
-0.50
Decrease
-0.15
1BPI
D50A
36.02
39.00
7.00
-0.40
Decrease
-1.12
1BPI
E49A
65.83
39.00
7.00
-0.20
Decrease
-0.71
1BPI
F22A
11.56
25.00
2.00
-1.20
Decrease
-5.53
1BPI
F22A
11.56
39.00
7.00
-2.00
Decrease
-5.12
1BPI
F45A
10.11
25.00
2.00
-6.90
Decrease
-2.44
1BPI
G12A
21.73
39.00
7.00
-1.80
Decrease
-0.94
1BPI
G28A
53.62
39.00
7.00
-1.00
Decrease
-0.52
1BPI
G36A
0.25
39.00
7.00
-2.10
Decrease
-2.47
1BPI
G36S
0.76
72.60
4.60
-0.70
Decrease
-1.28
1BPI
G37A
43.71
39.00
7.00
-2.30
Decrease
-1.58
1BPI
G37A
43.84
25.00
2.00
-4.90
Decrease
-1.68
1BPI
G56A
23.89
39.00
7.00
-0.20
Decrease
-0.89
1BPI
G57A
54.51
39.00
7.00
-0.20
Decrease
-1.28
1BPI
I18A
36.97
39.00
7.00
-1.50
Decrease
-1.28
1BPI
I19A
58.05
39.00
7.00
-2.10
Decrease
-0.28
1BPI
K15A
90.52
39.00
7.00
-0.40
Increase
0.26
1BPI
K26A
102.24
39.00
7.00
0.00
Increase
-0.94
1BPI
K41A
47.59
39.00
7.00
-0.40
Decrease
-0.76
1BPI
K46A
80.36
39.00
7.00
0.10
Decrease
0.26
1BPI
L29A
60.57
39.00
7.00
0.00
Decrease
-1.22
1BPI
M52A
62.72
39.00
7.00
-1.70
Decrease
-0.67
1BPI
N24A
23.84
39.00
7.00
-2.20
Decrease
-2.35
1BPI
N43G
0.68
25.00
2.00
-5.70
Decrease
-4.35
1BPI
N43G
0.75
25.00
2.00
-5.70
Decrease
-4.35
1BPI
N44A
14.69
39.00
7.00
-3.30
Decrease
-2.71
1BPI
N44G
14.00
25.00
2.00
-4.70
Decrease
-4.44
1BPI
P13A
52.36
39.00
7.00
-1.20
Decrease
-2.70
1BPI
Q31A
36.39
39.00
7.00
-1.00
Decrease
-0.29
1BPI
R17A
89.17
39.00
7.00
-0.30
Decrease
-0.24
1BPI
R20A
15.46
39.00
7.00
-1.80
Decrease
-1.63
1BPI
R39A
80.13
39.00
7.00
0.00
Decrease
-0.14
1BPI
R42A
70.44
39.00
7.00
-0.50
Decrease
-0.46
1BPI
R53A
74.41
39.00
7.00
-0.10
Decrease
-0.06
1BPI
S47A
30.46
39.00
7.00
-1.60
Decrease
0.17
1BPI
T11A
47.44
39.00
7.00
0.00
Decrease
-0.46
1BPI
T32A
56.96
39.00
7.00
-0.10
Decrease
-0.76
1BPI
T54A
36.12
39.00
7.00
-0.10
Decrease
-0.92
1BPI
V34A
40.27
39.00
7.00
-1.20
Decrease
-1.54
1BPI
Y10A
36.59
39.00
7.00
-1.20
Decrease
-1.90
1BPI
Y23A
4.21
25.00
2.00
-5.90
Decrease
-2.66
1BPI
Y35A
6.69
39.00
7.00
-1.10
Decrease
-3.67
1BPI
Y35G
5.80
25.00
2.00
-5.00
Decrease
-3.30
1BPI
Y35G
6.69
25.00
2.00
-5.00
Decrease
-3.27
1BTA
C82A
27.92
25.00
7.40
0.48
Decrease
1.14
1BVC
E4A
70.06
25.00
4.00
-0.55
Decrease
-0.11
1BVC
E4A
70.06
25.00
4.00
-0.70
Decrease
-0.11
1BVC
L9A
30.58
82.20
9.60
-0.40
Decrease
-0.68
1BVC
Q8A
45.86
4.00
4.20
0.89
Decrease
-0.01
1BVC
Q8A
45.86
4.00
4.20
1.07
Decrease
-0.01
1BVC
Q8G
45.86
4.00
4.20
-0.50
Decrease
-0.72
1BVC
Q8G
45.86
4.00
4.20
-0.63
Decrease
-0.72
1BVC
W7F
7.28
4.00
7.80
0.10
Decrease
-0.94
1BVC
W7F
7.28
4.00
7.80
-0.90
Decrease
-0.94
1BVC
W7F
7.28
4.00
7.80
-1.10
Decrease
-0.94
1BVC
D44A
73.42
25.00
4.00
-0.15
Decrease
-0.70
1BVC
D44A
73.42
25.00
4.00
-0.20
Decrease
-0.70
1BVC
D60A
38.24
25.00
4.00
-0.10
Decrease
-1.16
1BVC
D60A
38.24
25.00
4.00
-0.15
Decrease
-1.16
1BVC
E18A
44.88
25.00
4.00
-0.50
Decrease
-0.32
1BVC
E18A
44.88
25.00
4.00
-0.70
Decrease
-0.32
1BVC
G23A
20.33
82.20
9.60
-1.10
Decrease
0.41
1BVC
H36Q
23.97
4.00
7.80
-0.10
Increase
-0.29
1BVC
H36Q
23.97
4.00
7.80
-0.70
Increase
-0.29
1BVC
H36Q
23.97
4.00
7.80
-0.80
Increase
-0.29
1BVC
I28A
0.97
76.50
11.00
-1.30
Decrease
-1.63
1BVC
I28L
0.97
76.50
11.00
-0.60
Decrease
-0.35
1BVC
I28M
0.97
76.50
11.00
-0.60
Decrease
-0.50
1BVC
I28V
0.97
76.50
11.00
0.00
Decrease
0.03
1BVC
K56A
58.63
25.00
4.00
-0.20
Decrease
-0.04
1BVC
K56A
58.63
25.00
4.00
-0.25
Decrease
-0.04
1BVC
K77A
49.00
25.00
4.00
-0.02
Increase
0.79
1BVC
K77A
49.00
25.00
4.00
-0.05
Increase
0.79
1BVC
L11A
24.03
82.20
9.60
-0.40
Decrease
-0.96
1BVC
L29A
2.62
76.50
11.00
-2.40
Decrease
-1.99
1BVC
L29I
2.62
76.50
11.00
-1.10
Decrease
-1.06
1BVC
L29M
2.62
76.50
11.00
0.10
Decrease
-1.19
1BVC
L29V
2.62
76.50
11.00
-1.70
Decrease
-0.29
1BVC
L49I
3.28
76.50
11.00
-0.80
Decrease
-0.70
1BVC
L69A
0.60
76.50
11.00
-1.20
Decrease
-1.86
1BVC
L69I
0.60
76.50
11.00
0.00
Decrease
0.03
1BVC
L69M
0.60
76.50
11.00
0.00
Decrease
0.10
1BVC
L69V
0.60
76.50
11.00
-0.10
Decrease
-1.08
1BVC
P88A
52.85
82.20
9.60
0.60
Decrease
-0.98
1BVC
T51A
46.14
82.20
9.60
-1.40
Decrease
-0.06
1BVC
T67A
66.33
82.20
9.60
-0.30
Decrease
0.28
1BVC
V13A
0.00
82.20
9.60
-0.70
Decrease
-0.10
1BVC
V66A
37.09
82.20
9.60
0.80
Decrease
-1.31
1BVC
V68T
20.30
4.00
7.80
-0.20
Decrease
-2.71
1BVC
V68T
20.30
4.00
7.80
-0.40
Decrease
-2.71
1BVC
V68T
20.30
4.00
7.80
-0.60
Decrease
-2.71
1BVC
W14F
1.08
4.00
7.80
-0.50
Decrease
-1.29
1BVC
W14F
1.08
4.00
7.80
-0.60
Decrease
-1.29
1BVC
W14F
1.08
4.00
7.80
-1.10
Decrease
-1.29
1BVC
A130K
0.00
4.00
7.80
-0.90
Decrease
-3.02
1BVC
A130K
0.00
4.00
7.80
-1.20
Decrease
-3.02
1BVC
A130K
0.00
4.00
7.80
-2.10
Decrease
-3.02
1BVC
A130L
0.00
4.00
7.80
0.10
Decrease
0.81
1BVC
A130L
0.00
4.00
7.80
-0.90
Decrease
0.81
1BVC
A130L
0.00
4.00
7.80
-1.00
Decrease
0.81
1BVC
E109A
56.84
4.00
4.20
0.17
Decrease
-0.84
1BVC
E109A
56.84
4.00
4.20
0.36
Decrease
-0.84
1BVC
E109G
56.84
4.00
4.20
-0.89
Decrease
-0.76
1BVC
E109G
56.84
4.00
4.20
-0.96
Decrease
-0.76
1BVC
F123K
0.50
4.00
7.80
-0.70
Decrease
-3.01
1BVC
F123K
0.50
4.00
7.80
-1.40
Decrease
-3.01
1BVC
F123K
0.50
4.00
7.80
-2.10
Decrease
-3.01
1BVC
G129A
36.85
82.20
9.60
1.10
Decrease
-0.38
1BVC
H116A
49.48
82.20
9.60
0.20
Increase
0.88
1BVC
I111A
2.70
76.50
11.00
-1.80
Decrease
-2.41
1BVC
I111L
2.70
76.50
11.00
-0.60
Decrease
-0.66
1BVC
I111M
2.70
76.50
11.00
-1.10
Decrease
-1.02
1BVC
I142A
0.00
82.20
9.60
-1.90
Decrease
-1.29
1BVC
I142A
0.16
76.50
11.00
-1.10
Decrease
-1.34
1BVC
I142L
0.16
76.50
11.00
0.60
Decrease
0.26
1BVC
I142M
0.16
76.50
11.00
0.90
Decrease
-0.55
1BVC
I142V
0.16
76.50
11.00
-0.10
Decrease
-0.13
1BVC
K140A
63.98
4.00
4.20
0.35
Decrease
-0.46
1BVC
K140A
63.98
4.00
4.20
0.60
Decrease
-0.46
1BVC
L135I
1.04
76.50
11.00
-1.50
Decrease
-1.51
1BVC
L135M
1.04
76.50
11.00
-0.80
Decrease
-0.51
1BVC
L135V
1.04
76.50
11.00
-2.20
Decrease
-1.66
1BVC
L137A
12.02
82.20
9.60
-1.80
Decrease
-1.12
1BVC
L149A
32.22
82.20
9.60
-1.60
Decrease
-0.67
1BVC
M131A
0.00
4.00
7.80
-0.90
Decrease
-2.36
1BVC
M131A
0.00
4.00
7.80
-1.30
Decrease
-2.36
1BVC
M131A
0.00
4.00
7.80
-2.20
Decrease
-2.36
1BVC
S117A
63.99
82.20
9.60
-0.30
Decrease
-0.87
1BVC
V114A
6.51
82.20
9.60
-1.40
Decrease
-1.63
1C2R
G34S
15.76
30.00
7.50
-2.20
Decrease
-2.25
1C2R
K12D
39.38
25.00
7.50
-1.30
Increase
-0.30
1C2R
K14E
47.16
25.00
7.50
-1.30
Decrease
-0.04
1C2R
K32E
69.03
25.00
7.50
0.20
Increase
-1.06
1C2R
P35A
17.05
30.00
7.50
-2.00
Decrease
-1.31
1C9O
Q2L
38.69
70.00
7.00
0.29
Increase
0.38
1C9O
Q2L
38.69
70.00
7.00
0.29
Increase
0.38
1C9O
Q2L
38.69
70.00
7.00
0.55
Increase
0.38
1C9O
Q2L
38.69
70.00
7.00
0.55
Increase
0.38
1C9O
R3A
67.29
70.00
7.00
-1.05
Decrease
-0.45
1C9O
R3A
67.29
70.00
7.00
-1.89
Decrease
-0.45
1C9O
R3E
67.29
70.00
7.00
-1.00
Decrease
-0.37
1C9O
R3E
67.29
70.00
7.00
-1.00
Decrease
-0.37
1C9O
R3E
67.29
70.00
7.00
-2.75
Decrease
-0.37
1C9O
R3E
67.29
70.00
7.00
-2.75
Decrease
-0.37
1C9O
R3K
67.29
70.00
7.00
-0.14
Decrease
-0.63
1C9O
R3K
67.29
70.00
7.00
-0.19
Decrease
-0.63
1C9O
R3L
67.29
70.00
7.00
-0.22
Decrease
-0.20
1C9O
R3L
67.29
70.00
7.00
-0.93
Decrease
-0.20
1C9O
E46A
32.05
70.00
7.00
-0.12
Decrease
-0.76
1C9O
E46A
32.05
70.00
7.00
-0.12
Decrease
-0.76
1C9O
E46A
32.05
70.00
7.00
-0.22
Decrease
-0.76
1C9O
E46A
32.05
70.00
7.00
-0.22
Decrease
-0.76
1C9O
G23Q
58.58
70.00
7.00
-0.29
Decrease
-0.67
1C9O
G23Q
58.58
70.00
7.00
-0.29
Decrease
-0.67
1C9O
G23Q
58.58
70.00
7.00
-0.31
Decrease
-0.67
1C9O
G23Q
58.58
70.00
7.00
-0.31
Decrease
-0.67
1C9O
L66E
61.22
70.00
7.00
-1.24
Decrease
-0.78
1C9O
L66E
61.22
70.00
7.00
-1.24
Decrease
-0.78
1C9O
L66E
61.22
70.00
7.00
-1.27
Decrease
-0.78
1C9O
L66E
61.22
70.00
7.00
-1.27
Decrease
-0.78
1C9O
N11S
50.89
70.00
7.00
0.22
Increase
0.65
1C9O
N11S
50.89
70.00
7.00
0.22
Increase
0.65
1C9O
N11S
50.89
70.00
7.00
0.33
Increase
0.65
1C9O
N11S
50.89
70.00
7.00
0.33
Increase
0.65
1C9O
Q53E
58.85
70.00
7.00
0.00
Increase
-0.15
1C9O
Q53E
58.85
70.00
7.00
0.00
Increase
-0.15
1C9O
Q53E
58.85
70.00
7.00
-0.10
Increase
-0.15
1C9O
Q53E
58.85
70.00
7.00
-0.10
Increase
-0.15
1C9O
S24D
82.85
70.00
7.00
0.19
Increase
0.64
1C9O
S24D
82.85
70.00
7.00
0.19
Increase
0.64
1C9O
S24D
82.85
70.00
7.00
0.22
Increase
0.64
1C9O
S24D
82.85
70.00
7.00
0.22
Increase
0.64
1C9O
T31S
22.13
70.00
7.00
0.17
Decrease
0.05
1C9O
T31S
22.13
70.00
7.00
0.17
Decrease
0.05
1C9O
T31S
22.13
70.00
7.00
0.19
Decrease
0.05
1C9O
T31S
22.13
70.00
7.00
0.19
Decrease
0.05
1C9O
V64T
40.34
70.00
7.00
-0.19
Decrease
-1.29
1C9O
V64T
40.34
70.00
7.00
-0.19
Decrease
-1.29
1C9O
V64T
40.34
70.00
7.00
-0.26
Decrease
-1.29
1C9O
V64T
40.34
70.00
7.00
-0.26
Decrease
-1.29
1C9O
Y15F
31.07
70.00
7.00
0.07
Increase
0.92
1C9O
Y15F
31.07
70.00
7.00
0.07
Increase
0.92
1C9O
Y15F
31.07
70.00
7.00
-0.05
Increase
0.92
1C9O
Y15F
31.07
70.00
7.00
-0.05
Increase
0.92
1CAH
W5F
26.86
23.00
7.50
0.10
Decrease
0.05
1CAH
W5F
26.86
23.00
7.50
-2.50
Decrease
0.05
1CAH
W16F
1.58
23.00
7.50
0.30
Decrease
-0.62
1CAH
W16F
1.58
23.00
7.50
-6.30
Decrease
-0.62
1CAH
C206S
6.41
23.00
7.50
0.10
Decrease
-2.84
1CAH
C206S
6.41
23.00
7.50
-0.70
Decrease
-2.84
1CHK
W28F
10.48
42.70
7.00
-3.56
Decrease
-2.34
1CHK
W28F
10.48
43.20
7.00
-4.43
Decrease
-2.33
1CHK
W28F
10.48
52.20
7.00
-1.76
Decrease
-2.25
1CHK
W101F
0.00
42.70
7.00
-3.91
Decrease
-1.20
1CHK
W101F
0.00
43.20
7.00
-4.27
Decrease
-1.20
1CHK
W101F
0.00
52.20
7.00
-1.89
Decrease
-1.15
1CHK
W227F
3.62
42.70
7.00
-2.97
Decrease
-1.55
1CHK
W227F
3.62
43.20
7.00
-2.51
Decrease
-1.55
1CHK
W227F
3.62
52.20
7.00
-1.31
Decrease
-1.54
1CSP
E3L
44.88
70.00
7.00
0.41
Increase
1.41
1CSP
E3L
44.88
70.00
7.00
1.60
Increase
1.41
1CSP
E3R
44.88
70.00
7.00
0.77
Increase
-0.11
1CSP
E3R
44.88
70.00
7.00
0.77
Increase
-0.11
1CSP
E3R
44.88
70.00
7.00
2.66
Increase
-0.11
1CSP
E3R
44.88
70.00
7.00
2.66
Increase
-0.11
1CSP
E66L
26.79
70.00
7.00
1.44
Increase
1.91
1CSP
E66L
26.79
70.00
7.00
1.44
Increase
1.91
1CSP
E66L
26.79
70.00
7.00
2.11
Increase
1.91
1CSP
E66L
26.79
70.00
7.00
2.11
Increase
1.91
1CSP
F15A
27.40
60.00
7.00
-1.67
Decrease
-0.52
1CSP
F17A
29.55
60.00
7.00
-1.34
Decrease
-0.46
1CSP
F27A
35.72
60.00
7.00
-0.69
Decrease
-1.36
1CSP
F38A
80.52
60.00
7.00
0.31
Decrease
-0.94
1CYO
F35H
9.92
66.20
7.00
-2.82
Decrease
-1.98
1CYO
F35L
9.92
66.20
7.00
-1.87
Increase
-0.64
1CYO
F35Y
9.92
66.20
7.00
0.79
Decrease
-0.31
1CYO
V45E
50.81
66.70
7.00
-2.68
Decrease
-1.11
1CYO
V45E
50.81
77.60
7.00
-2.06
Decrease
-1.14
1CYO
V45G
50.81
25.00
7.00
-1.91
Decrease
-3.07
1CYO
V45H
50.81
25.00
7.00
-1.65
Decrease
-2.27
1CYO
V45H
50.81
66.70
7.00
-1.34
Decrease
-2.46
1CYO
V45H
50.81
77.60
7.00
-1.39
Decrease
-2.48
1CYO
V45T
50.81
25.00
7.00
-0.96
Decrease
-0.93
1CYO
V45Y
50.81
66.70
7.00
-1.53
Decrease
-0.54
1CYO
V45Y
50.81
77.60
7.00
-1.56
Decrease
-0.56
1CYO
V61E
72.93
25.00
7.00
-1.05
Decrease
-1.48
1CYO
V61E
72.93
67.20
7.00
-1.10
Decrease
-1.51
1CYO
V61H
72.93
25.00
7.00
-1.60
Decrease
-0.61
1CYO
V61H
72.93
67.20
7.00
-1.63
Decrease
-0.29
1CYO
V61K
72.93
25.00
7.00
-2.39
Decrease
-0.68
1CYO
V61K
72.93
67.20
7.00
-2.34
Decrease
-0.64
1CYO
V61Y
72.93
25.00
7.00
-1.34
Decrease
-1.30
1CYO
V61Y
72.93
67.20
7.00
-1.29
Decrease
-1.25
1EL1
A93S
57.26
66.40
4.50
-0.26
Decrease
0.44
1EL1
H21G
57.50
66.40
4.50
-0.48
Increase
0.16
1EL1
I56L
0.05
66.40
4.50
-0.24
Decrease
-0.51
1EL1
V109K
7.09
66.40
4.50
-0.43
Decrease
-1.04
1EM7
I6N
24.00
25.00
5.20
2.07
Decrease
0.56
1EM7
I6N
24.00
63.00
5.20
1.82
Increase
0.24
1EM7
I6T
24.00
25.00
5.20
2.00
Increase
-0.16
1EM7
I6T
24.00
63.00
5.20
1.76
Increase
-0.11
1EM7
T53F
32.59
25.00
5.20
4.61
Increase
2.11
1EM7
T53F
32.59
63.00
5.20
4.10
Increase
1.93
1EM7
T53I
32.59
25.00
5.20
3.30
Increase
2.02
1EM7
T53I
32.59
63.00
5.20
3.81
Increase
2.12
1EM7
T53V
32.59
25.00
5.20
2.80
Increase
1.42
1EM7
T53V
32.59
63.00
5.20
3.38
Increase
1.56
1EM7
T53Y
32.59
25.00
5.20
4.10
Increase
2.31
1EM7
T53Y
32.59
63.00
5.20
4.29
Increase
2.34
1G6N
S128A
10.07
20.00
7.90
-0.26
Decrease
0.00
1G6N
S128P
10.07
20.00
7.90
0.14
Increase
-2.80
1HFY
A30I
0.00
20.00
2.00
0.30
Increase
1.84
1HFY
A30T
0.00
20.00
2.00
0.06
Decrease
-0.72
1HFY
T29I
0.00
20.00
2.00
0.12
Increase
0.15
1HFY
T33I
13.27
20.00
2.00
0.18
Decrease
-0.31
1HUE
A27S
0.00
63.90
7.00
-1.19
Decrease
-1.23
1HUE
A56S
72.60
63.90
7.00
-0.13
Decrease
1.07
1HUE
M69I
30.58
63.90
7.00
0.00
Increase
0.62
1HUE
S31T
20.65
63.90
7.00
0.41
Increase
0.45
1HUE
V42I
0.20
63.90
7.00
-0.82
Decrease
-0.74
1IGV
D19N
47.54
25.00
7.00
0.74
Increase
0.70
1IGV
E17Q
63.77
25.00
7.00
0.38
Decrease
0.16
1IGV
E26Q
73.55
25.00
7.00
0.09
Decrease
0.34
1IOB
T9A
3.89
25.00
6.50
-0.80
Decrease
-1.06
1IOB
T9G
3.89
25.00
6.50
-2.60
Decrease
-2.55
1IOB
T9L
3.89
25.00
6.50
-0.70
Decrease
-0.65
1IOB
T9Q
3.89
25.00
6.50
-1.90
Decrease
-1.00
1IOB
K97G
44.48
25.00
6.50
-1.20
Decrease
-0.53
1IOB
K97R
44.48
25.00
6.50
-0.50
Decrease
-0.78
1IOB
K97V
44.48
25.00
6.50
0.80
Increase
0.18
1LZ1
A9S
0.00
64.90
2.70
-0.02
Decrease
-1.63
1LZ1
E7Q
30.97
65.00
2.20
0.10
Decrease
-0.48
1LZ1
E7Q
30.97
65.00
2.30
-0.43
Decrease
-0.48
1LZ1
E7Q
30.97
65.00
4.00
-1.44
Decrease
-0.44
1LZ1
E7Q
30.97
65.00
4.50
-1.29
Decrease
-0.43
1LZ1
K1A
34.61
64.90
2.70
-0.60
Decrease
0.22
1LZ1
K1M
34.61
64.90
2.70
-0.12
Increase
0.09
1LZ1
L8T
0.00
64.90
2.70
-3.73
Decrease
-2.58
1LZ1
V2A
69.29
49.20
2.70
-1.51
Decrease
-0.68
1LZ1
V2A
69.42
64.90
2.70
-1.51
Decrease
-0.52
1LZ1
V2D
65.97
64.90
2.70
-1.44
Decrease
-0.53
1LZ1
V2F
69.42
64.90
2.70
-0.86
Decrease
-1.22
1LZ1
V2G
69.42
64.90
2.70
-2.30
Decrease
-0.90
1LZ1
V2I
69.42
64.90
2.70
1.10
Decrease
-0.53
1LZ1
V2L
69.42
64.90
2.70
-0.05
Increase
-0.55
1LZ1
V2M
69.42
64.90
2.70
-0.31
Decrease
-0.40
1LZ1
V2N
65.97
64.90
2.70
-1.34
Decrease
-1.40
1LZ1
V2R
65.97
64.90
2.70
-0.38
Decrease
-0.58
1LZ1
V2S
65.97
64.90
2.70
-1.41
Decrease
-0.54
1LZ1
V2Y
65.97
64.90
2.70
-0.36
Decrease
-0.98
1LZ1
A32L
0.00
64.90
2.70
-0.10
Increase
1.52
1LZ1
A32S
0.00
64.90
2.70
-0.33
Decrease
0.17
1LZ1
A47P
76.50
68.80
2.80
0.10
Increase
0.99
1LZ1
A92S
2.72
64.90
2.70
0.81
Decrease
-1.29
1LZ1
A96M
0.00
64.90
2.70
0.02
Decrease
-0.53
1LZ1
A96S
0.00
64.90
2.70
-1.00
Decrease
-0.88
1LZ1
C77A
14.67
57.00
3.00
-4.60
Decrease
-0.78
1LZ1
D18N
46.56
65.00
2.20
-0.53
Decrease
-0.55
1LZ1
D18N
46.56
65.00
4.00
-1.70
Decrease
-0.63
1LZ1
D49N
50.52
65.00
2.20
0.00
Increase
-0.28
1LZ1
D49N
50.52
65.00
4.00
-1.00
Increase
-0.24
1LZ1
D67N
24.01
65.00
2.20
-0.24
Decrease
-3.28
1LZ1
D67N
24.01
65.00
2.30
-0.26
Decrease
-3.28
1LZ1
D67N
24.01
65.00
4.00
-2.25
Decrease
-3.24
1LZ1
D67N
24.01
65.00
4.50
-1.70
Decrease
-3.22
1LZ1
D91P
34.35
68.80
2.80
-0.40
Decrease
-1.10
1LZ1
E35L
20.03
64.90
2.70
-0.53
Increase
0.71
1LZ1
G37A
49.68
64.90
2.70
-0.29
Decrease
-0.10
1LZ1
G37Q
49.68
64.90
2.70
-0.26
Decrease
-0.12
1LZ1
G37Q
49.68
64.90
2.70
-0.26
Decrease
-0.12
1LZ1
H78A
83.62
64.90
2.70
-0.14
Decrease
-0.18
1LZ1
H78G
83.62
64.90
2.70
-0.12
Decrease
-0.08
1LZ1
H78G
83.62
64.90
2.70
-0.12
Decrease
-0.08
1LZ1
I23A
8.27
64.90
2.70
-2.54
Decrease
-1.12
1LZ1
I23V
6.65
49.20
2.70
-0.41
Decrease
-1.12
1LZ1
I23V
8.27
64.90
2.70
-0.36
Decrease
-0.88
1LZ1
I56A
0.38
64.90
2.70
-3.71
Decrease
-4.22
1LZ1
I56A
0.38
64.90
2.70
-3.71
Decrease
-4.22
1LZ1
I56F
0.38
64.90
2.70
-4.09
Decrease
-1.58
1LZ1
I56L
0.38
64.90
2.70
-0.10
Decrease
-0.01
1LZ1
I56M
0.38
64.90
2.70
-1.77
Decrease
-1.42
1LZ1
I56T
0.38
64.90
2.70
-3.64
Decrease
-4.89
1LZ1
I56T
0.38
64.90
2.70
-3.64
Decrease
-4.89
1LZ1
I56V
0.38
49.20
2.70
-1.34
Decrease
-1.26
1LZ1
I56V
0.38
64.90
2.70
-1.20
Decrease
-1.17
1LZ1
I56V
0.38
64.90
2.70
-1.20
Decrease
-1.17
1LZ1
I59A
1.62
49.20
2.70
-1.32
Decrease
-3.20
1LZ1
I59A
1.62
64.90
2.70
-1.72
Decrease
-3.10
1LZ1
I59A
1.62
64.90
2.70
-1.72
Decrease
-3.10
1LZ1
I59F
1.62
64.90
2.70
-0.81
Decrease
-1.62
1LZ1
I59G
1.62
64.90
2.70
-3.83
Decrease
-2.71
1LZ1
I59G
1.62
64.90
2.70
-3.83
Decrease
-2.71
1LZ1
I59L
1.62
64.90
2.70
0.00
Decrease
-0.17
1LZ1
I59M
1.62
64.90
2.70
-1.29
Decrease
-1.34
1LZ1
I59S
1.62
64.90
2.70
-3.59
Decrease
-2.26
1LZ1
I59T
1.62
64.90
2.70
-2.22
Decrease
-3.37
1LZ1
I59V
1.46
49.20
2.70
-0.93
Decrease
-0.71
1LZ1
I59V
1.62
64.90
2.70
-1.10
Decrease
-0.65
1LZ1
I59V
1.62
64.90
2.70
-1.10
Decrease
-0.65
1LZ1
I59Y
1.62
64.90
2.70
-3.78
Decrease
-2.30
1LZ1
I89A
2.92
64.90
2.70
-2.70
Decrease
-2.30
1LZ1
I89V
2.86
49.20
2.70
-0.35
Decrease
-1.15
1LZ1
I89V
2.92
64.90
2.70
-0.48
Decrease
-1.03
1LZ1
P71G
54.05
68.80
2.80
-1.60
Decrease
-1.47
1LZ1
Q58A
7.22
64.90
2.70
0.91
Decrease
-0.00
1LZ1
Q58G
7.22
64.90
2.70
1.87
Decrease
-1.01
1LZ1
Q58G
7.22
64.90
2.70
1.87
Decrease
-1.01
1LZ1
R21A
63.62
64.90
2.70
1.32
Decrease
0.40
1LZ1
R21G
63.62
64.90
2.70
1.15
Decrease
0.03
1LZ1
R50A
61.62
64.90
2.70
0.43
Increase
0.06
1LZ1
R50G
61.62
64.90
2.70
0.26
Decrease
0.33
1LZ1
R50G
61.62
64.90
2.70
0.26
Decrease
0.33
1LZ1
V74A
60.70
64.90
2.70
-0.36
Decrease
-0.47
1LZ1
V74A
62.39
49.20
2.70
-0.43
Decrease
-0.59
1LZ1
V74D
60.70
64.90
2.70
-0.43
Decrease
-0.33
1LZ1
V74F
60.70
64.90
2.70
-0.29
Decrease
-0.40
1LZ1
V74G
60.70
64.90
2.70
-0.22
Decrease
-0.84
1LZ1
V74I
60.70
64.90
2.70
0.45
Decrease
0.41
1LZ1
V74L
60.70
64.90
2.70
0.19
Decrease
-0.06
1LZ1
V74M
60.70
64.90
2.70
0.65
Decrease
0.05
1LZ1
V74N
60.70
64.90
2.70
-0.33
Decrease
-0.36
1LZ1
V74R
60.70
64.90
2.70
-0.07
Decrease
0.17
1LZ1
V74S
60.70
64.90
2.70
-0.38
Decrease
-0.41
1LZ1
V74S
60.70
64.90
2.70
-0.38
Decrease
-0.41
1LZ1
V74Y
60.70
64.90
2.70
-0.24
Decrease
-0.33
1LZ1
V93A
2.47
64.90
2.70
-0.74
Decrease
-1.00
1LZ1
V93A
2.86
49.20
2.70
-1.00
Decrease
-1.24
1LZ1
V93T
2.47
64.90
2.70
-0.67
Decrease
-1.18
1LZ1
V99A
1.69
64.90
2.70
-0.98
Decrease
-0.36
1LZ1
V99A
2.21
49.20
2.70
-0.89
Decrease
-0.65
1LZ1
V99T
1.69
64.90
2.70
-0.50
Decrease
-0.59
1LZ1
Y20F
23.82
64.90
2.70
-0.50
Decrease
-0.50
1LZ1
Y38A
8.42
64.90
2.70
-2.49
Decrease
-1.68
1LZ1
Y38F
8.42
64.90
2.70
-0.19
Decrease
-0.32
1LZ1
Y38G
8.42
64.90
2.70
-2.32
Decrease
-4.34
1LZ1
Y45F
58.73
64.90
2.70
0.07
Increase
0.24
1LZ1
Y54F
8.19
64.90
2.70
-0.96
Decrease
-1.13
1LZ1
Y63F
52.46
64.90
2.70
-0.24
Decrease
-0.81
1LZ1
D102N
34.84
65.00
2.20
0.17
Decrease
0.21
1LZ1
D102N
34.84
65.00
2.30
0.14
Decrease
0.21
1LZ1
D102N
34.84
65.00
4.00
-0.67
Decrease
0.13
1LZ1
D102N
34.84
65.00
4.50
0.07
Decrease
0.10
1LZ1
D120N
64.33
65.00
2.20
0.10
Increase
0.35
1LZ1
D120N
64.33
65.00
2.30
0.19
Increase
0.34
1LZ1
D120N
64.33
65.00
4.00
-0.67
Increase
0.23
1LZ1
D120N
64.33
65.00
4.50
0.05
Increase
0.19
1LZ1
I106A
2.54
64.90
2.70
-0.93
Decrease
-2.08
1LZ1
I106V
2.54
64.90
2.70
-0.72
Decrease
0.44
1LZ1
I106V
7.03
49.20
2.70
-0.98
Decrease
0.29
1LZ1
N118A
102.25
64.90
2.70
0.19
Increase
-0.13
1LZ1
N118G
102.25
64.90
2.70
0.05
Decrease
-0.08
1LZ1
P103G
103.17
68.80
2.80
-0.10
Decrease
-0.95
1LZ1
V100A
0.59
49.20
2.70
-0.57
Decrease
-1.19
1LZ1
V100A
0.59
64.90
2.70
-0.26
Decrease
-0.93
1LZ1
V100F
0.59
64.90
2.70
-1.65
Decrease
-0.52
1LZ1
V100T
0.59
64.90
2.70
-0.29
Decrease
0.47
1LZ1
V110A
60.12
64.90
2.70
0.53
Increase
-0.10
1LZ1
V110A
61.87
49.20
2.70
0.07
Increase
-0.25
1LZ1
V110D
60.12
64.90
2.70
0.17
Increase
0.11
1LZ1
V110F
60.12
64.90
2.70
-0.05
Increase
-0.07
1LZ1
V110G
60.12
64.90
2.70
0.48
Increase
0.13
1LZ1
V110I
60.12
64.90
2.70
0.86
Increase
1.08
1LZ1
V110L
60.12
64.90
2.70
0.07
Increase
1.02
1LZ1
V110M
60.12
64.90
2.70
0.53
Increase
0.75
1LZ1
V110N
60.12
64.90
2.70
0.07
Increase
-0.24
1LZ1
V110P
60.12
68.80
2.80
0.50
Increase
-0.67
1LZ1
V110R
60.12
64.90
2.70
0.89
Increase
0.55
1LZ1
V110Y
60.12
64.90
2.70
-0.14
Increase
0.49
1LZ1
V121A
10.74
64.90
2.70
-1.44
Decrease
-1.05
1LZ1
V121A
14.18
49.20
2.70
-1.75
Decrease
-1.23
1LZ1
V125A
18.41
64.90
2.70
-1.32
Decrease
-1.06
1LZ1
V125A
20.43
49.20
2.70
-1.60
Decrease
-1.30
1LZ1
V130A
39.43
49.20
2.70
-1.12
Decrease
-1.54
1LZ1
V130A
46.52
64.90
2.70
-0.84
Decrease
-1.16
1LZ1
Y124F
8.75
64.90
2.70
-0.36
Decrease
0.16
1MBG
V103A
0.00
25.00
7.50
-2.32
Decrease
-1.15
1MBG
V103I
0.00
25.00
7.50
0.69
Decrease
0.56
1MBG
V103L
0.00
25.00
7.50
2.44
Decrease
-1.45
1N0J
I58T
57.35
70.00
7.80
-2.70
Decrease
-1.16
1ONC
M23L
0.00
25.00
2.00
-2.51
Decrease
-1.65
1ONC
M23L
0.00
25.00
2.50
-2.30
Decrease
-1.68
1ONC
M23L
0.00
25.00
3.00
-2.78
Decrease
-1.72
1ONC
M23L
0.00
25.00
3.50
-2.89
Decrease
-1.76
1ONC
M23L
0.00
25.00
4.00
-2.42
Decrease
-1.79
1ONC
M23L
0.00
25.00
5.00
-2.66
Decrease
-1.85
1ONC
M23L
0.00
25.00
6.00
-2.66
Decrease
-1.92
1ONC
M23L
0.00
25.00
7.00
-2.22
Decrease
-1.99
1ONC
M23L
0.00
25.00
8.00
-2.39
Decrease
-2.04
1OTR
V5A
0.00
50.00
3.75
-3.01
Decrease
-2.68
1OTR
V5N
0.00
50.00
3.75
-5.38
Decrease
-4.44
1OTR
V5T
0.00
50.00
3.75
-3.73
Decrease
-2.11
1OTR
E34C
41.67
65.00
3.00
0.91
Increase
-0.13
1OTR
E34G
41.67
65.00
3.00
1.39
Increase
-1.23
1OTR
E34H
41.67
65.00
3.00
-3.92
Increase
0.22
1OTR
E34I
41.67
65.00
3.00
1.65
Increase
1.34
1OTR
E34K
41.67
65.00
3.00
-2.15
Increase
0.06
1OTR
E34L
41.67
65.00
3.00
1.36
Increase
-0.03
1OTR
E34P
41.67
65.00
3.00
-2.13
Increase
0.27
1OTR
E34Q
41.67
65.00
3.00
-1.46
Increase
0.47
1OTR
E34S
41.67
65.00
3.00
0.12
Increase
-0.40
1OTR
E34T
41.67
65.00
3.00
1.51
Increase
0.49
1OTR
E34W
41.67
65.00
3.00
1.32
Increase
0.18
1OTR
I30L
0.00
50.00
3.00
-1.96
Decrease
-1.45
1OTR
I36F
15.62
50.00
3.00
-0.86
Decrease
-1.13
1OTR
I36L
15.62
50.00
3.00
-1.32
Decrease
-0.35
1OTR
I36V
15.62
50.00
3.00
-0.79
Decrease
-1.46
1OTR
L67A
0.05
50.00
3.75
-2.82
Decrease
-2.60
1OTR
L67N
0.05
50.00
3.75
-3.40
Decrease
-3.37
1OTR
L67S
0.05
50.00
3.75
-3.30
Decrease
-2.54
1OTR
L67T
0.05
50.00
3.75
-2.92
Decrease
-3.85
1OTR
Q41L
0.11
50.00
3.75
-0.26
Decrease
-0.17
1OTR
Q41N
0.11
50.00
3.75
-2.56
Decrease
-1.68
1OTR
Q41S
0.11
50.00
3.75
-1.27
Decrease
-1.22
1OTR
Q41T
0.11
50.00
3.75
-0.43
Decrease
-1.74
1OTR
Q41V
0.11
50.00
3.75
-0.05
Decrease
-0.15
1OTR
V17A
1.82
50.00
3.75
-1.63
Decrease
-2.43
1OTR
V17N
1.82
50.00
3.75
-4.90
Decrease
-4.06
1OTR
V17T
1.82
50.00
3.75
-1.89
Decrease
-3.10
1PGA
D46A
38.45
25.00
7.00
-1.36
Decrease
-0.23
1PGA
D47A
79.11
25.00
7.00
0.36
Decrease
-0.52
1PGA
K50A
57.17
25.00
7.00
-0.45
Decrease
-0.39
1PGA
T49A
71.16
25.00
7.00
-0.86
Decrease
-0.58
1PGA
T53C
20.98
60.00
5.20
0.78
Increase
0.22
1PGA
T53D
20.98
60.00
5.20
-0.85
Increase
1.08
1PGA
T53E
20.98
60.00
5.20
0.23
Increase
0.84
1PGA
T53F
20.98
60.00
5.20
1.08
Increase
2.95
1PGA
T53G
20.98
60.00
5.20
-1.21
Increase
-0.19
1PGA
T53H
20.98
60.00
5.20
0.37
Increase
-0.26
1PGA
T53I
20.98
60.00
5.20
1.25
Increase
2.56
1PGA
T53K
-29.13
60.00
5.20
0.35
Increase
-0.75
1PGA
T53L
20.98
60.00
5.20
0.45
Increase
0.91
1PGA
T53M
20.98
60.00
5.20
0.90
Increase
1.05
1PGA
T53N
20.98
60.00
5.20
0.52
Increase
0.88
1PGA
T53Q
20.98
60.00
5.20
0.38
Increase
0.02
1PGA
T53R
20.98
60.00
5.20
0.40
Increase
0.47
1PGA
T53S
20.98
60.00
5.20
0.87
Increase
1.45
1PGA
T53T
20.98
60.00
5.20
1.36
Increase
1.25
1PGA
T53V
20.98
60.00
5.20
0.94
Increase
2.29
1PGA
T53W
20.98
60.00
5.20
1.04
Increase
1.01
1PGA
T53Y
20.98
60.00
5.20
1.63
Increase
3.04
1PGA
V54A
0.07
25.00
7.00
-0.10
Decrease
-1.66
1POH
K49A
44.53
25.00
7.00
1.60
Increase
0.23
1POH
K49D
44.53
25.00
7.00
1.80
Increase
0.18
1POH
K49E
44.53
25.00
7.00
2.10
Increase
0.73
1POH
K49E
44.53
30.00
7.00
1.90
Increase
0.72
1POH
K49E
44.53
63.40
7.00
2.10
Increase
0.55
1POH
K49G
44.53
25.00
7.00
1.20
Increase
-0.57
1POH
K49M
44.53
25.00
7.00
1.00
Increase
1.29
1POH
K49N
44.53
25.00
7.00
0.40
Increase
0.88
1POH
K49Q
44.53
25.00
7.00
1.50
Increase
0.76
1POH
K49R
44.53
25.00
7.00
-0.20
Increase
1.08
1POH
K49S
44.53
25.00
7.00
1.20
Increase
1.37
1POH
S46A
27.13
30.00
7.00
-0.90
Increase
1.29
1POH
S46A
27.13
30.00
7.00
-1.10
Increase
1.29
1POH
S46D
27.13
30.00
7.00
1.40
Increase
-0.45
1POH
S46D
27.13
30.00
7.00
1.50
Increase
-0.45
1POH
S46N
27.13
30.00
7.00
0.30
Increase
-0.09
1POH
S46N
27.13
30.00
7.00
0.50
Increase
-0.09
1RN1
N9A
30.05
25.00
7.00
-0.90
Decrease
-1.65
1RN1
N9A
30.05
50.90
7.00
-0.71
Decrease
-1.35
1RN1
A21C
55.44
0.00
2.50
-0.74
Decrease
-0.47
1RN1
A21D
55.44
0.00
2.50
0.33
Decrease
-0.48
1RN1
A21D
55.44
0.00
7.00
-0.71
Decrease
-0.55
1RN1
A21E
55.44
0.00
2.50
0.05
Decrease
-0.30
1RN1
A21E
55.44
0.00
7.00
-0.69
Decrease
-0.42
1RN1
A21F
55.44
0.00
2.50
-0.57
Decrease
-0.07
1RN1
A21G
55.44
0.00
2.50
-0.90
Decrease
-1.21
1RN1
A21H
55.44
0.00
2.50
-0.56
Decrease
-1.21
1RN1
A21H
55.44
0.00
7.00
-0.17
Decrease
-1.32
1RN1
A21I
55.44
0.00
2.50
-0.44
Decrease
-0.34
1RN1
A21K
55.44
0.00
2.50
-0.51
Decrease
-0.31
1RN1
A21L
55.44
0.00
2.50
-0.13
Decrease
0.27
1RN1
A21M
55.44
0.00
2.50
-0.15
Decrease
-0.81
1RN1
A21N
55.44
0.00
2.50
0.34
Decrease
-0.60
1RN1
A21Q
55.44
0.00
2.50
-0.26
Decrease
-0.58
1RN1
A21Q
55.44
0.00
7.00
-0.40
Decrease
-0.69
1RN1
A21R
55.44
0.00
2.50
-0.41
Decrease
-0.43
1RN1
A21S
55.44
0.00
2.50
-0.49
Decrease
-0.52
1RN1
A21S
55.44
0.00
7.00
-0.40
Decrease
-0.73
1RN1
A21T
55.44
0.00
2.50
-0.57
Decrease
-0.75
1RN1
A21V
55.44
0.00
2.50
-0.66
Decrease
0.05
1RN1
A21W
55.44
0.00
2.50
-0.30
Decrease
0.39
1RN1
A21Y
55.44
0.00
2.50
-0.39
Decrease
-0.08
1RN1
D49H
100.49
25.00
7.00
1.10
Decrease
-0.51
1RN1
D76A
2.36
15.00
7.00
-3.70
Decrease
-2.77
1RN1
D76A
2.36
15.00
7.00
-3.80
Decrease
-2.77
1RN1
D76N
2.36
15.00
7.00
-3.10
Decrease
-2.22
1RN1
D76N
2.36
15.00
7.00
-3.10
Decrease
-2.22
1RN1
D76S
2.36
15.00
7.00
-3.10
Decrease
-2.28
1RN1
D76S
2.36
15.00
7.00
-3.30
Decrease
-2.28
1RN1
E58A
4.69
25.00
7.00
-0.77
Decrease
-1.10
1RN1
E58A
4.69
48.60
7.00
-0.78
Decrease
-0.81
1RN1
H40T
36.34
25.00
6.00
-0.26
Decrease
-0.57
1RN1
H92A
21.33
25.00
6.00
-0.62
Decrease
-0.53
1RN1
N36A
46.31
25.00
7.00
0.03
Decrease
-0.91
1RN1
N36A
46.31
50.90
7.00
0.00
Increase
-0.59
1RN1
N44A
33.95
25.00
7.00
-2.08
Decrease
-1.72
1RN1
N44A
33.95
50.80
7.00
-1.60
Decrease
-1.70
1RN1
N44A
33.95
50.90
7.00
-1.86
Decrease
-1.70
1RN1
N44D
33.95
50.80
7.00
-1.60
Decrease
-0.73
1RN1
N44S
33.95
50.80
7.00
-1.50
Decrease
-1.51
1RN1
N81A
3.96
25.00
7.00
-2.87
Decrease
-1.62
1RN1
N81A
3.96
50.90
7.00
-2.91
Decrease
-1.40
1RN1
Q25K
53.08
25.00
7.00
0.94
Decrease
-0.00
1RN1
Q25K
53.08
48.60
7.00
0.93
Increase
0.23
1RN1
S12A
37.46
25.00
7.00
-1.23
Decrease
-1.49
1RN1
S12A
37.46
50.90
7.00
-1.08
Decrease
-1.51
1RN1
S17A
53.50
25.00
7.00
0.67
Decrease
-0.35
1RN1
S17A
53.50
50.90
7.00
0.57
Decrease
-0.18
1RN1
S64A
72.01
25.00
7.00
-1.44
Decrease
-1.25
1RN1
S64A
72.01
50.90
7.00
-1.56
Decrease
-1.11
1RN1
W59Y
0.75
25.00
6.00
-0.93
Decrease
-1.53
1RN1
Y11F
2.76
25.00
7.00
-2.11
Decrease
-1.49
1RN1
Y11F
2.76
50.90
7.00
-2.03
Decrease
-1.43
1RN1
Y24W
16.66
25.00
6.00
1.24
Decrease
-0.43
1RN1
Y42F
6.50
25.00
7.00
1.14
Decrease
-0.77
1RN1
Y42F
6.50
50.90
7.00
1.15
Decrease
-0.74
1RN1
Y42W
6.50
25.00
6.00
-0.14
Decrease
0.25
1RN1
Y45W
59.66
25.00
6.00
0.74
Decrease
-0.87
1RN1
Y56F
11.37
25.00
7.00
-0.78
Decrease
0.46
1RN1
Y56F
11.37
50.90
7.00
-0.71
Decrease
0.51
1RN1
Y57F
6.32
25.00
7.00
-0.50
Decrease
-0.42
1RN1
Y57F
6.32
50.90
7.00
-0.44
Decrease
-0.35
1RN1
Y68F
3.74
25.00
7.00
-1.36
Decrease
-1.16
1RN1
Y68F
3.74
50.90
7.00
-1.35
Decrease
-0.99
1ROP
D30A
87.44
69.00
7.00
0.30
Increase
1.11
1ROP
D30C
87.44
69.00
7.00
0.80
Increase
-0.11
1ROP
D30E
87.44
69.00
7.00
1.00
Increase
0.51
1ROP
D30F
87.44
69.00
7.00
-0.10
Increase
0.53
1ROP
D30G
87.44
69.00
7.00
2.00
Increase
-0.02
1ROP
D30H
87.44
69.00
7.00
0.90
Increase
0.56
1ROP
D30I
87.44
69.00
7.00
-0.80
Increase
0.63
1ROP
D30K
87.44
69.00
7.00
0.90
Increase
0.13
1ROP
D30L
87.44
69.00
7.00
-0.10
Increase
0.63
1ROP
D30M
87.44
69.00
7.00
0.60
Increase
0.35
1ROP
D30N
87.44
69.00
7.00
0.80
Increase
0.61
1ROP
D30P
87.44
69.00
7.00
-1.60
Increase
-0.10
1ROP
D30Q
87.44
69.00
7.00
1.80
Increase
0.26
1ROP
D30R
87.44
69.00
7.00
0.80
Increase
0.62
1ROP
D30S
87.44
69.00
7.00
1.00
Increase
0.05
1ROP
D30T
87.44
69.00
7.00
-0.40
Increase
0.15
1ROP
D30V
87.44
69.00
7.00
-0.40
Increase
0.43
1ROP
D30W
87.44
69.00
7.00
-0.40
Increase
0.67
1ROP
D30Y
87.44
69.00
7.00
0.20
Increase
1.26
1ROP
L41A
46.53
25.00
6.00
-6.12
Decrease
-2.06
1ROP
L41V
46.53
25.00
6.00
-2.53
Decrease
-2.16
1RTB
P93A
73.29
56.05
4.20
-2.70
Decrease
-1.34
1RTB
P93G
73.29
61.60
6.00
-2.20
Decrease
-1.80
1RTB
P93G
73.29
61.80
6.00
-2.60
Decrease
-1.80
1RTB
P93S
73.29
56.05
4.20
-2.10
Decrease
-1.80
1RTB
Y97A
2.95
63.30
5.00
-12.00
Decrease
-4.74
1RTB
Y97F
2.95
63.30
5.00
-3.54
Decrease
-5.85
1RTB
Y97G
2.95
63.30
5.00
-11.70
Decrease
-5.41
1RTB
D121A
8.33
25.00
1.20
-0.72
Decrease
-2.13
1RTB
D121A
8.33
25.00
6.00
-2.20
Decrease
-2.60
1RTB
D121N
8.33
25.00
1.20
-0.76
Decrease
-1.23
1RTB
D121N
8.33
25.00
6.00
-1.90
Decrease
-1.47
1RTB
H119A
38.54
25.00
1.20
1.10
Decrease
-0.67
1RTB
H119A
38.54
25.00
6.00
0.20
Decrease
-0.95
1RTB
P114A
79.00
56.05
4.20
-3.20
Decrease
-1.02
1RTB
P114G
79.00
56.05
4.20
-2.80
Decrease
-1.59
1RTB
P114G
79.00
61.60
6.00
-3.30
Decrease
-1.57
1RTB
P114G
79.00
61.80
6.00
-3.60
Decrease
-1.57
1RX4
L28R
67.72
15.00
7.80
0.50
Decrease
-0.98
1RX4
V75A
7.94
15.00
7.80
-0.20
Decrease
-1.52
1RX4
V75C
7.94
15.00
7.80
-0.20
Decrease
-1.13
1RX4
V75H
7.94
15.00
6.50
-1.90
Decrease
-3.19
1RX4
V75H
7.94
15.00
7.80
-1.70
Decrease
-3.13
1RX4
V75I
7.94
15.00
7.80
-2.00
Decrease
-0.75
1RX4
V75R
7.94
15.00
7.80
-2.80
Decrease
-1.76
1RX4
V75S
7.94
15.00
7.80
-1.90
Decrease
-2.25
1RX4
V75Y
7.94
15.00
7.80
-2.30
Decrease
-1.56
1RX4
V88A
33.77
20.00
7.20
0.20
Decrease
-0.53
1RX4
V88I
33.77
20.00
7.20
-1.73
Decrease
-1.52
1RX4
E139K
42.36
15.00
7.80
-2.36
Decrease
-2.05
1RX4
E139Q
42.36
15.00
7.80
-1.36
Decrease
-0.64
1SAR
D25K
87.86
47.20
7.00
-0.90
Increase
-0.20
1SAR
E74K
80.48
47.20
7.00
-1.10
Decrease
-0.22
1SAR
N39A
11.68
48.40
7.00
-2.20
Decrease
-3.02
1SAR
N39D
11.68
48.40
7.00
-1.50
Decrease
-1.92
1SAR
N39S
11.68
48.40
7.00
-2.30
Decrease
-1.85
1SHG
F52Y
25.36
24.85
7.00
-0.44
Decrease
-0.13
1SHG
K18F
75.94
24.85
7.00
2.33
Increase
0.79
1SHG
K59F
52.65
24.85
7.00
0.92
Increase
0.58
1SHG
K59F
52.65
24.85
7.00
2.51
Increase
0.58
1SHG
K59Y
52.65
24.85
7.00
0.84
Increase
0.04
1SHG
Y13F
55.59
24.85
7.00
2.53
Decrease
-0.17
1SHG
Y13F
55.59
25.00
7.00
0.03
Decrease
-0.16
1SHG
Y57F
35.24
24.85
7.00
2.57
Decrease
-0.11
1SHG
Y57F
35.24
25.00
7.00
0.07
Decrease
-0.11
1STN
A60G
55.08
20.00
7.00
-1.50
Decrease
-1.22
1STN
A60V
55.08
20.00
7.00
-2.90
Increase
0.61
1STN
A90S
0.00
20.00
7.00
-2.00
Decrease
-2.38
1STN
A90S
0.00
47.00
5.00
-2.60
Decrease
-2.23
1STN
A90S
0.00
51.40
7.00
-2.50
Decrease
-2.18
1STN
D77A
2.50
20.00
7.00
-3.20
Decrease
-0.56
1STN
D77G
2.50
20.00
7.00
-2.20
Decrease
-1.70
1STN
D83A
24.71
20.00
7.00
-3.90
Decrease
-1.43
1STN
D83G
24.71
20.00
7.00
-2.80
Decrease
-2.08
1STN
D95A
39.42
20.00
7.00
-3.60
Decrease
-1.26
1STN
D95G
39.42
20.00
7.00
-3.10
Decrease
-1.34
1STN
E73A
26.22
20.00
7.00
-1.60
Decrease
-0.36
1STN
F61A
27.90
20.00
7.00
-2.40
Decrease
-1.69
1STN
F61G
27.90
20.00
7.00
-4.70
Decrease
-2.87
1STN
F76A
8.47
20.00
7.00
-4.10
Decrease
-2.90
1STN
F76G
8.47
20.00
7.00
-4.70
Decrease
-4.63
1STN
G79S
23.63
20.00
7.00
-2.40
Decrease
-0.58
1STN
G79S
23.63
40.00
5.28
-1.80
Decrease
-0.29
1STN
G79S
23.63
47.00
5.00
-1.20
Decrease
-0.19
1STN
G79S
23.63
51.40
7.00
-1.30
Decrease
-0.16
1STN
G88V
0.13
47.00
5.00
0.60
Decrease
-3.32
1STN
G88V
0.13
51.40
7.00
0.50
Decrease
-3.35
1STN
H46Y
21.06
40.00
5.38
0.00
Increase
1.84
1STN
I18G
26.54
20.00
7.00
-2.60
Decrease
-2.46
1STN
I18M
26.54
40.00
5.42
-0.20
Decrease
-0.13
1STN
L25A
0.00
47.00
5.00
-2.80
Decrease
-3.28
1STN
L25A
0.00
51.40
7.00
-2.60
Decrease
-3.18
1STN
L36A
0.00
20.00
7.00
-3.60
Decrease
-3.90
1STN
L36G
0.00
20.00
7.00
-5.40
Decrease
-4.64
1STN
L37A
7.10
20.00
7.00
-1.80
Decrease
-3.07
1STN
L37G
7.10
20.00
7.00
-3.90
Decrease
-4.99
1STN
L89F
14.15
40.00
5.38
-1.20
Decrease
0.89
1STN
T33S
24.59
20.00
7.00
-1.40
Decrease
-0.79
1STN
T62A
0.00
20.00
7.00
-2.40
Decrease
-2.44
1STN
T62G
0.00
20.00
7.00
-3.40
Decrease
-2.98
1STN
V23F
0.13
40.00
5.35
-1.50
Decrease
-2.30
1STN
V66L
1.50
47.00
5.00
0.60
Decrease
-1.10
1STN
V66L
1.50
51.40
7.00
0.80
Decrease
-1.14
1STN
Y91S
0.00
20.00
7.00
-5.30
Decrease
-2.30
1STN
H124L
50.69
40.00
5.20
0.70
Increase
1.27
1STN
H124L
50.69
47.00
5.00
1.90
Increase
1.33
1STN
H124L
50.69
51.40
7.00
1.30
Increase
1.24
1STN
L103A
0.00
20.00
7.00
-4.60
Decrease
-3.20
1STN
N118D
4.99
20.00
7.00
-2.50
Decrease
-1.73
1SUP
M50F
17.04
58.80
8.00
0.48
Decrease
-0.88
1SUP
N76D
61.48
58.80
8.00
0.45
Increase
0.02
1SUP
G169A
0.89
58.80
8.00
0.30
Decrease
-0.93
1SUP
N218S
60.18
58.80
8.00
1.07
Increase
0.58
1SUP
Q206C
36.17
58.80
8.00
1.25
Increase
-0.47
1SUP
Y217K
32.52
58.80
8.00
0.72
Decrease
-2.32
1TPK
V65A
0.13
64.30
4.50
-2.00
Decrease
-1.89
1TPK
V65I
0.13
64.30
4.50
0.30
Decrease
-1.06
1TPK
V65L
0.13
64.30
4.50
-1.90
Decrease
-0.41
1TPK
V65M
0.13
64.30
4.50
-2.20
Decrease
-0.99
1TPK
V65S
0.13
64.30
4.50
-2.40
Decrease
-1.67
1TPK
V65T
0.13
64.30
4.50
-1.00
Decrease
-1.28
1TUP
C242S
13.60
10.00
7.20
-2.94
Decrease
-0.14
1TUP
R175H
2.53
10.00
7.20
-3.01
Decrease
-1.48
1TUP
R248Q
84.76
10.00
7.20
-1.94
Decrease
-0.35
1TUP
R249S
11.48
10.00
7.20
-1.95
Decrease
-2.61
1TUP
R273H
32.05
10.00
7.20
-0.35
Decrease
-2.94
1VQB
I6V
0.59
25.00
7.00
-0.70
Decrease
-0.50
1VQB
A86T
89.29
25.00
7.00
-0.70
Decrease
-0.65
1VQB
A86V
89.29
25.00
7.00
0.50
Decrease
-1.28
1VQB
C33A
0.00
25.00
7.00
-0.50
Decrease
-3.31
1VQB
C33I
0.00
25.00
7.00
-0.90
Decrease
-1.07
1VQB
C33L
0.00
25.00
7.00
-2.60
Decrease
-1.68
1VQB
C33M
0.00
25.00
7.00
-3.50
Decrease
-0.89
1VQB
C33S
0.00
25.00
7.00
-4.20
Decrease
-2.21
1VQB
C33S
0.00
25.00
7.00
-4.30
Decrease
-2.21
1VQB
C33T
0.00
25.00
7.00
-4.60
Decrease
-3.39
1VQB
C33V
0.00
25.00
7.00
-0.20
Decrease
-1.76
1VQB
D36C
34.42
25.00
7.00
-2.00
Decrease
-2.16
1VQB
D36C
34.42
25.00
7.00
-2.10
Decrease
-2.16
1VQB
D36N
34.42
25.00
7.00
-1.00
Decrease
-1.72
1VQB
D50H
28.52
25.00
7.00
-1.50
Decrease
-1.09
1VQB
D50H
28.52
25.00
7.00
-1.60
Decrease
-1.09
1VQB
E30F
16.94
25.00
7.00
2.00
Decrease
0.03
1VQB
E30F
16.94
25.00
7.00
2.10
Decrease
0.03
1VQB
E30M
16.94
25.00
7.00
0.60
Decrease
0.22
1VQB
E30M
16.94
25.00
7.00
0.70
Decrease
0.22
1VQB
E30N
16.94
25.00
7.00
-1.10
Decrease
-0.38
1VQB
E40C
93.59
25.00
7.00
-1.60
Decrease
-0.83
1VQB
E40T
93.59
25.00
7.00
-0.40
Decrease
-0.94
1VQB
F13T
41.26
25.00
7.00
-0.70
Decrease
-2.38
1VQB
F68L
31.39
25.00
7.00
-4.20
Decrease
-2.62
1VQB
F68L
31.39
25.00
7.00
-4.30
Decrease
-2.62
1VQB
F68V
31.39
25.00
7.00
-5.00
Decrease
-2.05
1VQB
F73W
88.24
25.00
7.00
0.80
Decrease
-1.29
1VQB
H64C
43.05
25.00
7.00
0.50
Decrease
-2.01
1VQB
I47A
2.43
25.00
7.00
-7.00
Decrease
-3.87
1VQB
I47A
2.43
25.00
7.00
-7.10
Decrease
-3.87
1VQB
I47C
2.43
25.00
7.00
-5.20
Decrease
-3.83
1VQB
I47C
2.43
25.00
7.00
-5.30
Decrease
-3.83
1VQB
I47F
2.43
25.00
7.00
-1.90
Decrease
-3.38
1VQB
I47F
2.43
25.00
7.00
-2.00
Decrease
-3.38
1VQB
I47L
2.43
25.00
7.00
-0.60
Decrease
-3.11
1VQB
I47L
2.43
25.00
7.00
-0.70
Decrease
-3.11
1VQB
I47M
2.43
25.00
7.00
-2.10
Decrease
-3.62
1VQB
I47M
2.43
25.00
7.00
-2.20
Decrease
-3.62
1VQB
I47T
2.43
25.00
7.00
-7.40
Decrease
-5.03
1VQB
I47V
2.43
25.00
7.00
-2.50
Decrease
-1.67
1VQB
I47V
2.43
25.00
7.00
-2.60
Decrease
-1.67
1VQB
I78C
49.51
25.00
7.00
-4.40
Decrease
-3.43
1VQB
I78T
49.51
25.00
7.00
-6.60
Decrease
-2.87
1VQB
I78V
49.51
25.00
7.00
-1.30
Decrease
-1.22
1VQB
K24V
76.76
25.00
7.00
0.80
Increase
0.18
1VQB
K69H
42.15
25.00
7.00
-1.20
Decrease
-0.72
1VQB
K69H
42.15
25.00
7.00
-1.30
Decrease
-0.72
1VQB
K69M
42.15
25.00
7.00
0.10
Increase
-0.56
1VQB
K69M
42.15
25.00
7.00
0.20
Increase
-0.56
1VQB
L28V
34.35
25.00
7.00
1.10
Decrease
-1.56
1VQB
L32H
43.15
25.00
7.00
-0.90
Decrease
-1.67
1VQB
L32R
43.15
25.00
7.00
-1.60
Decrease
-0.66
1VQB
L32W
43.15
25.00
7.00
2.80
Decrease
-0.49
1VQB
L32Y
43.15
25.00
7.00
1.00
Decrease
-0.60
1VQB
L37A
63.24
25.00
7.00
-7.70
Decrease
-2.55
1VQB
L37C
63.24
25.00
7.00
-4.60
Decrease
-3.33
1VQB
L37I
63.24
25.00
7.00
-1.40
Decrease
-1.74
1VQB
L37T
63.24
25.00
7.00
-5.20
Decrease
-4.08
1VQB
L37V
63.24
25.00
7.00
-3.50
Decrease
-1.29
1VQB
L49A
4.92
25.00
7.00
-6.10
Decrease
-3.20
1VQB
L49C
4.92
25.00
7.00
-4.10
Decrease
-3.55
1VQB
L49I
4.92
25.00
7.00
-1.90
Decrease
-2.04
1VQB
L49T
4.92
25.00
7.00
-5.70
Decrease
-3.36
1VQB
L49V
4.92
25.00
7.00
-2.90
Decrease
-1.40
1VQB
L65P
84.16
25.00
7.00
-1.50
Decrease
-1.64
1VQB
L81C
11.58
25.00
7.00
-3.70
Decrease
-3.22
1VQB
L81T
11.58
25.00
7.00
-5.10
Decrease
-4.90
1VQB
L81V
11.58
25.00
7.00
-0.20
Decrease
-1.56
1VQB
M77A
44.83
25.00
7.00
-2.10
Decrease
-0.55
1VQB
M77C
44.83
25.00
7.00
0.00
Decrease
-1.66
1VQB
M77F
44.83
25.00
7.00
-0.20
Decrease
0.70
1VQB
M77I
44.83
25.00
7.00
1.60
Decrease
-1.12
1VQB
M77L
44.83
25.00
7.00
-1.20
Decrease
-0.47
1VQB
M77T
44.83
25.00
7.00
-0.80
Decrease
-0.60
1VQB
M77V
44.83
25.00
7.00
1.20
Decrease
-0.99
1VQB
R82C
22.14
25.00
7.00
-1.50
Decrease
-1.17
1VQB
S67C
0.00
25.00
7.00
-3.70
Decrease
-1.23
1VQB
S67T
0.00
25.00
7.00
-1.60
Decrease
-2.29
1VQB
T48C
13.84
25.00
7.00
-0.80
Decrease
-1.16
1VQB
T48V
13.84
25.00
7.00
0.00
Decrease
-0.89
1VQB
T62C
39.37
25.00
7.00
-0.70
Decrease
-1.00
1VQB
T62V
39.37
25.00
7.00
1.30
Decrease
-0.63
1VQB
V19C
65.71
25.00
7.00
-0.30
Decrease
-2.27
1VQB
V19T
65.71
25.00
7.00
-0.60
Decrease
-1.67
1VQB
V35A
5.53
25.00
7.00
-2.20
Decrease
-2.34
1VQB
V35A
5.53
25.00
7.00
-2.20
Decrease
-2.34
1VQB
V35C
5.53
25.00
7.00
-1.40
Decrease
-2.53
1VQB
V35C
5.53
25.00
7.00
-1.40
Decrease
-2.53
1VQB
V35F
5.53
25.00
7.00
-3.10
Decrease
-1.58
1VQB
V35F
5.53
25.00
7.00
-3.20
Decrease
-1.58
1VQB
V35I
5.53
25.00
7.00
-0.60
Decrease
-0.75
1VQB
V35I
5.53
25.00
7.00
-0.70
Decrease
-0.75
1VQB
V35L
5.53
25.00
7.00
-2.70
Decrease
-2.22
1VQB
V35L
5.53
25.00
7.00
-2.70
Decrease
-2.22
1VQB
V35M
5.53
25.00
7.00
-1.00
Decrease
-2.61
1VQB
V35M
5.53
25.00
7.00
-1.10
Decrease
-2.61
1VQB
V35T
5.53
25.00
7.00
-5.30
Decrease
-3.70
1VQB
V43C
36.11
25.00
7.00
-2.10
Decrease
-0.89
1VQB
V43T
36.11
25.00
7.00
-1.60
Decrease
-3.15
1VQB
V45A
32.27
25.00
7.00
-2.10
Decrease
-2.66
1VQB
V45C
32.27
25.00
7.00
-0.10
Decrease
-1.96
1VQB
V45L
32.27
25.00
7.00
-3.00
Decrease
-2.07
1VQB
V45T
32.27
25.00
7.00
-3.50
Decrease
-2.89
1VQB
V63C
15.35
25.00
7.00
-4.10
Decrease
-2.73
1VQB
V63T
15.35
25.00
7.00
-5.00
Decrease
-4.47
1VQB
V70C
68.05
25.00
7.00
-3.10
Decrease
-1.74
1VQB
V70C
68.05
25.00
7.00
-3.30
Decrease
-1.74
1VQB
V70P
68.05
25.00
7.00
-5.00
Decrease
-2.65
1VQB
V70P
68.05
25.00
7.00
-5.10
Decrease
-2.65
1VQB
V70T
68.05
25.00
7.00
-3.50
Decrease
-1.47
1VQB
Y26R
38.32
25.00
7.00
-0.40
Decrease
-0.69
1VQB
Y41A
79.60
25.00
7.00
-0.40
Decrease
-1.66
1VQB
Y41F
79.60
25.00
7.00
-0.60
Decrease
0.38
1YCC
F82Y
17.64
25.00
6.00
-0.70
Decrease
-0.25
1YCC
K73I
83.62
25.00
4.50
-0.40
Increase
0.94
1YCC
K73V
83.62
25.00
4.50
0.10
Increase
0.08
1YCC
K73W
83.62
25.00
4.50
-1.60
Increase
0.86
1YCC
L85A
4.81
25.00
6.00
-2.80
Decrease
-2.45
1YCC
N52A
11.48
26.85
4.60
0.63
Decrease
-0.51
1YCC
N52H
11.48
26.85
4.60
-1.27
Increase
0.06
1YCC
N52I
11.48
26.85
3.50
2.62
Increase
1.40
1YCC
N52I
11.48
26.85
4.00
3.03
Increase
1.39
1YCC
N52I
11.48
26.85
4.60
3.14
Increase
1.38
1YCC
N52I
11.48
26.85
5.00
2.02
Increase
1.36
1YCC
N52I
11.48
46.50
6.00
4.30
Increase
1.67
1YCC
N52I
19.60
37.00
4.60
3.14
Increase
1.68
1YCC
N52L
11.48
26.85
4.60
2.56
Increase
1.17
1YCC
N52M
11.48
26.85
4.00
2.91
Increase
1.31
1YCC
N52M
11.48
26.85
4.60
2.25
Increase
1.31
1YCC
N52Q
11.48
26.85
4.60
-0.08
Increase
0.00
1YCC
N52S
11.48
26.85
4.00
0.74
Increase
-0.11
1YCC
N52S
11.48
26.85
4.60
-0.05
Increase
-0.11
1YCC
N52S
11.48
26.85
5.00
-1.29
Increase
-0.11
1YCC
N52T
11.48
26.85
3.50
0.98
Increase
0.55
1YCC
N52T
11.48
26.85
4.00
1.01
Increase
0.54
1YCC
N52T
11.48
26.85
4.60
0.59
Increase
0.52
1YCC
N52T
11.48
26.85
5.00
-0.53
Increase
0.51
1YCC
N52V
11.48
26.85
4.00
2.44
Increase
0.67
1YCC
N52V
11.48
26.85
4.60
1.67
Increase
0.65
1YCC
P76G
70.82
25.00
4.60
-0.78
Decrease
-2.48
1YCC
P76L
70.82
25.00
4.60
-3.44
Decrease
0.66
1YCC
P76R
70.82
25.00
4.60
-0.97
Decrease
-1.78
1YCC
P76S
70.82
25.00
4.60
-1.89
Decrease
-2.09
1YCC
P76V
70.82
25.00
4.60
-1.07
Decrease
-1.83
1YCC
P76W
70.82
25.00
4.60
-2.38
Decrease
-1.13
1YCC
P76Y
70.82
25.00
4.60
-2.07
Decrease
-0.74
1YCC
C102A
0.85
46.50
6.00
2.90
Decrease
0.63
1YCC
C102S
0.85
46.50
6.00
2.80
Increase
-0.44
1YCC
C102T
0.85
51.40
4.70
0.50
Increase
2.06
1YCC
C102T
0.85
51.40
4.70
5.30
Increase
2.06
1YCC
C102T
0.85
57.10
6.00
0.80
Increase
2.10
1YCC
C102T
0.85
57.10
6.00
5.70
Increase
2.10
2ABD
A9G
8.17
5.00
5.30
-1.81
Decrease
-1.24
2ABD
F5A
0.00
5.00
5.30
-2.52
Decrease
-2.03
2ABD
A34G
6.35
5.00
5.30
-1.57
Decrease
-2.42
2ABD
D21A
18.46
5.00
5.30
0.42
Decrease
-1.69
2ABD
D21H
18.46
5.00
5.30
-0.56
Decrease
-0.83
2ABD
E67A
55.70
5.00
5.30
-0.36
Decrease
-0.89
2ABD
K32A
25.13
5.00
5.30
-1.02
Decrease
-1.28
2ABD
K32E
25.13
5.00
5.30
-1.68
Decrease
-1.69
2ABD
K32R
25.13
5.00
5.30
-1.83
Decrease
-0.67
2ABD
K52M
36.17
5.00
5.30
0.18
Increase
-0.09
2ABD
K54A
36.17
5.00
5.30
-0.86
Decrease
-0.36
2ABD
K54M
36.17
5.00
5.30
0.27
Increase
0.02
2ABD
L15A
0.33
5.00
5.30
-3.10
Decrease
-2.91
2ABD
L25A
8.74
5.00
5.30
-1.02
Decrease
-2.83
2ABD
L80A
1.80
5.00
5.30
-3.70
Decrease
-2.91
2ABD
P19A
4.51
5.00
5.30
-1.07
Decrease
-2.08
2ABD
P44A
35.66
5.00
5.30
-1.40
Decrease
-0.74
2ABD
Q33A
0.73
5.00
5.30
-3.66
Decrease
-0.09
2ABD
T35A
36.70
5.00
5.30
-1.09
Decrease
-1.04
2ABD
V12A
5.14
5.00
5.30
-1.69
Decrease
-1.49
2ABD
V77A
2.34
5.00
5.30
-1.14
Decrease
-1.55
2ABD
Y28A
24.85
5.00
5.30
-2.47
Decrease
-4.71
2ABD
Y28F
24.85
5.00
5.30
-1.06
Increase
0.77
2ABD
Y28N
24.85
5.00
5.30
-2.23
Decrease
-1.70
2ABD
Y31N
26.20
5.00
5.30
-1.52
Decrease
-2.35
2ABD
Y73A
1.59
5.00
5.30
-4.83
Decrease
-1.66
2ABD
Y73F
1.59
5.00
5.30
0.27
Decrease
-2.46
2AFG
L44P
0.00
40.05
6.60
0.69
Decrease
-2.40
2AFG
L73V
3.93
40.05
6.60
-1.46
Decrease
-1.66
2AFG
V109L
0.33
40.05
6.60
-0.57
Decrease
-0.81
2AKY
V8I
0.39
25.00
7.50
-1.20
Decrease
-0.05
2AKY
T77H
73.04
25.00
7.50
-2.15
Decrease
0.07
2AKY
I213F
0.00
25.00
7.50
-1.91
Decrease
-2.45
2AKY
N169D
49.66
25.00
7.50
-2.15
Decrease
-1.03
2CI2
A35G
0.00
25.00
6.25
-1.09
Decrease
-2.59
2CI2
A77G
40.02
25.00
6.30
-1.88
Decrease
-1.76
2CI2
D42A
41.78
25.00
6.25
-0.96
Decrease
-0.93
2CI2
D64A
21.24
25.00
6.25
-0.80
Decrease
-2.27
2CI2
D71A
40.94
25.00
6.25
-3.41
Decrease
-1.24
2CI2
E26A
50.20
25.00
6.25
-0.47
Decrease
-0.47
2CI2
E26Q
50.20
25.00
6.25
-0.62
Decrease
-0.24
2CI2
E33D
56.84
25.00
6.25
-0.52
Decrease
-0.76
2CI2
E33N
56.84
25.00
6.25
-0.70
Decrease
-1.34
2CI2
E33N
56.84
46.45
6.30
-0.70
Decrease
-1.31
2CI2
E33Q
56.84
25.00
6.25
-0.29
Decrease
-0.71
2CI2
E34D
50.72
25.00
6.25
-0.74
Decrease
-0.58
2CI2
E34N
50.72
25.00
6.25
-1.07
Decrease
-0.78
2CI2
E34Q
50.72
25.00
6.25
-0.47
Decrease
-0.38
2CI2
E45A
54.49
25.00
6.25
-0.32
Decrease
-0.82
2CI2
E45A
54.49
74.30
4.15
0.82
Decrease
0.20
2CI2
E60A
52.83
25.00
6.25
-0.70
Decrease
-0.25
2CI2
E60A
52.83
25.00
6.30
-0.68
Decrease
-0.25
2CI2
F69A
17.19
25.00
6.25
-3.84
Decrease
-3.38
2CI2
F69L
17.19
25.00
6.25
-2.11
Decrease
-2.59
2CI2
F69L
17.19
46.45
6.30
-2.11
Decrease
-2.39
2CI2
F69V
17.19
25.00
6.25
-2.39
Decrease
-2.31
2CI2
I39V
0.00
25.00
3.00
-1.20
Decrease
-0.37
2CI2
I39V
0.00
25.00
3.50
-1.16
Decrease
-0.36
2CI2
I39V
0.00
25.00
6.25
-1.30
Decrease
-0.32
2CI2
I39V
0.00
25.00
6.30
-1.27
Decrease
-0.32
2CI2
I39V
0.00
46.45
6.30
-1.30
Decrease
-0.30
2CI2
I48A
18.27
25.00
3.50
-3.89
Decrease
-4.13
2CI2
I48A
18.27
25.00
6.30
-3.84
Decrease
-4.20
2CI2
I48V
18.27
25.00
3.50
-0.92
Decrease
-0.31
2CI2
I48V
18.27
25.00
6.30
-1.09
Decrease
-0.29
2CI2
I48V
18.27
46.45
6.30
-1.11
Decrease
-0.19
2CI2
I49A
40.70
25.00
6.30
-2.12
Decrease
-2.11
2CI2
I49A
40.70
46.45
6.30
-2.12
Decrease
-1.93
2CI2
I49G
40.70
25.00
6.30
-3.52
Decrease
-2.61
2CI2
I49T
40.70
25.00
6.30
-1.34
Decrease
-3.30
2CI2
I49V
40.70
25.00
6.30
0.08
Decrease
-0.68
2CI2
I49V
40.70
46.45
6.30
0.08
Decrease
-0.59
2CI2
I56A
94.49
25.00
6.25
-0.03
Decrease
-0.65
2CI2
I76A
0.54
25.00
3.00
-4.23
Decrease
-3.77
2CI2
I76A
0.54
25.00
3.50
-4.34
Decrease
-3.80
2CI2
I76A
0.54
25.00
6.30
-4.25
Decrease
-3.90
2CI2
I76V
0.54
25.00
3.00
0.09
Decrease
-0.95
2CI2
I76V
0.54
25.00
6.30
0.21
Decrease
-1.15
2CI2
I76V
0.54
46.45
6.30
0.19
Decrease
-1.16
2CI2
K21A
41.37
25.00
6.25
-0.55
Decrease
-0.46
2CI2
K21M
41.37
25.00
6.25
-0.67
Increase
0.16
2CI2
K30A
41.23
25.00
6.25
0.42
Decrease
-0.09
2CI2
K36A
43.90
25.00
6.25
-0.49
Decrease
-0.29
2CI2
K36A
43.90
46.45
6.30
-0.49
Decrease
-0.19
2CI2
K36G
43.90
25.00
6.25
-2.32
Decrease
-1.80
2CI2
K37A
67.57
25.00
6.25
0.21
Decrease
0.15
2CI2
K37A
67.57
46.45
6.30
0.23
Decrease
0.15
2CI2
K37G
67.57
25.00
6.25
-0.99
Decrease
-0.30
2CI2
K37G
67.57
46.45
6.30
-0.97
Decrease
-0.06
2CI2
K43A
4.38
25.00
6.25
-0.65
Decrease
-2.17
2CI2
K43A
4.38
46.45
6.30
-0.65
Decrease
-1.83
2CI2
K43A
4.38
74.30
4.15
0.26
Decrease
-1.26
2CI2
K43G
4.38
25.00
6.25
-3.19
Decrease
-1.81
2CI2
K72N
101.22
25.00
6.25
0.00
Increase
-0.10
2CI2
L27A
0.49
25.00
3.00
-2.66
Decrease
-2.94
2CI2
L27A
0.49
25.00
6.30
-2.64
Decrease
-3.01
2CI2
L27A
0.49
46.45
6.30
-2.68
Decrease
-2.81
2CI2
L40A
43.53
25.00
6.25
-1.33
Decrease
-1.87
2CI2
L40G
43.53
25.00
6.25
-1.38
Decrease
-1.79
2CI2
L51A
21.25
25.00
6.25
-2.37
Decrease
-2.11
2CI2
L51A
21.25
46.45
6.30
-2.37
Decrease
-1.89
2CI2
L51I
21.25
25.00
6.25
-0.26
Decrease
-0.86
2CI2
L51V
21.25
25.00
6.25
-0.50
Decrease
-1.52
2CI2
L51V
21.25
46.45
6.30
-0.50
Decrease
-1.49
2CI2
L68A
0.05
25.00
3.50
-3.74
Decrease
-3.58
2CI2
L68A
0.05
25.00
6.30
-3.82
Decrease
-3.66
2CI2
N75A
28.35
25.00
6.25
-0.83
Decrease
-1.23
2CI2
N75D
28.35
25.00
6.25
-1.21
Decrease
-1.59
2CI2
P25A
50.18
25.00
6.25
-1.57
Decrease
-0.55
2CI2
P44A
77.17
25.00
6.25
-1.76
Decrease
-1.28
2CI2
P44A
77.17
74.30
4.15
1.82
Decrease
-0.90
2CI2
P52A
61.38
25.00
6.25
-0.17
Decrease
-1.99
2CI2
P80A
2.61
25.00
6.25
-3.34
Decrease
-2.43
2CI2
Q41A
78.16
25.00
6.25
-0.02
Decrease
-0.40
2CI2
Q41G
78.16
25.00
6.25
-0.60
Decrease
-0.44
2CI2
R62A
49.69
25.00
6.25
-0.58
Decrease
-0.30
2CI2
S31A
20.48
25.00
3.00
1.00
Decrease
0.60
2CI2
S31A
20.48
25.00
6.25
-0.89
Decrease
0.33
2CI2
S31A
20.48
46.45
6.30
-0.89
Decrease
0.42
2CI2
S31G
20.48
25.00
3.50
0.84
Decrease
-2.18
2CI2
S31G
20.48
25.00
6.25
-0.80
Decrease
-2.37
2CI2
T22A
38.57
25.00
6.30
-0.85
Decrease
-0.69
2CI2
T22A
38.57
46.45
6.30
-0.85
Decrease
-0.47
2CI2
T22G
38.57
25.00
6.30
-1.16
Decrease
-1.47
2CI2
T22V
38.57
25.00
6.30
-0.32
Decrease
-0.36
2CI2
T55A
41.17
25.00
6.25
0.23
Decrease
-1.27
2CI2
T55S
41.17
25.00
6.25
-0.02
Decrease
-0.39
2CI2
T55V
41.17
25.00
6.25
-0.76
Decrease
1.04
2CI2
T58A
76.78
25.00
6.30
-0.69
Decrease
0.19
2CI2
T58D
76.78
25.00
6.30
0.04
Decrease
-0.03
2CI2
V38A
34.03
25.00
3.00
-0.46
Decrease
-0.63
2CI2
V38A
34.03
25.00
6.25
-0.49
Decrease
-0.62
2CI2
V38A
34.03
25.00
6.30
-0.46
Decrease
-0.62
2CI2
V38A
34.03
46.45
6.30
-0.48
Decrease
-0.45
2CI2
V53A
50.68
25.00
6.30
-0.64
Decrease
-0.57
2CI2
V53A
50.68
46.45
6.30
-0.63
Decrease
-0.58
2CI2
V53G
50.68
25.00
6.30
-2.43
Decrease
-2.79
2CI2
V53T
50.68
25.00
6.30
-1.03
Decrease
-1.07
2CI2
V53T
50.68
46.45
6.30
-1.03
Decrease
-0.95
2CI2
V57A
40.27
25.00
6.25
-1.47
Decrease
-1.55
2CI2
V66A
0.00
25.00
3.50
-4.91
Decrease
-2.10
2CI2
V66A
0.00
25.00
6.30
-4.88
Decrease
-2.10
2CI2
V70A
7.87
25.00
3.00
-2.17
Decrease
-2.11
2CI2
V70A
7.87
25.00
6.30
-1.95
Decrease
-2.29
2CI2
V70A
7.87
46.45
6.30
-1.95
Decrease
-2.22
2CI2
V79A
25.63
25.00
6.30
-1.51
Decrease
-1.37
2CI2
V79G
25.63
25.00
6.30
-3.24
Decrease
-3.44
2CI2
V79T
25.63
25.00
6.30
-0.38
Decrease
-1.40
2CI2
V82A
11.58
25.00
6.30
-1.45
Decrease
-2.46
2CI2
V82G
11.58
25.00
6.30
-3.50
Decrease
-2.57
2CI2
V82T
11.58
25.00
6.30
-1.15
Decrease
-1.13
2HPR
G49A
23.76
25.00
7.00
0.80
Decrease
-1.34
2HPR
G49E
23.76
25.00
7.00
1.40
Decrease
-1.00
2HPR
G49K
23.76
25.00
7.00
-1.00
Decrease
-1.82
2LZM
I3A
10.70
41.90
2.00
-1.10
Decrease
-1.57
2LZM
I3A
10.70
64.70
6.50
-0.70
Decrease
-1.69
2LZM
I3C
10.70
41.90
2.00
1.00
Decrease
-2.07
2LZM
I3C
10.70
41.90
2.00
-0.40
Decrease
-2.07
2LZM
I3C
10.70
64.70
6.50
1.20
Decrease
-2.14
2LZM
I3C
10.70
64.70
6.50
-1.20
Decrease
-2.14
2LZM
I3D
10.70
41.90
2.00
-1.80
Decrease
-2.27
2LZM
I3D
10.70
64.70
6.50
-3.20
Decrease
-2.50
2LZM
I3E
10.70
38.75
2.00
-1.77
Decrease
-1.75
2LZM
I3E
10.70
41.90
2.00
-1.10
Decrease
-1.75
2LZM
I3E
10.70
46.16
2.50
-1.71
Decrease
-1.79
2LZM
I3E
10.70
53.56
3.00
-1.53
Decrease
-1.84
2LZM
I3E
10.70
64.70
6.50
-2.00
Decrease
-2.08
2LZM
I3F
10.70
38.75
2.00
-1.49
Decrease
-0.32
2LZM
I3F
10.70
41.90
2.00
-1.00
Decrease
-0.31
2LZM
I3F
10.70
46.16
2.50
-1.09
Decrease
-0.32
2LZM
I3F
10.70
53.56
3.00
-0.53
Decrease
-0.34
2LZM
I3F
10.70
64.70
6.50
-1.10
Decrease
-0.47
2LZM
I3G
10.70
41.90
2.00
-1.80
Decrease
-3.37
2LZM
I3G
10.70
64.70
6.50
-2.10
Decrease
-3.54
2LZM
I3L
10.70
38.75
2.00
0.85
Decrease
0.01
2LZM
I3L
10.70
41.90
2.00
0.90
Decrease
0.01
2LZM
I3L
10.70
46.16
2.50
1.01
Decrease
0.01
2LZM
I3L
10.70
53.42
3.00
0.83
Decrease
-0.01
2LZM
I3L
10.70
53.56
3.00
1.16
Decrease
-0.01
2LZM
I3L
10.70
64.70
6.50
0.40
Decrease
-0.13
2LZM
I3L
10.70
66.51
5.40
0.70
Decrease
-0.09
2LZM
I3M
10.70
41.90
2.00
-0.30
Decrease
-0.93
2LZM
I3M
10.70
64.70
6.50
-0.90
Decrease
-0.95
2LZM
I3P
10.70
38.75
2.00
-2.96
Decrease
-2.44
2LZM
I3P
10.70
46.16
2.50
-2.97
Decrease
-2.45
2LZM
I3P
10.70
53.56
3.00
-2.53
Decrease
-2.45
2LZM
I3S
10.70
41.90
2.00
-1.90
Decrease
-2.10
2LZM
I3S
10.70
64.70
6.50
-1.70
Decrease
-2.03
2LZM
I3T
10.70
38.75
2.00
-2.45
Decrease
-1.72
2LZM
I3T
10.70
41.90
2.00
-1.70
Decrease
-1.71
2LZM
I3T
10.70
46.16
2.50
-2.28
Decrease
-1.74
2LZM
I3T
10.70
53.56
3.00
-1.81
Decrease
-1.78
2LZM
I3T
10.70
64.70
6.50
-2.30
Decrease
-2.08
2LZM
I3V
10.70
41.90
2.00
-0.60
Decrease
-0.33
2LZM
I3V
10.70
64.70
6.50
-0.40
Decrease
-0.35
2LZM
I3W
10.70
64.70
6.50
-2.80
Decrease
-0.88
2LZM
I3Y
10.70
41.90
2.00
-2.70
Decrease
-1.37
2LZM
I3Y
10.70
64.70
6.50
-2.30
Decrease
-1.61
2LZM
L7A
0.00
51.65
3.00
-2.60
Decrease
-3.06
2LZM
M6A
0.00
51.65
3.00
-1.90
Decrease
-2.90
2LZM
M6I
0.00
65.50
6.00
-1.38
Decrease
-2.40
2LZM
M6L
0.00
47.00
3.00
-2.80
Decrease
-0.95
2LZM
A41D
35.39
65.15
5.40
0.29
Decrease
-0.36
2LZM
A41S
35.39
51.55
3.00
-0.60
Decrease
-0.46
2LZM
A41V
35.39
41.47
2.03
0.42
Decrease
-1.10
2LZM
A41V
35.39
51.10
2.83
0.45
Decrease
-0.93
2LZM
A41V
35.39
53.42
3.00
0.41
Decrease
-0.90
2LZM
A41V
35.39
66.51
5.40
0.30
Decrease
-0.71
2LZM
A42K
0.00
53.00
5.45
-3.70
Decrease
-1.42
2LZM
A42S
0.00
51.55
3.00
-2.30
Decrease
-1.15
2LZM
A49S
42.92
51.55
3.00
-0.50
Decrease
-0.35
2LZM
A73S
46.28
51.55
3.00
-0.40
Decrease
-0.92
2LZM
A74P
7.80
57.50
3.50
-5.70
Decrease
-0.85
2LZM
A74P
7.80
62.20
4.00
-5.00
Decrease
-0.82
2LZM
A74P
7.80
62.90
6.50
-4.60
Decrease
-0.93
2LZM
A74P
7.80
65.70
5.50
-4.50
Decrease
-0.86
2LZM
A82P
81.22
38.80
2.00
-0.07
Increase
-0.94
2LZM
A82P
81.22
41.90
2.00
0.30
Increase
-0.90
2LZM
A82P
81.22
41.90
2.00
0.30
Increase
-0.90
2LZM
A82P
81.22
46.20
2.50
0.51
Increase
-0.85
2LZM
A82P
81.22
53.42
3.00
0.45
Increase
-0.79
2LZM
A82P
81.22
53.60
3.00
1.27
Increase
-0.79
2LZM
A82P
81.22
64.70
6.50
0.80
Increase
-0.85
2LZM
A82P
81.22
64.70
6.50
0.80
Increase
-0.85
2LZM
A82P
81.22
66.51
5.40
0.57
Increase
-0.76
2LZM
A82S
81.22
51.55
3.00
-0.30
Decrease
0.20
2LZM
A93P
68.33
46.20
2.50
0.51
Increase
-2.07
2LZM
A93P
68.33
53.60
3.00
1.10
Increase
-1.93
2LZM
A93P
68.87
38.80
2.00
0.03
Increase
-2.23
2LZM
A93P
68.87
41.90
2.00
0.10
Increase
-2.17
2LZM
A93P
68.87
64.70
6.50
0.10
Increase
-1.68
2LZM
A93S
68.87
51.55
3.00
-0.20
Decrease
0.43
2LZM
A93T
68.87
65.15
5.40
0.06
Decrease
-0.58
2LZM
A98S
0.00
51.55
3.00
-2.50
Decrease
-3.62
2LZM
A98V
0.00
40.00
3.00
-4.90
Decrease
-0.22
2LZM
C54T
2.64
65.50
6.00
1.36
Increase
-1.01
2LZM
C54T
2.64
70.00
6.50
0.30
Increase
-0.97
2LZM
C54V
2.64
70.00
6.50
-0.70
Increase
0.50
2LZM
D20A
32.06
65.10
5.40
-0.30
Decrease
-0.76
2LZM
D20N
32.06
65.10
5.40
1.30
Decrease
-0.50
2LZM
D20S
32.06
65.10
5.40
0.70
Increase
0.34
2LZM
D20T
32.06
65.10
5.40
0.90
Increase
0.75
2LZM
D47A
24.71
51.65
3.00
-0.28
Decrease
-0.79
2LZM
D47A
24.71
62.20
6.70
-0.95
Decrease
-0.51
2LZM
D72P
47.88
38.50
2.00
-2.60
Decrease
-2.28
2LZM
D72P
47.88
63.40
6.50
-2.70
Decrease
-2.24
2LZM
D92N
43.86
39.50
2.00
-0.10
Decrease
-0.51
2LZM
D92N
43.86
62.40
6.70
-1.40
Decrease
-0.27
2LZM
E11A
18.89
66.48
5.40
1.10
Decrease
0.55
2LZM
E11F
18.89
66.48
5.40
1.70
Increase
1.95
2LZM
E11H
18.89
65.10
5.40
0.10
Decrease
-1.35
2LZM
E11M
18.89
66.48
5.40
1.60
Increase
1.29
2LZM
E11N
18.89
65.10
5.40
-0.10
Increase
-0.48
2LZM
E22K
47.97
65.15
5.40
0.57
Decrease
-0.48
2LZM
E45A
30.57
51.65
3.00
0.55
Decrease
-0.79
2LZM
E45A
30.57
62.20
6.70
0.01
Decrease
-0.73
2LZM
F67A
5.23
51.65
3.00
-1.90
Decrease
-3.45
2LZM
G30A
21.98
66.48
5.40
0.10
Decrease
-1.34
2LZM
G30F
21.98
66.48
5.40
-1.50
Decrease
0.26
2LZM
G77A
4.83
41.90
2.00
-0.40
Decrease
-1.21
2LZM
G77A
4.83
41.90
2.00
-0.40
Decrease
-1.21
2LZM
G77A
4.83
64.70
6.50
0.40
Decrease
-1.02
2LZM
G77A
4.83
64.70
6.50
0.40
Decrease
-1.02
2LZM
H31N
18.80
66.00
5.50
-4.00
Decrease
-1.04
2LZM
I17A
11.03
51.65
3.00
-2.70
Decrease
-2.91
2LZM
I27A
0.00
51.65
3.00
-3.10
Decrease
-3.85
2LZM
I29A
2.11
51.65
3.00
-2.60
Decrease
-2.53
2LZM
I50A
18.00
51.65
3.00
-2.00
Decrease
-2.96
2LZM
I58A
2.22
51.65
3.00
-3.20
Decrease
-2.46
2LZM
I58T
2.22
59.00
5.40
-3.40
Decrease
-1.48
2LZM
I78A
0.00
51.65
3.00
-1.60
Decrease
-3.38
2LZM
I78M
0.00
65.30
5.42
-1.50
Decrease
-1.01
2LZM
K16E
58.39
50.90
2.80
-0.50
Increase
0.04
2LZM
K16E
58.39
66.70
5.30
0.50
Increase
0.01
2LZM
K43A
23.33
51.65
3.00
-0.96
Decrease
-0.36
2LZM
K43A
23.33
53.00
5.45
-1.10
Decrease
-0.45
2LZM
K43A
23.33
62.20
6.70
-1.03
Decrease
-0.39
2LZM
K48A
73.46
51.65
3.00
-0.32
Increase
0.38
2LZM
K48A
73.46
62.20
6.70
-0.56
Increase
0.39
2LZM
K60H
52.02
28.50
2.00
-0.80
Decrease
-0.98
2LZM
K60H
52.02
63.00
6.50
-0.10
Decrease
-0.76
2LZM
K60P
52.36
41.90
2.00
0.10
Increase
-1.06
2LZM
K60P
52.36
64.70
6.50
0.00
Increase
-0.87
2LZM
K83H
64.17
28.50
2.00
-0.50
Decrease
-0.24
2LZM
K83H
64.17
63.00
6.50
-0.40
Decrease
0.32
2LZM
L33A
9.12
51.65
3.00
-3.60
Decrease
-2.50
2LZM
L39A
44.89
53.00
5.45
-0.90
Decrease
-2.31
2LZM
L46A
0.00
51.65
3.00
-2.62
Decrease
-4.44
2LZM
L46A
0.00
51.80
3.01
-2.70
Decrease
-4.44
2LZM
L46A
0.00
53.00
5.45
-2.10
Decrease
-4.41
2LZM
L46A
0.00
62.20
6.70
-1.86
Decrease
-4.16
2LZM
L66A
1.64
51.65
3.00
-3.90
Decrease
-2.06
2LZM
L84A
0.00
51.65
3.00
-3.90
Decrease
-4.45
2LZM
L84M
0.00
65.30
5.42
-1.90
Decrease
-1.01
2LZM
L91A
2.84
51.65
3.00
-3.10
Decrease
-3.28
2LZM
L91M
2.84
65.30
5.42
-0.80
Decrease
-0.95
2LZM
L99A
0.00
51.70
3.00
-4.60
Decrease
-3.52
2LZM
L99A
0.00
51.76
3.01
-5.00
Decrease
-3.52
2LZM
L99A
0.00
51.80
3.01
-5.00
Decrease
-3.52
2LZM
L99A
0.00
64.88
5.70
-4.50
Decrease
-3.24
2LZM
L99A
0.00
65.20
5.40
-4.00
Decrease
-3.23
2LZM
L99F
0.00
51.76
3.01
-0.40
Decrease
-2.35
2LZM
L99F
0.00
64.88
5.70
-0.30
Decrease
-2.27
2LZM
L99G
0.00
51.70
3.00
-7.40
Decrease
-4.85
2LZM
L99G
0.00
65.20
5.40
-6.30
Decrease
-4.79
2LZM
L99I
0.00
51.76
3.01
-1.40
Decrease
-1.34
2LZM
L99I
0.00
64.88
5.70
-1.50
Decrease
-1.16
2LZM
L99M
0.00
51.76
3.01
-0.70
Decrease
-1.78
2LZM
L99M
0.00
64.88
5.70
-0.60
Decrease
-1.59
2LZM
L99M
0.00
65.30
5.42
-0.40
Decrease
-1.60
2LZM
L99V
0.00
51.76
3.01
-2.30
Decrease
-1.44
2LZM
L99V
0.00
64.88
5.70
-2.00
Decrease
-1.38
2LZM
N40A
74.39
51.65
3.00
0.43
Increase
-0.04
2LZM
N40A
74.39
53.00
5.45
0.20
Increase
-0.06
2LZM
N40A
74.39
62.20
6.70
0.32
Increase
0.01
2LZM
N40D
74.39
65.15
5.40
0.44
Increase
0.47
2LZM
N55G
78.55
41.90
2.00
-0.50
Decrease
-1.05
2LZM
N55G
78.55
64.70
6.50
-0.60
Decrease
-0.69
2LZM
N68A
52.87
47.80
2.50
-0.05
Decrease
0.01
2LZM
Q69P
50.06
38.50
2.00
-3.30
Decrease
-0.80
2LZM
Q69P
50.06
63.20
6.50
-2.90
Decrease
-0.95
2LZM
R14K
51.53
65.15
5.40
-0.03
Decrease
-1.34
2LZM
R80K
79.30
65.15
5.40
-0.17
Decrease
-0.38
2LZM
R96H
30.74
65.50
6.00
-2.82
Decrease
-1.12
2LZM
R96H
30.74
70.00
6.50
-2.80
Decrease
-1.09
2LZM
S38D
44.45
40.90
2.00
-0.10
Increase
0.77
2LZM
S38D
44.45
53.42
3.00
0.22
Increase
0.78
2LZM
S38D
44.45
66.10
6.90
0.60
Increase
0.62
2LZM
S38D
44.45
66.51
5.40
0.60
Increase
0.70
2LZM
S38N
44.45
39.50
2.00
-0.10
Increase
-0.21
2LZM
S38N
44.45
62.40
6.70
0.00
Increase
-0.20
2LZM
S44A
57.85
47.80
2.50
-0.44
Increase
-0.33
2LZM
S44A
57.85
51.65
3.00
0.44
Increase
-0.32
2LZM
S44A
57.85
51.68
3.01
0.43
Increase
-0.32
2LZM
S44A
57.85
62.20
6.70
0.34
Increase
-0.44
2LZM
S44C
57.85
51.68
3.01
-0.11
Increase
-0.08
2LZM
S44D
57.85
51.68
3.01
-0.11
Increase
-0.11
2LZM
S44E
57.85
51.68
3.01
0.00
Increase
0.09
2LZM
S44F
57.85
51.68
3.01
0.06
Increase
0.17
2LZM
S44G
57.85
51.68
3.01
-0.53
Increase
-0.43
2LZM
S44H
57.85
51.68
3.01
0.04
Increase
-0.66
2LZM
S44I
57.85
51.68
3.01
0.31
Increase
0.16
2LZM
S44K
57.85
51.68
3.01
0.20
Increase
-0.71
2LZM
S44L
57.85
51.68
3.01
0.39
Increase
0.33
2LZM
S44M
57.85
51.68
3.01
0.33
Increase
0.40
2LZM
S44N
57.85
51.68
3.01
-0.14
Increase
-0.12
2LZM
S44P
57.85
51.68
3.01
-3.03
Increase
-0.07
2LZM
S44Q
57.85
51.68
3.01
0.27
Increase
0.10
2LZM
S44R
57.85
51.68
3.01
0.24
Increase
0.00
2LZM
S44T
57.85
51.68
3.01
0.01
Increase
0.92
2LZM
S44V
57.85
51.68
3.01
0.10
Increase
0.40
2LZM
S44W
57.85
51.68
3.01
0.05
Increase
0.04
2LZM
S44Y
57.85
51.68
3.01
0.19
Increase
-0.82
2LZM
S90H
32.42
28.50
2.00
-1.00
Decrease
-0.60
2LZM
S90H
32.42
63.00
6.50
-1.10
Decrease
-0.46
2LZM
S90H
32.42
65.40
5.50
-1.10
Decrease
-0.42
2LZM
T26S
4.61
65.15
5.40
0.57
Decrease
-0.75
2LZM
T59A
51.77
41.00
2.00
-2.80
Decrease
-1.13
2LZM
T59A
51.77
63.00
6.50
-1.50
Decrease
-0.96
2LZM
T59D
51.77
41.00
2.00
-0.90
Decrease
-1.23
2LZM
T59D
51.77
63.00
6.50
-1.20
Decrease
-0.68
2LZM
T59G
51.77
41.00
2.00
-2.20
Decrease
-1.85
2LZM
T59G
51.77
63.00
6.50
-1.60
Decrease
-1.77
2LZM
T59N
51.77
41.00
2.00
-0.60
Decrease
-1.83
2LZM
T59N
51.77
63.00
6.50
-1.10
Decrease
-1.57
2LZM
T59S
51.77
41.00
2.00
-0.70
Decrease
-0.28
2LZM
T59S
51.77
63.00
6.50
-0.20
Decrease
0.37
2LZM
T59V
51.77
41.00
2.00
-2.80
Decrease
-0.68
2LZM
T59V
51.77
63.00
6.50
-1.50
Decrease
-0.48
2LZM
V71A
4.29
51.65
3.00
-1.50
Decrease
-1.06
2LZM
V75T
24.01
51.55
3.00
-1.30
Decrease
-1.64
2LZM
V87A
2.21
51.65
3.00
-1.70
Decrease
-1.65
2LZM
V87T
2.21
51.55
3.00
-1.60
Decrease
-1.61
2LZM
V94A
20.95
51.65
3.00
-1.80
Decrease
-1.38
2LZM
A129L
0.00
65.30
5.40
-1.30
Decrease
0.38
2LZM
A129M
0.00
65.30
5.40
-1.90
Decrease
-0.50
2LZM
A129V
0.00
41.40
1.99
-0.80
Increase
-0.71
2LZM
A129V
0.00
52.10
2.80
-0.70
Increase
-0.63
2LZM
A130S
6.53
51.55
3.00
-1.00
Decrease
-1.12
2LZM
A134S
26.32
51.55
3.00
-0.10
Decrease
-0.72
2LZM
A146T
0.00
47.00
3.00
-2.29
Decrease
-1.63
2LZM
A146T
0.00
70.00
6.50
-1.50
Decrease
-1.69
2LZM
A160T
14.88
65.50
6.00
-1.65
Decrease
-0.58
2LZM
E108V
27.93
51.70
3.00
1.20
Increase
0.26
2LZM
E108V
27.93
65.20
5.40
0.70
Increase
0.50
2LZM
E128A
49.63
40.75
2.02
0.16
Decrease
0.32
2LZM
E128A
49.63
40.80
2.00
0.16
Decrease
0.32
2LZM
E128K
49.63
47.00
3.00
-1.16
Decrease
-1.09
2LZM
F104A
15.55
51.65
3.00
-3.10
Decrease
-1.69
2LZM
F153A
0.05
51.76
3.01
-3.50
Decrease
-2.45
2LZM
F153A
0.05
51.80
3.01
-3.50
Decrease
-2.45
2LZM
F153A
0.05
64.88
5.70
-3.80
Decrease
-2.30
2LZM
F153A
0.05
65.30
5.40
-3.40
Decrease
-2.27
2LZM
F153I
0.05
51.76
3.01
-0.50
Decrease
-0.92
2LZM
F153I
0.05
64.88
5.70
-0.20
Decrease
-0.81
2LZM
F153L
0.05
51.76
3.01
0.20
Decrease
-0.94
2LZM
F153L
0.05
64.88
5.70
0.30
Decrease
-0.93
2LZM
F153L
0.05
65.15
5.40
0.35
Decrease
-0.91
2LZM
F153M
0.05
51.76
3.01
-0.80
Decrease
-1.36
2LZM
F153M
0.05
64.88
5.70
-0.60
Decrease
-1.30
2LZM
F153M
0.05
65.30
5.42
-0.60
Decrease
-1.28
2LZM
F153V
0.05
51.76
3.01
-1.80
Decrease
-1.34
2LZM
F153V
0.05
64.88
5.70
-1.80
Decrease
-1.21
2LZM
G113A
73.82
38.80
2.00
0.50
Decrease
-0.17
2LZM
G113A
73.82
41.90
2.00
0.10
Decrease
-0.11
2LZM
G113A
73.82
46.20
2.50
0.54
Decrease
-0.01
2LZM
G113A
73.82
53.60
3.00
0.54
Decrease
0.12
2LZM
G113A
73.82
64.70
6.50
0.30
Decrease
0.24
2LZM
G113E
73.82
65.15
5.40
0.30
Increase
1.15
2LZM
G156D
22.87
41.90
2.00
-1.40
Decrease
-1.85
2LZM
G156D
22.87
64.70
6.50
-2.30
Decrease
-1.68
2LZM
I100A
4.86
51.65
3.00
-3.40
Decrease
-1.83
2LZM
I100M
4.86
65.30
5.42
-1.60
Decrease
-1.92
2LZM
K124G
50.51
41.90
2.00
0.00
Decrease
-0.13
2LZM
K124G
50.51
64.70
6.50
-0.10
Decrease
-0.12
2LZM
K135E
71.85
25.00
5.30
-1.00
Increase
0.60
2LZM
K135E
71.85
50.90
2.80
-0.20
Increase
0.80
2LZM
K135E
71.85
66.70
5.30
-1.00
Increase
0.83
2LZM
K147E
43.90
25.00
5.30
-0.70
Decrease
-0.71
2LZM
K147E
43.90
50.90
2.80
0.10
Decrease
-0.39
2LZM
K147E
43.90
66.70
5.30
-0.70
Decrease
-0.37
2LZM
L118A
5.30
51.65
3.01
-3.50
Decrease
-2.74
2LZM
L118A
5.30
51.80
3.01
-3.50
Decrease
-2.74
2LZM
L118M
5.30
65.30
5.42
-0.70
Decrease
-0.70
2LZM
L121A
0.11
51.65
3.01
-2.70
Decrease
-4.58
2LZM
L121A
0.11
51.80
3.01
-2.70
Decrease
-4.58
2LZM
L121A
0.11
65.30
5.40
-2.30
Decrease
-4.32
2LZM
L121M
0.11
65.30
5.42
-0.80
Decrease
-0.50
2LZM
L133A
0.44
40.75
2.02
-4.19
Decrease
-1.96
2LZM
L133A
0.44
51.80
3.01
-4.30
Decrease
-1.72
2LZM
L133D
0.44
51.60
3.00
-4.90
Decrease
-2.56
2LZM
L133D
0.44
61.90
6.50
-5.70
Decrease
-2.48
2LZM
L133D
0.44
64.60
4.40
-5.50
Decrease
-2.46
2LZM
L133F
0.44
41.40
1.99
-0.20
Decrease
-1.39
2LZM
L133F
0.44
52.10
2.86
-0.30
Decrease
-1.30
2LZM
L133M
0.44
65.30
5.42
-0.40
Decrease
-1.99
2LZM
M102K
0.35
47.90
10.40
-2.20
Decrease
-4.56
2LZM
M102K
0.35
51.60
3.00
-8.90
Decrease
-4.94
2LZM
M102K
0.35
65.30
5.30
-6.90
Decrease
-4.83
2LZM
M102L
0.35
51.76
3.01
-0.74
Decrease
-1.48
2LZM
M102L
0.35
64.89
5.70
-0.82
Decrease
-1.37
2LZM
M106A
28.04
51.65
3.00
-2.30
Decrease
-1.03
2LZM
M106K
28.04
47.00
3.00
-3.40
Decrease
-3.30
2LZM
M106L
28.04
47.00
3.00
0.50
Decrease
0.31
2LZM
M120A
16.49
51.65
3.01
-0.20
Decrease
-1.10
2LZM
M120K
16.49
47.00
3.00
-1.60
Decrease
-1.25
2LZM
M120L
16.49
47.00
3.00
0.50
Decrease
0.24
2LZM
N101A
0.14
59.00
5.40
-1.50
Decrease
-1.36
2LZM
N116A
52.39
51.65
3.01
0.17
Increase
0.08
2LZM
N116D
52.39
40.90
2.00
-0.10
Increase
-0.73
2LZM
N116D
52.39
53.42
3.00
0.34
Increase
-0.62
2LZM
N116D
52.39
66.10
5.70
0.60
Increase
-0.63
2LZM
N116D
52.39
66.51
5.40
0.60
Increase
-0.61
2LZM
N132F
28.01
66.48
5.40
1.30
Increase
0.98
2LZM
N132I
28.01
66.48
5.40
1.20
Increase
1.49
2LZM
N132M
28.01
66.48
5.40
1.50
Increase
0.77
2LZM
N144D
66.87
40.90
2.00
-0.10
Increase
-0.04
2LZM
N144D
66.87
53.42
3.00
0.40
Increase
0.22
2LZM
N144D
66.87
66.10
6.90
0.50
Increase
0.51
2LZM
N144D
66.87
66.51
5.40
0.41
Increase
0.49
2LZM
N144E
66.87
40.40
2.00
0.20
Increase
0.35
2LZM
N144E
66.87
64.50
6.50
0.50
Increase
0.69
2LZM
N144E
66.87
66.70
5.50
0.50
Increase
0.72
2LZM
N144H
66.87
39.50
2.00
-0.60
Decrease
-0.81
2LZM
N144H
66.87
62.40
6.70
0.30
Decrease
-0.29
2LZM
N163D
80.46
65.15
5.40
-0.21
Increase
0.68
2LZM
Q105A
32.53
42.00
2.10
-0.90
Decrease
-1.51
2LZM
Q105A
32.53
66.30
5.80
-0.60
Decrease
-1.13
2LZM
Q105E
32.53
42.00
2.10
-0.50
Decrease
-1.07
2LZM
Q105E
32.53
66.30
5.80
-1.10
Decrease
-1.05
2LZM
Q105G
32.53
42.00
2.10
-1.70
Decrease
-1.77
2LZM
Q105G
32.53
66.30
5.80
-1.50
Decrease
-1.65
2LZM
Q105M
32.53
59.00
5.40
-1.20
Decrease
0.83
2LZM
Q122A
42.44
51.65
3.01
-0.24
Decrease
-0.25
2LZM
Q123A
51.79
51.65
3.01
-0.22
Increase
0.29
2LZM
Q123E
51.51
40.40
2.00
0.30
Decrease
0.57
2LZM
Q123E
51.51
64.50
6.50
0.40
Decrease
0.39
2LZM
Q123E
51.51
66.70
5.50
0.10
Decrease
0.45
2LZM
R119A
50.26
51.65
3.01
-0.18
Decrease
0.04
2LZM
R119E
50.26
50.90
2.80
-0.20
Increase
0.69
2LZM
R119E
50.26
66.70
5.30
-0.04
Increase
0.64
2LZM
R119H
50.26
65.15
5.40
-0.29
Decrease
-0.96
2LZM
R119M
50.22
40.90
2.00
-0.30
Decrease
-0.09
2LZM
R119M
50.22
66.10
5.70
0.10
Decrease
-0.02
2LZM
R154E
34.63
50.90
2.80
0.20
Decrease
-0.56
2LZM
R154E
34.63
66.70
5.30
-1.10
Decrease
-0.50
2LZM
S117A
0.85
51.65
3.01
1.27
Decrease
0.27
2LZM
S117F
0.85
51.70
3.00
1.40
Increase
1.45
2LZM
S117F
0.85
65.09
5.40
1.10
Increase
1.34
2LZM
S117F
0.85
66.48
5.40
1.10
Increase
1.34
2LZM
S117I
0.85
66.48
5.40
1.70
Increase
1.81
2LZM
S117V
0.85
66.48
5.40
2.00
Increase
1.68
2LZM
T109D
84.21
39.50
2.00
-0.30
Increase
-0.01
2LZM
T109D
84.21
62.40
6.70
0.60
Increase
0.13
2LZM
T109N
84.21
39.50
2.00
0.00
Decrease
0.19
2LZM
T109N
84.21
62.40
6.70
0.10
Increase
0.43
2LZM
T115A
62.80
51.65
3.01
-0.14
Decrease
-0.67
2LZM
T115E
62.73
40.40
2.00
-0.50
Increase
-0.47
2LZM
T115E
62.73
40.90
2.00
-0.50
Increase
-0.47
2LZM
T115E
62.73
52.60
3.00
-0.20
Increase
-0.40
2LZM
T115E
62.73
63.60
4.00
-0.10
Increase
-0.35
2LZM
T115E
62.73
64.60
6.50
0.30
Increase
-0.32
2LZM
T115E
62.73
66.10
6.50
0.30
Increase
-0.32
2LZM
T115E
62.73
66.70
5.50
0.00
Increase
-0.32
2LZM
T151S
22.71
65.15
5.40
0.39
Decrease
-0.62
2LZM
T152A
0.00
59.00
5.40
-1.50
Decrease
-1.61
2LZM
T152C
0.00
59.00
5.40
-0.50
Decrease
-0.62
2LZM
T152I
0.00
59.00
5.40
-0.40
Decrease
-0.46
2LZM
T152S
0.00
40.00
3.00
-2.60
Decrease
-1.08
2LZM
T152S
0.00
59.00
5.40
-2.00
Decrease
-0.67
2LZM
T152V
0.00
59.00
5.40
0.20
Decrease
-1.57
2LZM
T157A
41.82
38.80
2.00
-1.10
Decrease
-1.22
2LZM
T157A
41.82
42.00
2.00
-1.40
Decrease
-1.16
2LZM
T157A
41.82
46.20
2.50
-0.90
Decrease
-1.07
2LZM
T157A
41.82
53.60
3.00
-0.50
Decrease
-0.93
2LZM
T157C
41.82
42.00
2.00
-1.30
Decrease
-0.53
2LZM
T157D
41.82
42.00
2.00
-1.10
Decrease
-1.47
2LZM
T157E
41.82
38.80
2.00
-1.50
Decrease
-1.02
2LZM
T157E
41.82
42.00
2.00
-1.50
Decrease
-0.99
2LZM
T157E
41.82
46.20
2.50
-1.30
Decrease
-0.94
2LZM
T157E
41.82
53.60
3.00
-0.80
Decrease
-0.85
2LZM
T157F
41.82
42.00
2.00
-2.40
Decrease
0.14
2LZM
T157G
41.82
42.00
2.00
-1.10
Decrease
-2.90
2LZM
T157H
41.82
42.00
2.00
-2.10
Decrease
-2.18
2LZM
T157I
41.82
38.80
2.00
-2.10
Decrease
-0.79
2LZM
T157I
41.82
42.00
2.00
-2.90
Decrease
-0.73
2LZM
T157I
41.82
46.20
2.50
-1.90
Decrease
-0.63
2LZM
T157I
41.82
53.60
3.00
-1.50
Decrease
-0.47
2LZM
T157I
41.82
62.80
4.00
-2.10
Decrease
-0.26
2LZM
T157I
41.82
64.50
6.00
-1.20
Decrease
-0.09
2LZM
T157L
41.82
38.80
2.00
-1.70
Decrease
-1.30
2LZM
T157L
41.82
42.00
2.00
-1.30
Decrease
-1.23
2LZM
T157L
41.82
46.20
2.50
-1.70
Decrease
-1.13
2LZM
T157L
41.82
53.60
3.00
-1.70
Decrease
-0.98
2LZM
T157N
41.82
38.80
2.00
-1.00
Decrease
-0.91
2LZM
T157N
41.82
42.00
2.00
-0.45
Decrease
-0.87
2LZM
T157N
41.82
46.20
2.50
-1.10
Decrease
-0.81
2LZM
T157N
41.82
53.60
3.00
-1.20
Decrease
-0.72
2LZM
T157R
41.82
38.80
2.00
-1.10
Decrease
-0.97
2LZM
T157R
41.82
42.00
2.00
-1.30
Decrease
-0.92
2LZM
T157R
41.82
46.20
2.50
-0.60
Decrease
-0.84
2LZM
T157R
41.82
53.60
3.00
0.30
Decrease
-0.71
2LZM
T157S
41.82
42.00
2.00
-0.66
Decrease
-1.16
2LZM
T157V
41.82
38.80
2.00
-1.70
Decrease
-1.50
2LZM
T157V
41.82
42.00
2.00
-1.60
Decrease
-1.43
2LZM
T157V
41.82
46.20
2.50
-1.60
Decrease
-1.32
2LZM
T157V
41.82
53.60
3.00
-1.20
Decrease
-1.15
2LZM
V103A
4.68
51.65
3.00
-2.20
Decrease
-2.43
2LZM
V103M
4.68
65.30
5.42
-1.20
Decrease
-1.53
2LZM
V111A
0.00
51.65
3.00
-1.30
Decrease
-1.74
2LZM
V111F
0.00
51.76
3.01
-1.43
Decrease
-2.15
2LZM
V111F
0.00
64.89
5.70
-1.69
Decrease
-2.25
2LZM
V111I
0.00
51.76
3.01
-0.69
Decrease
0.16
2LZM
V111I
0.00
64.89
5.70
-0.85
Decrease
0.21
2LZM
V131A
64.48
40.75
2.02
0.27
Decrease
-0.54
2LZM
V131A
64.48
40.80
2.00
0.26
Decrease
-0.54
2LZM
V131A
64.48
41.47
2.03
0.15
Decrease
-0.53
2LZM
V131A
64.48
51.10
2.83
0.30
Decrease
-0.42
2LZM
V131A
64.48
53.08
3.01
0.26
Decrease
-0.40
2LZM
V131A
64.48
53.42
3.00
0.33
Decrease
-0.40
2LZM
V131A
64.48
66.51
5.40
0.39
Decrease
-0.31
2LZM
V131D
64.48
53.08
3.01
0.08
Decrease
-0.75
2LZM
V131E
64.48
53.08
3.01
0.20
Decrease
-0.35
2LZM
V131G
64.48
53.08
3.01
-0.68
Decrease
-0.50
2LZM
V131I
64.48
53.08
3.01
0.16
Increase
0.97
2LZM
V131L
64.48
53.08
3.01
0.09
Increase
0.51
2LZM
V131M
64.48
53.08
3.01
0.12
Increase
0.42
2LZM
V131S
64.48
53.08
3.01
-0.05
Decrease
-0.85
2LZM
V131T
64.48
41.47
2.03
-0.11
Increase
0.54
2LZM
V131T
64.48
51.10
2.83
-0.05
Increase
0.64
2LZM
V131T
64.48
53.08
3.01
-0.12
Increase
0.65
2LZM
V149A
0.07
51.65
3.00
-3.20
Decrease
-3.24
2LZM
V149A
0.07
59.00
5.40
-3.10
Decrease
-3.25
2LZM
V149C
0.07
40.00
3.00
-2.20
Decrease
-2.08
2LZM
V149C
0.07
59.00
5.40
-2.00
Decrease
-2.07
2LZM
V149G
0.07
59.00
5.40
-4.90
Decrease
-5.04
2LZM
V149I
0.07
59.00
5.40
-0.10
Decrease
-0.91
2LZM
V149S
0.07
59.00
5.40
-4.40
Decrease
-3.10
2LZM
V149T
0.07
51.55
3.00
-2.80
Decrease
-1.98
2LZM
V149T
0.07
59.00
5.40
-3.00
Decrease
-2.02
2RN2
A24V
0.00
50.10
3.00
0.73
Decrease
-0.37
2RN2
A24V
0.00
52.70
5.50
0.88
Decrease
-0.26
2RN2
A52C
0.27
53.00
3.20
0.80
Decrease
-1.09
2RN2
A52D
0.27
53.00
3.20
-1.90
Decrease
-1.97
2RN2
A52E
0.27
53.00
3.20
-1.50
Decrease
-0.93
2RN2
A52F
0.27
53.00
3.20
0.50
Decrease
-0.25
2RN2
A52G
0.27
53.00
3.20
-2.70
Decrease
-1.72
2RN2
A52H
0.27
53.00
3.20
-3.60
Decrease
-1.55
2RN2
A52I
0.27
53.00
3.20
1.90
Decrease
0.02
2RN2
A52K
0.27
53.00
3.20
-5.90
Decrease
-2.07
2RN2
A52L
0.27
53.00
3.20
1.30
Decrease
-0.02
2RN2
A52M
0.27
53.00
3.20
0.50
Decrease
0.47
2RN2
A52N
0.27
53.00
3.20
-1.80
Decrease
-1.84
2RN2
A52P
0.27
53.00
3.20
-1.60
Decrease
-2.00
2RN2
A52Q
0.27
53.00
3.20
-1.20
Decrease
-1.25
2RN2
A52S
0.27
53.00
3.20
-1.80
Decrease
-0.35
2RN2
A52T
0.27
53.00
3.20
-0.80
Decrease
-0.76
2RN2
A52V
0.27
50.10
3.00
1.70
Decrease
-0.41
2RN2
A52V
0.27
53.00
3.20
1.70
Decrease
-0.39
2RN2
A52Y
0.27
53.00
3.20
-2.30
Decrease
-1.43
2RN2
D10A
12.77
47.00
9.00
4.00
Increase
1.03
2RN2
D10A
12.77
50.00
3.00
2.40
Increase
0.16
2RN2
D10E
12.77
47.00
9.00
1.00
Increase
1.84
2RN2
D10E
12.77
50.00
3.00
1.10
Increase
0.73
2RN2
D10H
12.77
47.00
9.00
2.40
Increase
2.21
2RN2
D10H
12.77
50.00
3.00
0.40
Increase
0.91
2RN2
D10N
12.77
47.00
9.00
2.00
Increase
1.44
2RN2
D10N
12.77
50.00
3.00
-0.70
Increase
0.40
2RN2
D10S
12.77
47.00
9.00
2.70
Increase
1.59
2RN2
D10S
12.77
50.00
3.00
0.70
Increase
0.40
2RN2
D70A
37.54
47.00
9.00
1.10
Increase
-0.70
2RN2
D70A
37.54
50.00
3.00
-0.10
Increase
-0.67
2RN2
D70E
37.54
47.00
9.00
0.10
Increase
0.03
2RN2
D70E
37.54
50.00
3.00
0.50
Increase
-0.03
2RN2
D70N
37.54
47.00
9.00
1.60
Increase
-0.06
2RN2
D70N
37.54
50.00
3.00
-0.30
Increase
-0.07
2RN2
D94E
69.12
49.80
3.00
-0.40
Increase
0.09
2RN2
D94E
69.12
49.80
5.50
-0.40
Increase
-0.13
2RN2
E48A
10.88
47.00
9.00
-0.30
Decrease
-0.61
2RN2
E48A
10.88
50.00
3.00
-0.10
Decrease
-0.63
2RN2
E48D
10.88
47.00
9.00
-0.20
Decrease
-0.76
2RN2
E48D
10.88
50.00
3.00
0.20
Decrease
-0.70
2RN2
E48Q
10.88
47.00
9.00
0.30
Decrease
0.29
2RN2
E48Q
10.88
50.00
3.00
-0.10
Decrease
0.16
2RN2
G23A
0.00
50.10
3.00
0.70
Decrease
-1.39
2RN2
G23A
0.00
50.90
3.00
0.70
Decrease
-1.39
2RN2
G23A
0.00
52.50
5.50
0.50
Decrease
-1.13
2RN2
G23A
0.00
52.70
5.50
0.50
Decrease
-1.13
2RN2
G77A
0.00
49.80
3.00
-0.90
Decrease
-0.95
2RN2
H62D
72.46
50.10
3.00
0.67
Increase
-0.74
2RN2
H62D
72.46
52.70
5.50
-0.17
Increase
-0.78
2RN2
H62P
72.46
49.80
3.00
1.00
Increase
-0.40
2RN2
H62P
72.46
50.10
3.00
1.00
Increase
-0.39
2RN2
H62P
72.46
50.90
3.00
1.00
Increase
-0.39
2RN2
H62P
72.46
52.00
5.50
1.10
Increase
-0.47
2RN2
H62P
72.46
52.50
5.50
1.10
Increase
-0.47
2RN2
H62P
72.46
52.70
5.50
1.10
Increase
-0.47
2RN2
H62R
72.46
50.10
3.00
-0.03
Increase
0.46
2RN2
H62R
72.46
52.70
5.50
0.36
Increase
0.41
2RN2
K91R
39.13
49.80
3.00
0.20
Increase
0.05
2RN2
K91R
39.13
49.80
5.50
0.00
Increase
0.02
2RN2
K95A
66.60
49.80
3.00
0.10
Increase
1.17
2RN2
K95A
66.60
49.80
5.50
0.10
Increase
1.08
2RN2
K95G
66.60
49.80
3.00
1.70
Increase
-0.77
2RN2
K95G
66.60
49.80
5.50
1.90
Increase
-0.89
2RN2
K95N
66.60
49.80
3.00
0.90
Increase
0.59
2RN2
K95N
66.60
49.80
5.50
0.90
Increase
0.45
2RN2
K95N
66.60
50.10
3.00
0.88
Increase
0.59
2RN2
K95N
66.60
52.70
5.50
0.88
Increase
0.47
2RN2
Q76L
32.08
50.10
3.00
0.24
Increase
0.65
2RN2
Q80L
59.63
50.10
3.00
0.30
Increase
0.33
2RN2
R41C
51.18
50.10
3.00
0.12
Increase
0.58
2RN2
R41C
51.18
52.70
5.50
0.44
Increase
0.63
2RN2
S68A
0.85
49.80
3.00
-0.50
Decrease
-0.35
2RN2
S68G
0.85
49.80
3.00
-2.40
Decrease
-0.79
2RN2
S68L
0.85
49.80
3.00
-0.50
Increase
-0.08
2RN2
S68T
0.85
49.80
3.00
-0.20
Increase
-0.36
2RN2
S68V
0.85
49.80
3.00
0.60
Increase
-0.54
2RN2
V74A
0.39
49.80
3.00
-2.20
Increase
-0.95
2RN2
V74A
0.39
52.00
5.50
-3.40
Increase
-1.00
2RN2
V74I
0.39
49.80
3.00
0.70
Increase
-0.27
2RN2
V74I
0.39
52.00
5.50
0.60
Increase
-0.31
2RN2
V74L
0.39
49.80
3.00
1.10
Decrease
-0.85
2RN2
V74L
0.39
50.90
3.00
1.10
Decrease
-0.84
2RN2
V74L
0.39
52.00
5.50
0.90
Decrease
-0.87
2RN2
V74L
0.39
52.50
5.50
0.90
Decrease
-0.87
2RN2
A125T
62.98
49.80
3.00
0.10
Decrease
0.51
2RN2
A125T
62.98
52.00
5.50
0.00
Decrease
0.45
2RN2
D134A
34.70
47.00
9.00
2.00
Increase
2.46
2RN2
D134A
34.70
50.00
3.00
0.80
Increase
1.41
2RN2
D134A
34.70
50.00
3.00
0.89
Increase
1.41
2RN2
D134A
34.70
53.10
5.50
1.51
Increase
1.96
2RN2
D134E
34.70
50.00
3.00
0.72
Increase
0.41
2RN2
D134E
34.70
53.10
5.50
0.86
Increase
0.78
2RN2
D134H
34.70
50.00
3.00
0.53
Increase
0.33
2RN2
D134H
34.70
50.90
3.00
0.50
Increase
0.33
2RN2
D134H
34.70
52.50
5.50
1.90
Increase
1.02
2RN2
D134H
34.70
53.10
5.50
1.94
Increase
1.03
2RN2
D134I
34.70
50.00
3.00
0.69
Increase
0.19
2RN2
D134I
34.70
53.10
5.50
1.27
Increase
0.69
2RN2
D134L
34.70
50.00
3.00
1.15
Increase
0.62
2RN2
D134L
34.70
53.10
5.50
1.51
Increase
1.10
2RN2
D134N
34.70
47.00
9.00
1.80
Increase
1.76
2RN2
D134N
34.70
50.00
3.00
-0.10
Increase
0.67
2RN2
D134N
34.70
50.00
3.00
-0.10
Increase
0.67
2RN2
D134N
34.70
53.10
5.50
0.89
Increase
1.19
2RN2
D134Q
34.70
50.00
3.00
0.48
Increase
0.56
2RN2
D134Q
34.70
53.10
5.50
1.32
Increase
1.11
2RN2
D134S
34.70
50.00
3.00
0.26
Increase
0.84
2RN2
D134S
34.70
53.10
5.50
1.08
Increase
1.55
2RN2
D134T
34.70
50.00
3.00
0.12
Increase
0.46
2RN2
D134T
34.70
53.10
5.50
1.08
Increase
0.91
2RN2
D134V
34.70
50.00
3.00
0.31
Increase
0.31
2RN2
D134V
34.70
53.10
5.50
1.12
Increase
0.82
2RN2
E119V
32.63
50.10
3.00
0.09
Increase
0.10
2RN2
E119V
32.63
52.70
5.50
0.74
Increase
-0.05
2RN2
E135K
60.62
50.10
3.00
-1.10
Decrease
-1.13
2RN2
E135K
60.62
52.70
5.50
-0.22
Decrease
-0.91
2RN2
K117R
57.37
50.10
3.00
-0.06
Increase
-0.27
2RN2
K117R
57.37
52.70
5.50
0.03
Increase
-0.32
2RN2
Q113P
54.48
49.80
3.00
-0.20
Decrease
-1.43
2RN2
Q113P
54.48
52.00
5.50
-0.60
Decrease
-1.39
2TRX
L78K
0.16
85.32
7.00
-3.90
Decrease
-4.31
2TRX
L78R
0.16
85.32
7.00
-4.00
Decrease
-2.05
3BLS
Y150F
8.66
54.60
6.80
-0.70
Decrease
0.25
3MBP
V8G
26.28
25.00
7.60
-1.10
Decrease
-2.44
3MBP
D55N
32.41
25.00
7.60
0.00
Decrease
-1.45
3MBP
G19C
23.13
25.00
7.60
-2.30
Decrease
-1.23
3MBP
A276G
48.91
25.00
7.60
-1.50
Decrease
-1.13
3MBP
T345I
42.11
25.00
7.60
0.70
Decrease
-0.51
3MBP
Y283D
26.44
25.00
7.60
-3.20
Decrease
-1.22
3SSI
M73A
105.60
53.36
3.20
0.54
Decrease
-0.65
3SSI
M73A
105.60
53.36
7.00
0.55
Decrease
-0.80
3SSI
M73A
105.60
53.36
9.50
0.13
Decrease
-0.90
3SSI
M73D
105.60
53.36
3.20
1.08
Decrease
-0.31
3SSI
M73D
105.60
53.36
7.00
1.60
Decrease
-0.53
3SSI
M73D
105.60
53.36
9.50
1.25
Decrease
-0.69
3SSI
M73E
105.60
53.36
3.20
0.35
Decrease
0.36
3SSI
M73E
105.60
53.36
7.00
1.05
Decrease
0.10
3SSI
M73E
105.60
53.36
9.50
0.56
Decrease
-0.08
3SSI
M73G
105.60
53.36
3.20
-0.21
Increase
-0.85
3SSI
M73G
105.60
53.36
7.00
-0.06
Decrease
-1.18
3SSI
M73G
105.60
53.36
9.50
-0.49
Decrease
-1.37
3SSI
M73I
105.60
53.36
3.20
-0.73
Increase
0.71
3SSI
M73I
105.60
53.36
7.00
-0.94
Increase
0.61
3SSI
M73I
105.60
53.36
9.50
-1.28
Increase
0.52
3SSI
M73K
105.60
53.36
3.20
1.27
Decrease
-0.16
3SSI
M73K
105.60
53.36
7.00
0.35
Decrease
-0.18
3SSI
M73K
105.60
53.36
9.50
0.05
Decrease
-0.21
3SSI
M73L
105.60
53.36
3.20
-0.13
Increase
-0.16
3SSI
M73L
105.60
53.36
7.00
-0.25
Increase
-0.28
3SSI
M73L
105.60
53.36
9.50
-0.55
Increase
-0.37
3SSI
M73V
105.60
53.36
3.20
-0.46
Increase
1.00
3SSI
M73V
105.60
53.36
7.00
-0.66
Increase
0.91
3SSI
M73V
105.60
53.36
9.50
-0.95
Increase
0.81
3SSI
V13A
36.56
82.21
7.00
-6.78
Decrease
-3.22
3SSI
V13A
36.56
82.21
9.50
-6.93
Decrease
-3.31
3SSI
V13F
36.56
82.21
7.00
-5.69
Decrease
-4.56
3SSI
V13F
36.56
82.21
9.50
-5.33
Decrease
-4.63
3SSI
V13G
36.56
82.21
7.00
-10.30
Decrease
-6.13
3SSI
V13G
36.56
82.21
9.50
-9.31
Decrease
-6.24
3SSI
V13I
36.56
82.21
7.00
-0.84
Decrease
-4.25
3SSI
V13I
36.56
82.21
9.50
-0.94
Decrease
-4.32
3SSI
V13L
36.56
82.21
7.00
-2.21
Decrease
-4.47
3SSI
V13L
36.56
82.21
9.50
-2.52
Decrease
-4.59
3SSI
V13M
36.56
82.21
7.00
-5.92
Decrease
-3.92
3SSI
V13M
36.56
82.21
9.50
-5.43
Decrease
-3.95
3SSI
M103A
0.25
53.36
3.20
-1.35
Decrease
-3.60
3SSI
M103A
0.25
80.70
9.50
-2.80
Decrease
-4.02
3SSI
M103A
0.25
82.21
7.00
-2.32
Decrease
-3.84
3SSI
M103G
0.25
80.70
9.50
-7.10
Decrease
-4.79
3SSI
M103G
0.25
82.21
7.00
-6.82
Decrease
-4.66
3SSI
M103I
0.25
53.36
3.20
-2.01
Decrease
0.35
3SSI
M103I
0.25
80.70
9.50
-2.29
Decrease
-0.49
3SSI
M103I
0.25
82.21
7.00
-1.89
Decrease
-0.25
3SSI
M103L
0.25
53.36
3.20
0.77
Decrease
-1.73
3SSI
M103L
0.25
80.70
9.50
-0.29
Decrease
-2.30
3SSI
M103L
0.25
82.21
7.00
0.15
Decrease
-2.10
3SSI
M103V
0.25
53.36
3.20
-1.35
Decrease
0.11
3SSI
M103V
0.25
80.70
9.50
-2.22
Decrease
-0.58
3SSI
M103V
0.25
82.21
7.00
-1.84
Decrease
-0.37
451C
F7A
9.32
50.40
5.00
1.10
Decrease
-2.08
451C
E43Y
55.12
50.40
5.00
0.60
Increase
0.43
451C
F34Y
11.61
50.40
5.00
1.90
Decrease
-0.25
451C
Q37R
57.05
50.40
5.00
0.50
Increase
-0.10
451C
V13M
39.30
50.40
5.00
0.40
Decrease
0.22
451C
V78I
4.94
50.40
5.00
1.00
Increase
-0.25
451C
V78I
4.94
62.60
3.60
1.11
Increase
-0.11
4LYZ
F3Y
7.72
74.00
6.40
-0.45
Decrease
-0.94
4LYZ
A31I
0.00
74.00
6.40
1.40
Increase
0.24
4LYZ
A31L
0.00
74.00
6.40
1.80
Decrease
-0.21
4LYZ
A31V
0.00
74.00
6.40
1.20
Decrease
0.68
4LYZ
C94A
2.07
20.00
9.50
-4.78
Decrease
-2.09
4LYZ
F34Y
35.77
74.00
6.40
0.19
Decrease
0.15
4LYZ
G49A
28.21
65.60
2.70
-1.89
Decrease
-0.81
4LYZ
G49N
28.21
20.00
9.50
-0.96
Decrease
-1.94
4LYZ
G67A
94.28
65.60
2.70
-0.98
Decrease
-1.06
4LYZ
G71A
44.35
65.60
2.70
-0.38
Decrease
-1.22
4LYZ
H15L
24.30
74.00
6.40
0.76
Increase
1.12
4LYZ
I55A
0.43
74.00
6.40
-4.40
Decrease
-2.81
4LYZ
I55F
0.43
74.00
6.40
-2.46
Decrease
-2.95
4LYZ
I55L
0.43
74.00
6.40
-0.45
Decrease
-1.04
4LYZ
I55M
0.43
74.00
6.40
-2.27
Decrease
-2.06
4LYZ
I55T
0.43
74.00
6.40
-4.96
Decrease
-3.07
4LYZ
I55V
0.43
74.00
6.40
-0.91
Decrease
-2.03
4LYZ
K13D
37.19
20.00
9.50
-6.70
Decrease
-0.60
4LYZ
M12F
0.30
66.00
2.70
0.28
Decrease
-1.10
4LYZ
M12L
0.30
66.00
2.70
-0.57
Decrease
0.49
4LYZ
N19K
64.89
74.00
6.40
-1.06
Increase
0.64
4LYZ
N77H
84.15
74.00
6.40
-0.38
Increase
-0.35
4LYZ
P70N
91.12
20.00
9.50
-2.15
Decrease
-0.39
4LYZ
R21Q
62.31
74.00
6.40
-0.15
Decrease
-0.19
4LYZ
R68K
51.44
74.00
6.40
-0.04
Increase
-0.34
4LYZ
R73K
67.38
74.00
6.40
0.23
Decrease
-0.09
4LYZ
S91A
0.43
74.00
6.40
-0.15
Decrease
-1.52
4LYZ
S91D
0.43
74.00
6.40
-2.31
Decrease
-0.73
4LYZ
S91T
0.43
74.00
6.40
0.99
Decrease
-0.99
4LYZ
S91V
0.43
74.00
6.40
-0.08
Increase
-0.24
4LYZ
S91Y
0.43
74.00
6.40
-3.07
Decrease
-0.57
4LYZ
T40I
0.07
74.00
6.40
-2.20
Increase
0.11
4LYZ
T40S
0.07
74.00
6.40
-0.27
Decrease
-1.43
4LYZ
D101A
65.72
74.00
6.40
0.76
Increase
0.27
4LYZ
D101E
65.72
74.00
6.40
0.00
Increase
0.63
4LYZ
D101F
65.72
74.00
6.40
0.72
Increase
-0.02
4LYZ
D101G
65.72
74.00
6.40
0.45
Increase
0.01
4LYZ
D101G
65.72
74.00
6.40
0.45
Increase
0.01
4LYZ
D101K
65.72
74.00
6.40
0.19
Increase
-0.09
4LYZ
D101N
65.72
74.00
6.40
0.04
Increase
-0.09
4LYZ
D101Q
65.72
74.00
6.40
-0.08
Increase
0.71
4LYZ
D101R
65.72
74.00
6.40
0.27
Increase
0.88
4LYZ
D101S
65.72
74.00
6.40
0.87
Increase
0.50
4LYZ
G102A
81.45
65.60
2.70
0.02
Decrease
-1.49
4LYZ
G102R
81.45
74.00
6.40
0.38
Decrease
0.23
4LYZ
G102V
81.45
74.00
6.40
-0.04
Increase
-2.12
4LYZ
G117A
102.29
65.60
2.70
-1.46
Increase
0.19
4LYZ
M105T
0.00
20.00
9.50
-0.24
Decrease
-2.46
4LYZ
N103D
65.98
20.00
9.50
0.24
Increase
-1.03
4LYZ
Q121H
60.36
74.00
6.40
-0.45
Decrease
0.21
4LYZ
R114H
56.86
74.00
6.40
0.68
Decrease
0.18
5CRO
A36S
59.89
45.00
3.00
0.40
Decrease
-0.97
5CRO
Q16L
26.26
45.00
3.00
2.80
Increase
0.39
5CRO
Y26C
76.23
45.00
3.00
2.20
Increase
0.55
5CRO
Y26C
76.23
45.00
7.00
2.20
Increase
0.56
5CRO
Y26D
76.23
45.00
7.00
2.70
Increase
-0.07
5CRO
Y26F
76.23
45.00
7.00
0.40
Increase
0.90
5CRO
Y26H
76.23
45.00
7.00
1.90
Increase
-0.18
5CRO
Y26L
76.23
45.00
7.00
1.10
Increase
1.32
5CRO
Y26Q
76.23
45.00
7.00
1.40
Increase
0.57
5CRO
Y26V
76.23
45.00
7.00
0.90
Increase
0.27
5CRO
Y26W
76.23
45.00
7.00
-0.10
Increase
1.83

  • PDB: The PDB code of  the protein
  • Mutation: Wild type residue, residue position number and new residue
  • RSA(%): Relative solvent accessible area of the mutated residue
  • Temperature: in Celsius degrees
  • pH: -log[H+]
  • Exp-DDG: Experimental free energy change upon mutation. DG Unfold(Mutated)-DG Unfold(Wild-Type) in Kcal/mol
  • Pred-Stability: Predicted sign of the free enegy change
  • Pred-DDG: Predicted free energy change upon mutation in Kcal/mol