I-Mutant2.0

I-Mutant2.0 Help
Last Update 27/12/06


 

Data set used to train and test
the SVM based on  protein sequence

Protein
Mutation
Temperature
pH
Exp-DDG
Pred-Stability
Pred-DDG







1A23
H32L
30.00
7.00
4.60
Increase
2.88
1A23
H32L
30.00
7.00
5.30
Increase
2.88
1A23
H32S
30.00
7.00
3.60
Increase
1.37
1A23
H32S
30.00
7.00
5.20
Increase
1.37
1A23
H32Y
30.00
7.00
0.50
Increase
2.56
1A23
H32Y
30.00
7.00
6.80
Increase
2.56
1A23
H32Y
30.00
7.00
6.80
Increase
2.56
1AAR
K6E
25.00
5.00
0.53
Increase
0.06
1AAR
K6Q
25.00
5.00
0.26
Increase
-0.24
1AAR
F45W
25.00
5.00
0.32
Decrease
0.44
1AAR
H68E
25.00
5.00
0.77
Increase
0.52
1AAR
H68Q
25.00
5.00
0.55
Decrease
-1.70
1AAR
K27Q
25.00
5.00
-1.91
Decrease
-0.27
1AAR
K29N
25.00
5.00
-1.48
Decrease
-1.58
1AAR
K29Q
25.00
5.00
-1.67
Decrease
-0.57
1AAR
R42E
25.00
5.00
1.63
Decrease
-0.97
1AAR
R72Q
25.00
5.00
-0.33
Decrease
-0.22
1AG2
E200K
25.00
7.00
-0.14
Decrease
-0.76
1AG2
F198S
25.00
7.00
-2.46
Decrease
-1.34
1AG2
M129V
25.00
7.00
-0.33
Decrease
0.06
1AG2
Q217R
25.00
7.00
-2.13
Increase
0.98
1AG2
R208H
25.00
7.00
-1.44
Decrease
-1.12
1AG2
T183A
25.00
7.00
-4.62
Decrease
-1.28
1AG2
T190V
25.00
7.00
-0.17
Decrease
-1.44
1AG2
V180I
25.00
7.00
-0.50
Decrease
-1.00
1AG2
V210I
25.00
7.00
-0.26
Decrease
0.56
1AJ3
W22F
25.00
7.50
-1.11
Decrease
-1.26
1AKK
L94V
83.00
2.00
-1.20
Decrease
-1.37
1ANK
D84H
51.80
7.20
-1.40
Increase
0.53
1ANK
F86L
51.80
7.20
-0.80
Decrease
-1.91
1ANK
G85V
51.80
7.20
-2.40
Decrease
-0.92
1ANK
R88G
51.80
7.40
-0.20
Decrease
-0.02
1ARR
P8L
20.00
7.50
2.40
Decrease
-2.35
1ARR
P8L
25.00
7.50
2.49
Decrease
-2.31
1ARR
P8L
53.40
7.50
2.55
Decrease
-2.00
1AYF
C95S
37.00
8.50
0.96
Decrease
-0.66
1AYF
D76E
37.00
8.50
0.45
Increase
0.64
1AYF
H56Q
37.00
8.50
-1.67
Decrease
0.61
1AYF
H56R
37.00
8.50
-1.16
Decrease
0.24
1AYF
H56T
37.00
8.50
-1.19
Decrease
0.23
1AYF
T54A
37.00
8.50
-1.31
Decrease
-0.85
1AYF
T54S
37.00
8.50
0.05
Decrease
1.30
1AYF
Y82F
37.00
8.50
-0.01
Decrease
-0.24
1AYF
Y82L
37.00
8.50
-0.36
Decrease
0.02
1AYF
Y82S
37.00
8.50
-0.33
Decrease
-1.71
1AYF
Y82W
37.00
8.50
-0.21
Decrease
-0.05
1BNI
D8A
25.00
4.40
-0.69
Decrease
-0.77
1BNI
D8A
25.00
6.30
-0.90
Decrease
-0.89
1BNI
D8G
25.00
6.30
-1.17
Decrease
-1.18
1BNI
D8S
25.00
6.30
-0.97
Decrease
-0.98
1BNI
F7L
25.00
6.15
-4.60
Decrease
-1.38
1BNI
I4A
25.00
6.30
-1.40
Decrease
-3.41
1BNI
I4V
25.00
6.30
-0.60
Decrease
-0.87
1BNI
N5A
25.00
6.30
-1.90
Decrease
-0.60
1BNI
T6A
25.00
6.30
-2.10
Decrease
-0.91
1BNI
T6A
25.00
6.30
-2.23
Decrease
-0.91
1BNI
T6A
25.00
6.30
-2.53
Decrease
-0.91
1BNI
T6D
25.00
6.30
0.11
Decrease
-0.73
1BNI
T6E
25.00
6.30
-0.27
Decrease
-0.72
1BNI
T6G
25.00
6.30
-1.20
Decrease
-2.16
1BNI
T6G
25.00
6.30
-1.34
Decrease
-2.16
1BNI
T6H
25.00
4.40
-2.65
Decrease
-1.91
1BNI
T6H
25.00
8.90
-1.56
Decrease
-1.46
1BNI
T6N
25.00
6.30
-1.27
Decrease
-0.04
1BNI
T6P
25.00
6.30
-3.08
Decrease
-1.30
1BNI
T6Q
25.00
6.30
-1.87
Decrease
-1.69
1BNI
T6S
25.00
6.30
-0.22
Decrease
-1.12
1BNI
A32C
25.00
6.30
-1.00
Decrease
-0.27
1BNI
A32D
25.00
6.30
-0.70
Decrease
-0.70
1BNI
A32E
25.00
6.30
-0.60
Decrease
-0.70
1BNI
A32F
25.00
6.30
-0.70
Decrease
-0.58
1BNI
A32G
25.00
6.30
-0.90
Decrease
-1.57
1BNI
A32H
25.00
6.30
-0.80
Decrease
-0.56
1BNI
A32I
25.00
6.30
-0.80
Decrease
0.36
1BNI
A32K
25.00
6.30
-0.20
Decrease
-2.14
1BNI
A32L
25.00
6.30
-0.30
Decrease
-0.14
1BNI
A32M
25.00
6.30
-0.30
Decrease
-0.56
1BNI
A32N
25.00
6.30
-0.70
Decrease
-1.39
1BNI
A32P
25.00
6.30
-4.10
Decrease
-1.20
1BNI
A32Q
25.00
6.30
-0.50
Decrease
-0.80
1BNI
A32R
25.00
6.30
-0.10
Decrease
-0.71
1BNI
A32S
25.00
6.30
-0.40
Decrease
-1.15
1BNI
A32T
25.00
6.30
-0.80
Decrease
-1.24
1BNI
A32V
25.00
6.30
-0.90
Decrease
-0.63
1BNI
A32W
25.00
6.30
-1.00
Decrease
-0.68
1BNI
A32Y
25.00
6.30
-0.80
Decrease
-1.52
1BNI
D12A
25.00
6.30
0.43
Decrease
-1.28
1BNI
D12A
25.00
6.30
-0.30
Decrease
-1.28
1BNI
D12G
25.00
4.40
-0.78
Decrease
-1.12
1BNI
D12G
25.00
6.30
-1.29
Decrease
-1.19
1BNI
D12S
25.00
6.30
-0.65
Decrease
-0.93
1BNI
D22M
25.00
4.40
-0.27
Decrease
0.55
1BNI
D44E
25.00
6.30
0.10
Increase
-1.02
1BNI
D54A
25.00
6.30
-3.00
Decrease
-2.50
1BNI
D54A
25.00
6.30
-3.30
Decrease
-2.50
1BNI
D54N
25.00
4.40
-2.46
Decrease
-2.38
1BNI
D54N
25.00
4.40
-2.65
Decrease
-2.38
1BNI
D54N
25.00
4.40
-2.66
Decrease
-2.38
1BNI
D54N
25.00
6.30
-2.40
Decrease
-2.45
1BNI
D54N
25.00
6.30
-2.60
Decrease
-2.45
1BNI
D54N
25.00
8.90
-2.32
Decrease
-2.46
1BNI
D75N
25.00
6.30
-4.80
Decrease
-1.44
1BNI
D75N
25.00
6.30
-5.00
Decrease
-1.44
1BNI
D93N
25.00
6.30
-4.11
Decrease
-0.69
1BNI
E29A
25.00
6.30
-1.25
Decrease
-0.68
1BNI
E29G
25.00
6.30
-1.80
Decrease
-0.10
1BNI
E29G
25.00
6.30
-1.81
Decrease
-0.10
1BNI
E29Q
25.00
6.30
0.00
Decrease
-1.00
1BNI
E29S
25.00
6.30
-1.23
Decrease
-1.12
1BNI
E73A
25.00
6.30
-2.50
Decrease
-1.20
1BNI
G34A
25.00
6.30
-3.12
Decrease
-1.46
1BNI
G34D
25.00
6.30
-3.39
Decrease
-1.70
1BNI
G34H
25.00
4.40
-2.60
Decrease
-2.01
1BNI
G34H
25.00
6.30
-2.65
Decrease
-1.81
1BNI
G34H
25.00
8.90
-3.15
Decrease
-1.50
1BNI
G34K
25.00
6.30
-3.12
Decrease
-2.03
1BNI
G34N
25.00
6.30
-2.75
Decrease
-1.60
1BNI
G34R
25.00
6.30
-2.42
Decrease
-1.82
1BNI
G34S
25.00
6.30
-3.20
Decrease
-1.23
1BNI
G34T
25.00
6.30
-3.37
Decrease
-1.87
1BNI
G52A
54.10
6.30
-5.30
Decrease
-1.81
1BNI
G52V
54.10
6.30
-8.40
Decrease
-2.34
1BNI
G53A
54.10
6.30
-3.40
Decrease
-1.94
1BNI
G53V
54.10
6.30
-7.80
Decrease
-2.42
1BNI
G65S
25.00
6.30
0.50
Decrease
-2.18
1BNI
H18A
25.00
6.30
-1.85
Decrease
-1.04
1BNI
H18D
25.00
6.30
-2.56
Decrease
-1.27
1BNI
H18G
25.00
5.80
-0.98
Decrease
-1.67
1BNI
H18G
25.00
6.30
-0.70
Decrease
-1.73
1BNI
H18G
25.00
9.00
0.51
Decrease
-2.00
1BNI
H18K
25.00
6.30
-1.19
Decrease
-1.01
1BNI
H18K
25.00
6.30
-1.20
Decrease
-1.01
1BNI
H18N
25.00
6.30
-1.68
Decrease
-4.23
1BNI
H18Q
25.00
6.30
-1.60
Decrease
-0.67
1BNI
H18R
25.00
6.30
-1.17
Decrease
-0.82
1BNI
H18S
25.00
6.30
-2.28
Decrease
-1.46
1BNI
I25A
25.00
6.30
-3.50
Decrease
-3.30
1BNI
I25V
25.00
6.30
-1.10
Decrease
-0.84
1BNI
I51A
25.00
6.30
-4.70
Decrease
-3.28
1BNI
I51V
25.00
4.40
-1.86
Decrease
-1.14
1BNI
I51V
25.00
6.30
-1.80
Decrease
-1.13
1BNI
I55A
25.00
6.30
-1.10
Decrease
-3.06
1BNI
I55T
25.00
6.30
-0.60
Decrease
-3.58
1BNI
I55V
25.00
6.30
-0.30
Decrease
-1.41
1BNI
I55V
25.00
6.30
-0.30
Decrease
-1.41
1BNI
I76A
25.00
6.30
-1.90
Decrease
-3.08
1BNI
I76V
25.00
6.30
-0.80
Decrease
-0.61
1BNI
I88A
25.00
6.30
-4.00
Decrease
-3.04
1BNI
I88A
25.00
6.30
-4.46
Decrease
-3.04
1BNI
I88A
25.00
6.30
-4.46
Decrease
-3.04
1BNI
I88A
48.00
6.30
-3.90
Decrease
-2.92
1BNI
I88L
25.00
6.30
-0.30
Decrease
-1.77
1BNI
I88V
25.00
4.40
-1.47
Decrease
-1.08
1BNI
I88V
25.00
6.30
-1.30
Decrease
-1.13
1BNI
I88V
25.00
6.30
-1.49
Decrease
-1.13
1BNI
I88V
25.00
6.30
-1.49
Decrease
-1.13
1BNI
I88V
48.00
6.30
-1.10
Decrease
-1.07
1BNI
I96A
25.00
6.30
-3.20
Decrease
-3.85
1BNI
I96A
25.00
6.30
-3.33
Decrease
-3.85
1BNI
I96A
25.00
6.30
-3.52
Decrease
-3.85
1BNI
I96A
25.00
6.30
-3.52
Decrease
-3.85
1BNI
I96A
25.00
6.30
-4.00
Decrease
-3.85
1BNI
I96A
48.00
6.30
-3.20
Decrease
-3.64
1BNI
I96V
25.00
4.40
-1.17
Decrease
-1.43
1BNI
I96V
25.00
4.40
-1.18
Decrease
-1.43
1BNI
I96V
25.00
6.30
-0.90
Decrease
-1.50
1BNI
I96V
25.00
6.30
-0.95
Decrease
-1.50
1BNI
I96V
25.00
6.30
-0.98
Decrease
-1.50
1BNI
I96V
25.00
6.30
-0.98
Decrease
-1.50
1BNI
I96V
25.00
6.30
-1.10
Decrease
-1.50
1BNI
I96V
48.00
6.30
-0.90
Decrease
-1.26
1BNI
K19R
25.00
6.30
0.20
Decrease
-1.26
1BNI
K27G
25.00
6.30
-0.40
Decrease
-1.14
1BNI
K27G
25.00
6.30
-0.55
Decrease
-1.14
1BNI
K62R
25.00
6.30
-0.40
Decrease
-0.78
1BNI
K62R
25.00
6.30
-0.50
Decrease
-0.78
1BNI
K66A
25.00
6.30
0.20
Decrease
-0.83
1BNI
L14A
25.00
6.30
-4.30
Decrease
-3.90
1BNI
L14A
25.00
6.30
-4.80
Decrease
-3.90
1BNI
L14A
25.00
6.30
-4.80
Decrease
-3.90
1BNI
L14A
48.00
6.30
-4.20
Decrease
-3.55
1BNI
L33Q
25.00
6.30
-1.30
Decrease
-1.79
1BNI
L89T
25.00
6.30
-2.50
Decrease
-2.72
1BNI
L89V
25.00
6.30
-0.30
Decrease
-0.86
1BNI
L89V
25.00
6.30
-0.30
Decrease
-0.86
1BNI
N23A
25.00
6.30
-2.20
Increase
0.08
1BNI
N41D
25.00
6.30
-2.50
Increase
0.03
1BNI
N58A
25.00
6.30
-2.70
Decrease
-0.88
1BNI
N58D
25.00
6.30
0.50
Decrease
-1.37
1BNI
N77A
25.00
6.30
-1.60
Decrease
-1.20
1BNI
N84A
25.00
6.30
-2.00
Decrease
-2.21
1BNI
Q15I
25.00
6.30
1.00
Decrease
0.04
1BNI
Q31A
25.00
6.30
0.10
Decrease
-0.63
1BNI
Q31A
25.00
6.30
0.10
Decrease
-0.63
1BNI
Q31G
25.00
6.30
-0.98
Decrease
-0.24
1BNI
Q31S
25.00
6.30
-0.20
Decrease
-0.95
1BNI
Q31S
25.00
6.30
-0.20
Decrease
-0.95
1BNI
Q31S
25.00
6.30
-0.25
Decrease
-0.95
1BNI
R69K
25.00
6.30
-3.13
Decrease
-0.95
1BNI
R69M
25.00
4.40
-2.86
Decrease
-0.23
1BNI
R69M
25.00
6.30
-2.12
Decrease
-0.28
1BNI
R69S
25.00
6.30
-2.72
Decrease
-2.42
1BNI
R83K
25.00
6.30
-4.13
Decrease
-1.68
1BNI
R83Q
25.00
4.40
-1.58
Decrease
-3.06
1BNI
R83Q
25.00
6.30
-2.05
Decrease
-3.14
1BNI
S28A
25.00
6.30
0.41
Decrease
-0.30
1BNI
S28E
25.00
6.30
0.40
Increase
0.44
1BNI
S28G
25.00
6.30
-0.45
Decrease
-0.68
1BNI
S85A
25.00
6.30
-0.12
Decrease
-1.67
1BNI
S91A
25.00
4.40
-1.16
Decrease
-2.39
1BNI
S91A
25.00
4.40
-1.38
Decrease
-2.39
1BNI
S91A
25.00
6.30
-1.90
Decrease
-2.53
1BNI
S92A
25.00
4.40
-2.83
Decrease
-1.07
1BNI
S92A
25.00
6.30
-2.80
Decrease
-1.23
1BNI
T16A
25.00
6.30
-0.27
Decrease
-2.69
1BNI
T16G
25.00
6.30
-1.66
Decrease
-1.53
1BNI
T16R
25.00
4.40
0.20
Decrease
-0.98
1BNI
T16R
25.00
6.30
0.50
Decrease
-0.83
1BNI
T16R
25.00
6.30
0.50
Decrease
-0.83
1BNI
T16R
25.00
6.30
-0.48
Decrease
-0.83
1BNI
T16S
25.00
6.30
-1.70
Decrease
-0.88
1BNI
T16S
25.00
6.30
-1.87
Decrease
-0.88
1BNI
T26A
25.00
6.30
-1.90
Decrease
-0.71
1BNI
T26A
25.00
6.30
-2.11
Decrease
-0.71
1BNI
T26A
25.00
6.30
-2.14
Decrease
-0.71
1BNI
T26D
25.00
6.30
-0.08
Decrease
-1.09
1BNI
T26E
25.00
6.30
-0.05
Decrease
-0.74
1BNI
T26G
25.00
4.40
-2.08
Decrease
-1.91
1BNI
T26G
25.00
6.30
-1.50
Decrease
-1.91
1BNI
T26G
25.00
6.30
-1.58
Decrease
-1.91
1BNI
T26N
25.00
6.30
-1.29
Decrease
-0.86
1BNI
T26Q
25.00
6.30
-1.72
Decrease
-1.12
1BNI
T26S
25.00
6.30
-0.56
Decrease
-1.08
1BNI
T26V
25.00
6.30
-2.31
Decrease
-0.82
1BNI
T79V
25.00
6.30
0.30
Decrease
-2.64
1BNI
T99V
25.00
6.30
-2.70
Decrease
-1.07
1BNI
V10A
25.00
6.30
-3.40
Decrease
-2.36
1BNI
V10T
25.00
6.30
-2.50
Decrease
-2.29
1BNI
V36A
25.00
6.30
-1.30
Decrease
-1.25
1BNI
V36T
25.00
6.30
-1.10
Decrease
-1.79
1BNI
V45A
25.00
6.30
-1.80
Decrease
-2.25
1BNI
V45T
25.00
6.30
-2.40
Decrease
-0.76
1BNI
W94F
25.00
5.80
-1.06
Decrease
-2.95
1BNI
W94F
25.00
9.00
-0.60
Decrease
-2.85
1BNI
W94L
25.00
5.80
-1.59
Decrease
-0.86
1BNI
W94L
25.00
8.90
-0.64
Decrease
-0.92
1BNI
W94L
25.00
9.00
-0.66
Decrease
-0.92
1BNI
W94Y
25.00
5.80
-1.27
Decrease
-0.72
1BNI
W94Y
25.00
9.00
-0.99
Decrease
-0.55
1BNI
Y13A
25.00
6.30
-3.30
Decrease
-2.03
1BNI
Y13A
25.00
6.30
-3.71
Decrease
-2.03
1BNI
Y13F
25.00
6.30
-0.41
Decrease
-0.38
1BNI
Y17A
25.00
6.30
-2.00
Decrease
-3.52
1BNI
Y17A
25.00
6.30
-2.26
Decrease
-3.52
1BNI
Y17F
25.00
6.30
-0.30
Increase
-0.26
1BNI
Y17G
25.00
6.30
-4.03
Decrease
-2.70
1BNI
Y17S
25.00
6.30
-2.57
Decrease
-2.50
1BNI
Y24F
25.00
6.30
0.00
Increase
-0.26
1BNI
Y78F
25.00
6.30
-1.40
Decrease
-0.44
1BNI
Y78F
25.00
6.30
-1.50
Decrease
-0.44
1BNI
I109A
25.00
6.30
-2.10
Decrease
-1.68
1BNI
I109V
25.00
6.30
-0.80
Decrease
0.05
1BNI
K108R
25.00
6.30
0.90
Decrease
-0.73
1BNI
Q104A
25.00
6.30
-0.20
Decrease
-1.01
1BNI
R110A
25.00
6.30
-0.40
Decrease
-1.35
1BNI
T105V
25.00
6.30
-2.20
Decrease
-1.27
1BNI
Y103F
25.00
6.30
0.00
Decrease
-0.55
1BPI
D3A
39.00
7.00
0.20
Decrease
1.37
1BPI
E7A
39.00
7.00
-1.50
Decrease
0.56
1BPI
F4A
39.00
7.00
-3.00
Decrease
-1.60
1BPI
L6A
39.00
7.00
-0.60
Decrease
-2.87
1BPI
P2A
39.00
7.00
-1.30
Decrease
-0.59
1BPI
P8A
39.00
7.00
-0.30
Decrease
-1.00
1BPI
P9A
39.00
7.00
-0.80
Decrease
-1.02
1BPI
R1A
39.00
7.00
-0.50
Decrease
-0.60
1BPI
D50A
39.00
7.00
-0.40
Decrease
-0.85
1BPI
E49A
39.00
7.00
-0.20
Decrease
-1.05
1BPI
F22A
25.00
2.00
-1.20
Decrease
-3.09
1BPI
F22A
39.00
7.00
-2.00
Decrease
-2.53
1BPI
F45A
25.00
2.00
-6.90
Decrease
-3.19
1BPI
G12A
39.00
7.00
-1.80
Decrease
-0.66
1BPI
G28A
39.00
7.00
-1.00
Decrease
-1.45
1BPI
G36A
39.00
7.00
-2.10
Decrease
-1.64
1BPI
G36S
72.60
4.60
-0.70
Decrease
-0.35
1BPI
G37A
25.00
2.00
-4.90
Decrease
-1.25
1BPI
G37A
39.00
7.00
-2.30
Decrease
-1.07
1BPI
G56A
39.00
7.00
-0.20
Decrease
-0.41
1BPI
G57A
39.00
7.00
-0.20
Decrease
-0.34
1BPI
I18A
39.00
7.00
-1.50
Decrease
-2.37
1BPI
I19A
39.00
7.00
-2.10
Decrease
-1.72
1BPI
K15A
39.00
7.00
-0.40
Decrease
-0.51
1BPI
K26A
39.00
7.00
0.00
Decrease
-0.48
1BPI
K41A
39.00
7.00
-0.40
Decrease
-0.80
1BPI
K46A
39.00
7.00
0.10
Decrease
-0.88
1BPI
L29A
39.00
7.00
0.00
Decrease
-3.96
1BPI
M52A
39.00
7.00
-1.70
Decrease
-1.86
1BPI
N24A
39.00
7.00
-2.20
Decrease
-1.94
1BPI
N43G
25.00
2.00
-5.70
Decrease
-3.35
1BPI
N43G
25.00
2.00
-5.70
Decrease
-3.35
1BPI
N44A
39.00
7.00
-3.30
Decrease
-1.74
1BPI
N44G
25.00
2.00
-4.70
Decrease
-5.43
1BPI
P13A
39.00
7.00
-1.20
Decrease
-1.40
1BPI
Q31A
39.00
7.00
-1.00
Decrease
-0.34
1BPI
R17A
39.00
7.00
-0.30
Decrease
-0.84
1BPI
R20A
39.00
7.00
-1.80
Decrease
0.21
1BPI
R39A
39.00
7.00
0.00
Decrease
-0.84
1BPI
R42A
39.00
7.00
-0.50
Decrease
-1.18
1BPI
R53A
39.00
7.00
-0.10
Decrease
0.24
1BPI
S47A
39.00
7.00
-1.60
Decrease
-0.22
1BPI
T11A
39.00
7.00
0.00
Decrease
-0.27
1BPI
T32A
39.00
7.00
-0.10
Decrease
-1.17
1BPI
T54A
39.00
7.00
-0.10
Decrease
-0.39
1BPI
V34A
39.00
7.00
-1.20
Decrease
-1.85
1BPI
Y10A
39.00
7.00
-1.20
Decrease
-2.43
1BPI
Y23A
25.00
2.00
-5.90
Decrease
-2.47
1BPI
Y35A
39.00
7.00
-1.10
Decrease
-3.97
1BPI
Y35G
25.00
2.00
-5.00
Decrease
-3.12
1BPI
Y35G
25.00
2.00
-5.00
Decrease
-3.12
1BTA
C82A
25.00
7.40
0.48
Decrease
-0.28
1BVC
E4A
25.00
4.00
-0.55
Decrease
-0.11
1BVC
E4A
25.00
4.00
-0.70
Decrease
-0.11
1BVC
L9A
82.20
9.60
-0.40
Decrease
-1.71
1BVC
Q8A
4.00
4.20
0.89
Decrease
-0.25
1BVC
Q8A
4.00
4.20
1.07
Decrease
-0.25
1BVC
Q8G
4.00
4.20
-0.50
Decrease
-0.55
1BVC
Q8G
4.00
4.20
-0.63
Decrease
-0.55
1BVC
W7F
4.00
7.80
0.10
Decrease
-0.56
1BVC
W7F
4.00
7.80
-0.90
Decrease
-0.56
1BVC
W7F
4.00
7.80
-1.10
Decrease
-0.56
1BVC
D44A
25.00
4.00
-0.15
Decrease
0.06
1BVC
D44A
25.00
4.00
-0.20
Decrease
0.06
1BVC
D60A
25.00
4.00
-0.10
Decrease
0.69
1BVC
D60A
25.00
4.00
-0.15
Decrease
0.69
1BVC
E18A
25.00
4.00
-0.50
Decrease
-0.32
1BVC
E18A
25.00
4.00
-0.70
Decrease
-0.32
1BVC
G23A
82.20
9.60
-1.10
Decrease
0.50
1BVC
H36Q
4.00
7.80
-0.10
Decrease
-1.39
1BVC
H36Q
4.00
7.80
-0.70
Decrease
-1.39
1BVC
H36Q
4.00
7.80
-0.80
Decrease
-1.39
1BVC
I28A
76.50
11.00
-1.30
Decrease
-2.26
1BVC
I28L
76.50
11.00
-0.60
Decrease
-0.36
1BVC
I28M
76.50
11.00
-0.60
Decrease
-1.68
1BVC
I28V
76.50
11.00
0.00
Decrease
-0.60
1BVC
K56A
25.00
4.00
-0.20
Decrease
0.12
1BVC
K56A
25.00
4.00
-0.25
Decrease
0.12
1BVC
K77A
25.00
4.00
-0.02
Decrease
-0.05
1BVC
K77A
25.00
4.00
-0.05
Decrease
-0.05
1BVC
L11A
82.20
9.60
-0.40
Decrease
-2.11
1BVC
L29A
76.50
11.00
-2.40
Decrease
-1.69
1BVC
L29I
76.50
11.00
-1.10
Decrease
-0.81
1BVC
L29M
76.50
11.00
0.10
Decrease
-0.77
1BVC
L29V
76.50
11.00
-1.70
Decrease
-1.03
1BVC
L49I
76.50
11.00
-0.80
Decrease
-0.58
1BVC
L69A
76.50
11.00
-1.20
Decrease
-0.85
1BVC
L69I
76.50
11.00
0.00
Decrease
-0.07
1BVC
L69M
76.50
11.00
0.00
Decrease
-0.05
1BVC
L69V
76.50
11.00
-0.10
Decrease
-0.41
1BVC
P88A
82.20
9.60
0.60
Decrease
-0.43
1BVC
T51A
82.20
9.60
-1.40
Decrease
-1.20
1BVC
T67A
82.20
9.60
-0.30
Decrease
-0.07
1BVC
V13A
82.20
9.60
-0.70
Decrease
-0.32
1BVC
V66A
82.20
9.60
0.80
Decrease
-2.35
1BVC
V68T
4.00
7.80
-0.20
Decrease
-2.13
1BVC
V68T
4.00
7.80
-0.40
Decrease
-2.13
1BVC
V68T
4.00
7.80
-0.60
Decrease
-2.13
1BVC
W14F
4.00
7.80
-0.50
Decrease
-1.57
1BVC
W14F
4.00
7.80
-0.60
Decrease
-1.57
1BVC
W14F
4.00
7.80
-1.10
Decrease
-1.57
1BVC
A130K
4.00
7.80
-0.90
Decrease
-2.52
1BVC
A130K
4.00
7.80
-1.20
Decrease
-2.52
1BVC
A130K
4.00
7.80
-2.10
Decrease
-2.52
1BVC
A130L
4.00
7.80
0.10
Decrease
-0.38
1BVC
A130L
4.00
7.80
-0.90
Decrease
-0.38
1BVC
A130L
4.00
7.80
-1.00
Decrease
-0.38
1BVC
E109A
4.00
4.20
0.17
Decrease
-0.65
1BVC
E109A
4.00
4.20
0.36
Decrease
-0.65
1BVC
E109G
4.00
4.20
-0.89
Decrease
-0.38
1BVC
E109G
4.00
4.20
-0.96
Decrease
-0.38
1BVC
F123K
4.00
7.80
-0.70
Decrease
-1.97
1BVC
F123K
4.00
7.80
-1.40
Decrease
-1.97
1BVC
F123K
4.00
7.80
-2.10
Decrease
-1.97
1BVC
G129A
82.20
9.60
1.10
Increase
-0.63
1BVC
H116A
82.20
9.60
0.20
Decrease
-0.96
1BVC
I111A
76.50
11.00
-1.80
Decrease
-1.90
1BVC
I111L
76.50
11.00
-0.60
Decrease
-0.22
1BVC
I111M
76.50
11.00
-1.10
Decrease
-0.62
1BVC
I142A
76.50
11.00
-1.10
Decrease
-1.60
1BVC
I142A
82.20
9.60
-1.90
Decrease
-1.54
1BVC
I142L
76.50
11.00
0.60
Decrease
0.34
1BVC
I142M
76.50
11.00
0.90
Decrease
-0.86
1BVC
I142V
76.50
11.00
-0.10
Increase
0.74
1BVC
K140A
4.00
4.20
0.35
Decrease
-1.30
1BVC
K140A
4.00
4.20
0.60
Decrease
-1.30
1BVC
L135I
76.50
11.00
-1.50
Decrease
-1.20
1BVC
L135M
76.50
11.00
-0.80
Decrease
-0.25
1BVC
L135V
76.50
11.00
-2.20
Decrease
-1.43
1BVC
L137A
82.20
9.60
-1.80
Decrease
-2.04
1BVC
L149A
82.20
9.60
-1.60
Decrease
-1.63
1BVC
M131A
4.00
7.80
-0.90
Decrease
-1.46
1BVC
M131A
4.00
7.80
-1.30
Decrease
-1.46
1BVC
M131A
4.00
7.80
-2.20
Decrease
-1.46
1BVC
S117A
82.20
9.60
-0.30
Decrease
-0.19
1BVC
V114A
82.20
9.60
-1.40
Decrease
-1.74
1C2R
G34S
30.00
7.50
-2.20
Decrease
-0.80
1C2R
K12D
25.00
7.50
-1.30
Decrease
-1.68
1C2R
K14E
25.00
7.50
-1.30
Decrease
-0.72
1C2R
K32E
25.00
7.50
0.20
Decrease
-0.70
1C2R
P35A
30.00
7.50
-2.00
Decrease
-2.27
1C9O
Q2L
70.00
7.00
0.29
Increase
1.28
1C9O
Q2L
70.00
7.00
0.29
Increase
1.28
1C9O
Q2L
70.00
7.00
0.55
Increase
1.28
1C9O
Q2L
70.00
7.00
0.55
Increase
1.28
1C9O
R3A
70.00
7.00
-1.05
Decrease
0.67
1C9O
R3A
70.00
7.00
-1.89
Decrease
0.67
1C9O
R3E
70.00
7.00
-1.00
Decrease
-0.41
1C9O
R3E
70.00
7.00
-1.00
Decrease
-0.41
1C9O
R3E
70.00
7.00
-2.75
Decrease
-0.41
1C9O
R3E
70.00
7.00
-2.75
Decrease
-0.41
1C9O
R3K
70.00
7.00
-0.14
Decrease
-2.07
1C9O
R3K
70.00
7.00
-0.19
Decrease
-2.07
1C9O
R3L
70.00
7.00
-0.22
Increase
0.35
1C9O
R3L
70.00
7.00
-0.93
Increase
0.35
1C9O
E46A
70.00
7.00
-0.12
Decrease
-0.23
1C9O
E46A
70.00
7.00
-0.12
Decrease
-0.23
1C9O
E46A
70.00
7.00
-0.22
Decrease
-0.23
1C9O
E46A
70.00
7.00
-0.22
Decrease
-0.23
1C9O
G23Q
70.00
7.00
-0.29
Decrease
-1.27
1C9O
G23Q
70.00
7.00
-0.29
Decrease
-1.27
1C9O
G23Q
70.00
7.00
-0.31
Decrease
-1.27
1C9O
G23Q
70.00
7.00
-0.31
Decrease
-1.27
1C9O
L66E
70.00
7.00
-1.24
Decrease
-1.69
1C9O
L66E
70.00
7.00
-1.24
Decrease
-1.69
1C9O
L66E
70.00
7.00
-1.27
Decrease
-1.69
1C9O
L66E
70.00
7.00
-1.27
Decrease
-1.69
1C9O
N11S
70.00
7.00
0.22
Decrease
-0.40
1C9O
N11S
70.00
7.00
0.22
Decrease
-0.40
1C9O
N11S
70.00
7.00
0.33
Decrease
-0.40
1C9O
N11S
70.00
7.00
0.33
Decrease
-0.40
1C9O
Q53E
70.00
7.00
0.00
Decrease
-0.16
1C9O
Q53E
70.00
7.00
0.00
Decrease
-0.16
1C9O
Q53E
70.00
7.00
-0.10
Decrease
-0.16
1C9O
Q53E
70.00
7.00
-0.10
Decrease
-0.16
1C9O
S24D
70.00
7.00
0.19
Decrease
-1.29
1C9O
S24D
70.00
7.00
0.19
Decrease
-1.29
1C9O
S24D
70.00
7.00
0.22
Decrease
-1.29
1C9O
S24D
70.00
7.00
0.22
Decrease
-1.29
1C9O
T31S
70.00
7.00
0.17
Increase
0.38
1C9O
T31S
70.00
7.00
0.17
Increase
0.38
1C9O
T31S
70.00
7.00
0.19
Increase
0.38
1C9O
T31S
70.00
7.00
0.19
Increase
0.38
1C9O
V64T
70.00
7.00
-0.19
Decrease
-1.43
1C9O
V64T
70.00
7.00
-0.19
Decrease
-1.43
1C9O
V64T
70.00
7.00
-0.26
Decrease
-1.43
1C9O
V64T
70.00
7.00
-0.26
Decrease
-1.43
1C9O
Y15F
70.00
7.00
0.07
Increase
0.67
1C9O
Y15F
70.00
7.00
0.07
Increase
0.67
1C9O
Y15F
70.00
7.00
-0.05
Increase
0.67
1C9O
Y15F
70.00
7.00
-0.05
Increase
0.67
1CAH
W5F
23.00
7.50
0.10
Decrease
-0.66
1CAH
W5F
23.00
7.50
-2.50
Decrease
-0.66
1CAH
W16F
23.00
7.50
0.30
Decrease
-1.62
1CAH
W16F
23.00
7.50
-6.30
Decrease
-1.62
1CAH
C206S
23.00
7.50
0.10
Decrease
-0.78
1CAH
C206S
23.00
7.50
-0.70
Decrease
-0.78
1CHK
W28F
42.70
7.00
-3.56
Decrease
-0.83
1CHK
W28F
43.20
7.00
-4.43
Decrease
-0.82
1CHK
W28F
52.20
7.00
-1.76
Decrease
-0.80
1CHK
W101F
42.70
7.00
-3.91
Decrease
-0.06
1CHK
W101F
43.20
7.00
-4.27
Decrease
-0.07
1CHK
W101F
52.20
7.00
-1.89
Decrease
-0.08
1CHK
W227F
42.70
7.00
-2.97
Decrease
-1.42
1CHK
W227F
43.20
7.00
-2.51
Decrease
-1.41
1CHK
W227F
52.20
7.00
-1.31
Decrease
-1.36
1CSP
E3L
70.00
7.00
0.41
Increase
1.17
1CSP
E3L
70.00
7.00
1.60
Increase
1.17
1CSP
E3R
70.00
7.00
0.77
Decrease
0.81
1CSP
E3R
70.00
7.00
0.77
Decrease
0.81
1CSP
E3R
70.00
7.00
2.66
Decrease
0.81
1CSP
E3R
70.00
7.00
2.66
Decrease
0.81
1CSP
E66L
70.00
7.00
1.44
Increase
1.42
1CSP
E66L
70.00
7.00
1.44
Increase
1.42
1CSP
E66L
70.00
7.00
2.11
Increase
1.42
1CSP
E66L
70.00
7.00
2.11
Increase
1.42
1CSP
F15A
60.00
7.00
-1.67
Decrease
-1.29
1CSP
F17A
60.00
7.00
-1.34
Decrease
-1.95
1CSP
F27A
60.00
7.00
-0.69
Decrease
-1.07
1CSP
F38A
60.00
7.00
0.31
Decrease
-0.85
1CYO
F35H
66.20
7.00
-2.82
Decrease
-1.61
1CYO
F35L
66.20
7.00
-1.87
Decrease
-1.58
1CYO
F35Y
66.20
7.00
0.79
Decrease
-0.37
1CYO
V45E
66.70
7.00
-2.68
Decrease
-0.46
1CYO
V45E
77.60
7.00
-2.06
Decrease
-0.47
1CYO
V45G
25.00
7.00
-1.91
Decrease
-2.69
1CYO
V45H
25.00
7.00
-1.65
Decrease
-1.50
1CYO
V45H
66.70
7.00
-1.34
Decrease
-1.49
1CYO
V45H
77.60
7.00
-1.39
Decrease
-1.48
1CYO
V45T
25.00
7.00
-0.96
Decrease
-1.36
1CYO
V45Y
66.70
7.00
-1.53
Decrease
-0.49
1CYO
V45Y
77.60
7.00
-1.56
Decrease
-0.54
1CYO
V61E
25.00
7.00
-1.05
Decrease
-2.62
1CYO
V61E
67.20
7.00
-1.10
Decrease
-2.78
1CYO
V61H
25.00
7.00
-1.60
Decrease
-1.81
1CYO
V61H
67.20
7.00
-1.63
Decrease
-1.77
1CYO
V61K
25.00
7.00
-2.39
Decrease
-1.36
1CYO
V61K
67.20
7.00
-2.34
Decrease
-1.42
1CYO
V61Y
25.00
7.00
-1.34
Decrease
-1.61
1CYO
V61Y
67.20
7.00
-1.29
Decrease
-1.78
1EL1
A93S
66.40
4.50
-0.26
Decrease
-1.13
1EL1
H21G
66.40
4.50
-0.48
Decrease
-0.40
1EL1
I56L
66.40
4.50
-0.24
Decrease
0.32
1EL1
V109K
66.40
4.50
-0.43
Decrease
-1.47
1EM7
I6N
25.00
5.20
2.07
Decrease
-1.25
1EM7
I6N
63.00
5.20
1.82
Decrease
-1.00
1EM7
I6T
25.00
5.20
2.00
Decrease
-2.21
1EM7
I6T
63.00
5.20
1.76
Decrease
-2.14
1EM7
T53F
25.00
5.20
4.61
Increase
0.86
1EM7
T53F
63.00
5.20
4.10
Increase
0.91
1EM7
T53I
25.00
5.20
3.30
Increase
0.38
1EM7
T53I
63.00
5.20
3.81
Increase
0.67
1EM7
T53V
25.00
5.20
2.80
Increase
0.30
1EM7
T53V
63.00
5.20
3.38
Increase
0.70
1EM7
T53Y
25.00
5.20
4.10
Increase
1.52
1EM7
T53Y
63.00
5.20
4.29
Increase
1.44
1G6N
S128A
20.00
7.90
-0.26
Decrease
0.31
1G6N
S128P
20.00
7.90
0.14
Decrease
-2.06
1HFY
A30I
20.00
2.00
0.30
Decrease
0.89
1HFY
A30T
20.00
2.00
0.06
Decrease
-1.15
1HFY
T29I
20.00
2.00
0.12
Increase
-0.29
1HFY
T33I
20.00
2.00
0.18
Increase
0.16
1HUE
A27S
63.90
7.00
-1.19
Decrease
-0.25
1HUE
A56S
63.90
7.00
-0.13
Decrease
-0.91
1HUE
M69I
63.90
7.00
0.00
Decrease
-0.45
1HUE
S31T
63.90
7.00
0.41
Increase
0.48
1HUE
V42I
63.90
7.00
-0.82
Decrease
0.00
1IGV
D19N
25.00
7.00
0.74
Decrease
-0.77
1IGV
E17Q
25.00
7.00
0.38
Decrease
-0.42
1IGV
E26Q
25.00
7.00
0.09
Increase
0.37
1IOB
T9A
25.00
6.50
-0.80
Decrease
-1.59
1IOB
T9G
25.00
6.50
-2.60
Decrease
-1.55
1IOB
T9L
25.00
6.50
-0.70
Decrease
-1.13
1IOB
T9Q
25.00
6.50
-1.90
Decrease
-1.23
1IOB
K97G
25.00
6.50
-1.20
Decrease
-0.34
1IOB
K97R
25.00
6.50
-0.50
Increase
-0.40
1IOB
K97V
25.00
6.50
0.80
Increase
-0.66
1LZ1
A9S
64.90
2.70
-0.02
Decrease
-0.96
1LZ1
E7Q
65.00
2.20
0.10
Increase
-0.16
1LZ1
E7Q
65.00
2.30
-0.43
Increase
-0.15
1LZ1
E7Q
65.00
4.00
-1.44
Increase
-0.05
1LZ1
E7Q
65.00
4.50
-1.29
Increase
-0.02
1LZ1
K1A
64.90
2.70
-0.60
Decrease
0.15
1LZ1
K1M
64.90
2.70
-0.12
Increase
0.55
1LZ1
L8T
64.90
2.70
-3.73
Decrease
-2.65
1LZ1
V2A
49.20
2.70
-1.51
Decrease
-1.12
1LZ1
V2A
64.90
2.70
-1.51
Decrease
-1.04
1LZ1
V2D
64.90
2.70
-1.44
Decrease
-1.16
1LZ1
V2F
64.90
2.70
-0.86
Decrease
-0.84
1LZ1
V2G
64.90
2.70
-2.30
Decrease
-2.92
1LZ1
V2I
64.90
2.70
1.10
Decrease
0.68
1LZ1
V2L
64.90
2.70
-0.05
Increase
0.37
1LZ1
V2M
64.90
2.70
-0.31
Decrease
-0.87
1LZ1
V2N
64.90
2.70
-1.34
Decrease
-2.00
1LZ1
V2R
64.90
2.70
-0.38
Decrease
-1.12
1LZ1
V2S
64.90
2.70
-1.41
Decrease
-0.96
1LZ1
V2Y
64.90
2.70
-0.36
Decrease
-0.77
1LZ1
A32L
64.90
2.70
-0.10
Decrease
0.81
1LZ1
A32S
64.90
2.70
-0.33
Decrease
-0.17
1LZ1
A47P
68.80
2.80
0.10
Increase
-0.67
1LZ1
A92S
64.90
2.70
0.81
Decrease
-0.58
1LZ1
A96M
64.90
2.70
0.02
Decrease
-0.26
1LZ1
A96S
64.90
2.70
-1.00
Decrease
-0.05
1LZ1
C77A
57.00
3.00
-4.60
Decrease
0.43
1LZ1
D18N
65.00
2.20
-0.53
Decrease
-1.05
1LZ1
D18N
65.00
4.00
-1.70
Decrease
-1.09
1LZ1
D49N
65.00
2.20
0.00
Decrease
-1.95
1LZ1
D49N
65.00
4.00
-1.00
Decrease
-1.99
1LZ1
D67N
65.00
2.20
-0.24
Increase
-0.37
1LZ1
D67N
65.00
2.30
-0.26
Increase
-0.38
1LZ1
D67N
65.00
4.00
-2.25
Increase
-0.44
1LZ1
D67N
65.00
4.50
-1.70
Increase
-0.45
1LZ1
D91P
68.80
2.80
-0.40
Decrease
-0.46
1LZ1
E35L
64.90
2.70
-0.53
Increase
1.80
1LZ1
G37A
64.90
2.70
-0.29
Decrease
-0.44
1LZ1
G37Q
64.90
2.70
-0.26
Decrease
-0.26
1LZ1
G37Q
64.90
2.70
-0.26
Decrease
-0.26
1LZ1
H78A
64.90
2.70
-0.14
Increase
0.41
1LZ1
H78G
64.90
2.70
-0.12
Decrease
-0.40
1LZ1
H78G
64.90
2.70
-0.12
Decrease
-0.40
1LZ1
I23A
64.90
2.70
-2.54
Decrease
-1.99
1LZ1
I23V
49.20
2.70
-0.41
Decrease
-0.86
1LZ1
I23V
64.90
2.70
-0.36
Decrease
-0.64
1LZ1
I56A
64.90
2.70
-3.71
Decrease
-2.24
1LZ1
I56A
64.90
2.70
-3.71
Decrease
-2.24
1LZ1
I56F
64.90
2.70
-4.09
Decrease
-1.78
1LZ1
I56L
64.90
2.70
-0.10
Decrease
-0.18
1LZ1
I56M
64.90
2.70
-1.77
Decrease
-1.73
1LZ1
I56T
64.90
2.70
-3.64
Decrease
-3.23
1LZ1
I56T
64.90
2.70
-3.64
Decrease
-3.23
1LZ1
I56V
49.20
2.70
-1.34
Decrease
-1.61
1LZ1
I56V
64.90
2.70
-1.20
Decrease
-1.48
1LZ1
I56V
64.90
2.70
-1.20
Decrease
-1.48
1LZ1
I59A
49.20
2.70
-1.32
Decrease
-3.59
1LZ1
I59A
64.90
2.70
-1.72
Decrease
-3.42
1LZ1
I59A
64.90
2.70
-1.72
Decrease
-3.42
1LZ1
I59F
64.90
2.70
-0.81
Decrease
-2.43
1LZ1
I59G
64.90
2.70
-3.83
Decrease
-2.32
1LZ1
I59G
64.90
2.70
-3.83
Decrease
-2.32
1LZ1
I59L
64.90
2.70
0.00
Decrease
-0.16
1LZ1
I59M
64.90
2.70
-1.29
Decrease
-1.46
1LZ1
I59S
64.90
2.70
-3.59
Decrease
-2.84
1LZ1
I59T
64.90
2.70
-2.22
Decrease
-3.00
1LZ1
I59V
49.20
2.70
-0.93
Decrease
-1.20
1LZ1
I59V
64.90
2.70
-1.10
Decrease
-1.05
1LZ1
I59V
64.90
2.70
-1.10
Decrease
-1.05
1LZ1
I59Y
64.90
2.70
-3.78
Decrease
-2.21
1LZ1
I89A
64.90
2.70
-2.70
Decrease
-1.95
1LZ1
I89V
49.20
2.70
-0.35
Decrease
-1.19
1LZ1
I89V
64.90
2.70
-0.48
Decrease
-1.04
1LZ1
P71G
68.80
2.80
-1.60
Decrease
-1.42
1LZ1
Q58A
64.90
2.70
0.91
Decrease
-0.16
1LZ1
Q58G
64.90
2.70
1.87
Decrease
-0.57
1LZ1
Q58G
64.90
2.70
1.87
Decrease
-0.57
1LZ1
R21A
64.90
2.70
1.32
Decrease
0.36
1LZ1
R21G
64.90
2.70
1.15
Decrease
-0.37
1LZ1
R50A
64.90
2.70
0.43
Decrease
-0.54
1LZ1
R50G
64.90
2.70
0.26
Decrease
-0.07
1LZ1
R50G
64.90
2.70
0.26
Decrease
-0.07
1LZ1
V74A
49.20
2.70
-0.43
Decrease
-0.31
1LZ1
V74A
64.90
2.70
-0.36
Decrease
-0.20
1LZ1
V74D
64.90
2.70
-0.43
Decrease
-0.31
1LZ1
V74F
64.90
2.70
-0.29
Decrease
-1.52
1LZ1
V74G
64.90
2.70
-0.22
Decrease
-2.92
1LZ1
V74I
64.90
2.70
0.45
Decrease
1.27
1LZ1
V74L
64.90
2.70
0.19
Decrease
0.42
1LZ1
V74M
64.90
2.70
0.65
Decrease
0.00
1LZ1
V74N
64.90
2.70
-0.33
Decrease
-1.19
1LZ1
V74R
64.90
2.70
-0.07
Decrease
-0.07
1LZ1
V74S
64.90
2.70
-0.38
Decrease
-0.68
1LZ1
V74S
64.90
2.70
-0.38
Decrease
-0.68
1LZ1
V74Y
64.90
2.70
-0.24
Decrease
-0.42
1LZ1
V93A
49.20
2.70
-1.00
Decrease
-0.99
1LZ1
V93A
64.90
2.70
-0.74
Decrease
-0.84
1LZ1
V93T
64.90
2.70
-0.67
Decrease
-0.30
1LZ1
V99A
49.20
2.70
-0.89
Decrease
-0.34
1LZ1
V99A
64.90
2.70
-0.98
Decrease
-0.22
1LZ1
V99T
64.90
2.70
-0.50
Decrease
-0.24
1LZ1
Y20F
64.90
2.70
-0.50
Decrease
0.12
1LZ1
Y38A
64.90
2.70
-2.49
Decrease
-1.43
1LZ1
Y38F
64.90
2.70
-0.19
Decrease
-0.05
1LZ1
Y38G
64.90
2.70
-2.32
Decrease
-4.58
1LZ1
Y45F
64.90
2.70
0.07
Decrease
-0.49
1LZ1
Y54F
64.90
2.70
-0.96
Decrease
-0.54
1LZ1
Y63F
64.90
2.70
-0.24
Decrease
-0.90
1LZ1
D102N
65.00
2.20
0.17
Decrease
-0.12
1LZ1
D102N
65.00
2.30
0.14
Decrease
-0.12
1LZ1
D102N
65.00
4.00
-0.67
Decrease
-0.11
1LZ1
D102N
65.00
4.50
0.07
Decrease
-0.10
1LZ1
D120N
65.00
2.20
0.10
Decrease
-0.69
1LZ1
D120N
65.00
2.30
0.19
Decrease
-0.69
1LZ1
D120N
65.00
4.00
-0.67
Decrease
-0.77
1LZ1
D120N
65.00
4.50
0.05
Decrease
-0.79
1LZ1
I106A
64.90
2.70
-0.93
Decrease
-1.93
1LZ1
I106V
49.20
2.70
-0.98
Decrease
1.15
1LZ1
I106V
64.90
2.70
-0.72
Decrease
1.26
1LZ1
N118A
64.90
2.70
0.19
Decrease
-0.55
1LZ1
N118G
64.90
2.70
0.05
Decrease
-2.27
1LZ1
P103G
68.80
2.80
-0.10
Decrease
-1.02
1LZ1
V100A
49.20
2.70
-0.57
Decrease
-0.96
1LZ1
V100A
64.90
2.70
-0.26
Decrease
-0.86
1LZ1
V100F
64.90
2.70
-1.65
Decrease
-0.94
1LZ1
V100T
64.90
2.70
-0.29
Decrease
-0.19
1LZ1
V110A
49.20
2.70
0.07
Increase
-0.07
1LZ1
V110A
64.90
2.70
0.53
Increase
0.08
1LZ1
V110D
64.90
2.70
0.17
Increase
0.59
1LZ1
V110F
64.90
2.70
-0.05
Increase
0.05
1LZ1
V110G
64.90
2.70
0.48
Increase
-0.57
1LZ1
V110I
64.90
2.70
0.86
Increase
1.17
1LZ1
V110L
64.90
2.70
0.07
Increase
0.92
1LZ1
V110M
64.90
2.70
0.53
Increase
0.13
1LZ1
V110N
64.90
2.70
0.07
Increase
-0.19
1LZ1
V110P
68.80
2.80
0.50
Increase
-1.02
1LZ1
V110R
64.90
2.70
0.89
Increase
0.36
1LZ1
V110Y
64.90
2.70
-0.14
Increase
-0.16
1LZ1
V121A
49.20
2.70
-1.75
Decrease
-1.14
1LZ1
V121A
64.90
2.70
-1.44
Decrease
-0.96
1LZ1
V125A
49.20
2.70
-1.60
Decrease
-1.79
1LZ1
V125A
64.90
2.70
-1.32
Decrease
-1.66
1LZ1
V130A
49.20
2.70
-1.12
Decrease
-2.03
1LZ1
V130A
64.90
2.70
-0.84
Decrease
-1.96
1LZ1
Y124F
64.90
2.70
-0.36
Increase
0.31
1MBG
V103A
25.00
7.50
-2.32
Decrease
-0.81
1MBG
V103I
25.00
7.50
0.69
Decrease
0.08
1MBG
V103L
25.00
7.50
2.44
Decrease
-0.85
1N0J
I58T
70.00
7.80
-2.70
Decrease
-1.79
1ONC
M23L
25.00
2.00
-2.51
Decrease
-1.23
1ONC
M23L
25.00
2.50
-2.30
Decrease
-1.26
1ONC
M23L
25.00
3.00
-2.78
Decrease
-1.31
1ONC
M23L
25.00
3.50
-2.89
Decrease
-1.34
1ONC
M23L
25.00
4.00
-2.42
Decrease
-1.37
1ONC
M23L
25.00
5.00
-2.66
Decrease
-1.43
1ONC
M23L
25.00
6.00
-2.66
Decrease
-1.48
1ONC
M23L
25.00
7.00
-2.22
Decrease
-1.53
1ONC
M23L
25.00
8.00
-2.39
Decrease
-1.57
1OTR
V5A
50.00
3.75
-3.01
Decrease
-1.73
1OTR
V5N
50.00
3.75
-5.38
Decrease
-2.94
1OTR
V5T
50.00
3.75
-3.73
Decrease
-1.00
1OTR
E34C
65.00
3.00
0.91
Increase
-0.29
1OTR
E34G
65.00
3.00
1.39
Increase
-1.01
1OTR
E34H
65.00
3.00
-3.92
Increase
0.37
1OTR
E34I
65.00
3.00
1.65
Increase
-0.09
1OTR
E34K
65.00
3.00
-2.15
Decrease
0.17
1OTR
E34L
65.00
3.00
1.36
Increase
-0.66
1OTR
E34P
65.00
3.00
-2.13
Increase
-0.46
1OTR
E34Q
65.00
3.00
-1.46
Increase
0.16
1OTR
E34S
65.00
3.00
0.12
Increase
-0.52
1OTR
E34T
65.00
3.00
1.51
Increase
0.69
1OTR
E34W
65.00
3.00
1.32
Increase
-0.48
1OTR
I30L
50.00
3.00
-1.96
Decrease
-0.90
1OTR
I36F
50.00
3.00
-0.86
Decrease
-1.78
1OTR
I36L
50.00
3.00
-1.32
Decrease
-0.53
1OTR
I36V
50.00
3.00
-0.79
Decrease
-1.24
1OTR
L67A
50.00
3.75
-2.82
Decrease
-3.34
1OTR
L67N
50.00
3.75
-3.40
Decrease
-1.97
1OTR
L67S
50.00
3.75
-3.30
Decrease
-2.10
1OTR
L67T
50.00
3.75
-2.92
Decrease
-3.60
1OTR
Q41L
50.00
3.75
-0.26
Increase
-0.05
1OTR
Q41N
50.00
3.75
-2.56
Decrease
-0.34
1OTR
Q41S
50.00
3.75
-1.27
Decrease
-0.20
1OTR
Q41T
50.00
3.75
-0.43
Decrease
-0.59
1OTR
Q41V
50.00
3.75
-0.05
Decrease
-0.49
1OTR
V17A
50.00
3.75
-1.63
Decrease
-2.55
1OTR
V17N
50.00
3.75
-4.90
Decrease
-3.72
1OTR
V17T
50.00
3.75
-1.89
Decrease
-1.58
1PGA
D46A
25.00
7.00
-1.36
Decrease
-0.23
1PGA
D47A
25.00
7.00
0.36
Decrease
-0.71
1PGA
K50A
25.00
7.00
-0.45
Decrease
0.74
1PGA
T49A
25.00
7.00
-0.86
Decrease
-0.01
1PGA
T53C
60.00
5.20
0.78
Increase
0.79
1PGA
T53D
60.00
5.20
-0.85
Increase
0.66
1PGA
T53E
60.00
5.20
0.23
Increase
0.55
1PGA
T53F
60.00
5.20
1.08
Increase
3.95
1PGA
T53G
60.00
5.20
-1.21
Increase
0.60
1PGA
T53H
60.00
5.20
0.37
Increase
-0.14
1PGA
T53I
60.00
5.20
1.25
Increase
1.53
1PGA
T53K
60.00
5.20
0.35
Increase
0.39
1PGA
T53L
60.00
5.20
0.45
Increase
0.76
1PGA
T53M
60.00
5.20
0.90
Increase
1.01
1PGA
T53N
60.00
5.20
0.52
Increase
0.54
1PGA
T53Q
60.00
5.20
0.38
Increase
-0.50
1PGA
T53R
60.00
5.20
0.40
Increase
1.11
1PGA
T53S
60.00
5.20
0.87
Increase
1.06
1PGA
T53T
60.00
5.20
1.36
Decrease
-1.26
1PGA
T53V
60.00
5.20
0.94
Increase
1.29
1PGA
T53W
60.00
5.20
1.04
Increase
0.48
1PGA
T53Y
60.00
5.20
1.63
Increase
3.93
1PGA
V54A
25.00
7.00
-0.10
Decrease
-2.44
1POH
K49A
25.00
7.00
1.60
Decrease
0.11
1POH
K49D
25.00
7.00
1.80
Increase
0.58
1POH
K49E
25.00
7.00
2.10
Increase
1.07
1POH
K49E
30.00
7.00
1.90
Increase
1.07
1POH
K49E
63.40
7.00
2.10
Increase
0.94
1POH
K49G
25.00
7.00
1.20
Decrease
0.17
1POH
K49M
25.00
7.00
1.00
Increase
0.86
1POH
K49N
25.00
7.00
0.40
Increase
1.49
1POH
K49Q
25.00
7.00
1.50
Increase
1.30
1POH
K49R
25.00
7.00
-0.20
Increase
1.10
1POH
K49S
25.00
7.00
1.20
Increase
1.07
1POH
S46A
30.00
7.00
-0.90
Increase
0.94
1POH
S46A
30.00
7.00
-1.10
Increase
0.94
1POH
S46D
30.00
7.00
1.40
Increase
0.16
1POH
S46D
30.00
7.00
1.50
Increase
0.16
1POH
S46N
30.00
7.00
0.30
Decrease
0.14
1POH
S46N
30.00
7.00
0.50
Decrease
0.14
1RN1
N9A
25.00
7.00
-0.90
Decrease
-2.36
1RN1
N9A
50.90
7.00
-0.71
Decrease
-2.21
1RN1
A21C
0.00
2.50
-0.74
Decrease
-0.25
1RN1
A21D
0.00
2.50
0.33
Decrease
-0.07
1RN1
A21D
0.00
7.00
-0.71
Decrease
-0.09
1RN1
A21E
0.00
2.50
0.05
Decrease
0.16
1RN1
A21E
0.00
7.00
-0.69
Decrease
0.04
1RN1
A21F
0.00
2.50
-0.57
Decrease
-0.32
1RN1
A21G
0.00
2.50
-0.90
Decrease
-1.39
1RN1
A21H
0.00
2.50
-0.56
Decrease
-0.99
1RN1
A21H
0.00
7.00
-0.17
Decrease
-0.95
1RN1
A21I
0.00
2.50
-0.44
Decrease
-0.10
1RN1
A21K
0.00
2.50
-0.51
Decrease
-1.23
1RN1
A21L
0.00
2.50
-0.13
Decrease
0.18
1RN1
A21M
0.00
2.50
-0.15
Decrease
0.08
1RN1
A21N
0.00
2.50
0.34
Decrease
-0.78
1RN1
A21Q
0.00
2.50
-0.26
Decrease
-0.44
1RN1
A21Q
0.00
7.00
-0.40
Decrease
-0.57
1RN1
A21R
0.00
2.50
-0.41
Decrease
0.12
1RN1
A21S
0.00
2.50
-0.49
Decrease
-0.79
1RN1
A21S
0.00
7.00
-0.40
Decrease
-0.89
1RN1
A21T
0.00
2.50
-0.57
Decrease
-0.47
1RN1
A21V
0.00
2.50
-0.66
Increase
-0.49
1RN1
A21W
0.00
2.50
-0.30
Decrease
0.36
1RN1
A21Y
0.00
2.50
-0.39
Decrease
-0.25
1RN1
D49H
25.00
7.00
1.10
Decrease
-1.55
1RN1
D76A
15.00
7.00
-3.70
Decrease
-2.73
1RN1
D76A
15.00
7.00
-3.80
Decrease
-2.73
1RN1
D76N
15.00
7.00
-3.10
Decrease
-2.65
1RN1
D76N
15.00
7.00
-3.10
Decrease
-2.65
1RN1
D76S
15.00
7.00
-3.10
Decrease
-2.07
1RN1
D76S
15.00
7.00
-3.30
Decrease
-2.07
1RN1
E58A
25.00
7.00
-0.77
Decrease
-2.34
1RN1
E58A
48.60
7.00
-0.78
Decrease
-2.31
1RN1
H40T
25.00
6.00
-0.26
Decrease
-1.90
1RN1
H92A
25.00
6.00
-0.62
Decrease
-1.98
1RN1
N36A
25.00
7.00
0.03
Decrease
-1.35
1RN1
N36A
50.90
7.00
0.00
Decrease
-0.84
1RN1
N44A
25.00
7.00
-2.08
Decrease
-1.20
1RN1
N44A
50.80
7.00
-1.60
Decrease
-0.97
1RN1
N44A
50.90
7.00
-1.86
Decrease
-0.97
1RN1
N44D
50.80
7.00
-1.60
Decrease
-0.75
1RN1
N44S
50.80
7.00
-1.50
Decrease
-1.75
1RN1
N81A
25.00
7.00
-2.87
Decrease
-1.86
1RN1
N81A
50.90
7.00
-2.91
Decrease
-1.36
1RN1
Q25K
25.00
7.00
0.94
Decrease
-0.61
1RN1
Q25K
48.60
7.00
0.93
Decrease
-0.48
1RN1
S12A
25.00
7.00
-1.23
Decrease
-0.41
1RN1
S12A
50.90
7.00
-1.08
Decrease
-0.26
1RN1
S17A
25.00
7.00
0.67
Decrease
-1.17
1RN1
S17A
50.90
7.00
0.57
Decrease
-0.97
1RN1
S64A
25.00
7.00
-1.44
Decrease
-0.29
1RN1
S64A
50.90
7.00
-1.56
Decrease
-0.05
1RN1
W59Y
25.00
6.00
-0.93
Decrease
-1.67
1RN1
Y11F
25.00
7.00
-2.11
Decrease
-0.05
1RN1
Y11F
50.90
7.00
-2.03
Decrease
-0.05
1RN1
Y24W
25.00
6.00
1.24
Decrease
-0.34
1RN1
Y42F
25.00
7.00
1.14
Decrease
-0.73
1RN1
Y42F
50.90
7.00
1.15
Decrease
-0.49
1RN1
Y42W
25.00
6.00
-0.14
Increase
0.53
1RN1
Y45W
25.00
6.00
0.74
Decrease
0.08
1RN1
Y56F
25.00
7.00
-0.78
Decrease
-0.49
1RN1
Y56F
50.90
7.00
-0.71
Decrease
-0.53
1RN1
Y57F
25.00
7.00
-0.50
Decrease
-1.08
1RN1
Y57F
50.90
7.00
-0.44
Decrease
-1.10
1RN1
Y68F
25.00
7.00
-1.36
Decrease
-1.15
1RN1
Y68F
50.90
7.00
-1.35
Decrease
-1.03
1ROP
D30A
69.00
7.00
0.30
Decrease
1.19
1ROP
D30C
69.00
7.00
0.80
Increase
0.60
1ROP
D30E
69.00
7.00
1.00
Increase
0.22
1ROP
D30F
69.00
7.00
-0.10
Increase
0.84
1ROP
D30G
69.00
7.00
2.00
Increase
-0.00
1ROP
D30H
69.00
7.00
0.90
Increase
-0.40
1ROP
D30I
69.00
7.00
-0.80
Increase
1.70
1ROP
D30K
69.00
7.00
0.90
Increase
0.29
1ROP
D30L
69.00
7.00
-0.10
Increase
0.38
1ROP
D30M
69.00
7.00
0.60
Increase
1.00
1ROP
D30N
69.00
7.00
0.80
Increase
0.37
1ROP
D30P
69.00
7.00
-1.60
Increase
-0.20
1ROP
D30Q
69.00
7.00
1.80
Increase
-0.01
1ROP
D30R
69.00
7.00
0.80
Increase
-0.05
1ROP
D30S
69.00
7.00
1.00
Increase
1.16
1ROP
D30T
69.00
7.00
-0.40
Increase
0.43
1ROP
D30V
69.00
7.00
-0.40
Increase
0.98
1ROP
D30W
69.00
7.00
-0.40
Increase
0.63
1ROP
D30Y
69.00
7.00
0.20
Increase
0.83
1ROP
L41A
25.00
6.00
-6.12
Decrease
-2.51
1ROP
L41V
25.00
6.00
-2.53
Decrease
-1.42
1RTB
P93A
56.05
4.20
-2.70
Decrease
-1.60
1RTB
P93G
61.60
6.00
-2.20
Decrease
-2.30
1RTB
P93G
61.80
6.00
-2.60
Decrease
-2.30
1RTB
P93S
56.05
4.20
-2.10
Decrease
-1.95
1RTB
Y97A
63.30
5.00
-12.00
Decrease
-1.62
1RTB
Y97F
63.30
5.00
-3.54
Increase
0.05
1RTB
Y97G
63.30
5.00
-11.70
Decrease
-2.52
1RTB
D121A
25.00
1.20
-0.72
Decrease
-1.18
1RTB
D121A
25.00
6.00
-2.20
Decrease
-1.40
1RTB
D121N
25.00
1.20
-0.76
Decrease
-0.92
1RTB
D121N
25.00
6.00
-1.90
Decrease
-1.19
1RTB
H119A
25.00
1.20
1.10
Decrease
-0.08
1RTB
H119A
25.00
6.00
0.20
Decrease
-0.53
1RTB
P114A
56.05
4.20
-3.20
Decrease
-1.83
1RTB
P114G
56.05
4.20
-2.80
Decrease
-2.17
1RTB
P114G
61.60
6.00
-3.30
Decrease
-2.20
1RTB
P114G
61.80
6.00
-3.60
Decrease
-2.20
1RX4
L28R
15.00
7.80
0.50
Decrease
-3.07
1RX4
V75A
15.00
7.80
-0.20
Decrease
-1.82
1RX4
V75C
15.00
7.80
-0.20
Decrease
-1.42
1RX4
V75H
15.00
6.50
-1.90
Decrease
-2.07
1RX4
V75H
15.00
7.80
-1.70
Decrease
-2.01
1RX4
V75I
15.00
7.80
-2.00
Decrease
-0.08
1RX4
V75R
15.00
7.80
-2.80
Decrease
-0.76
1RX4
V75S
15.00
7.80
-1.90
Decrease
-2.86
1RX4
V75Y
15.00
7.80
-2.30
Decrease
-1.22
1RX4
V88A
20.00
7.20
0.20
Decrease
-0.31
1RX4
V88I
20.00
7.20
-1.73
Decrease
-0.84
1RX4
E139K
15.00
7.80
-2.36
Decrease
-0.86
1RX4
E139Q
15.00
7.80
-1.36
Decrease
-0.65
1SAR
D25K
47.20
7.00
-0.90
Increase
-0.86
1SAR
E74K
47.20
7.00
-1.10
Decrease
-0.49
1SAR
N39A
48.40
7.00
-2.20
Decrease
-1.33
1SAR
N39D
48.40
7.00
-1.50
Increase
-0.99
1SAR
N39S
48.40
7.00
-2.30
Decrease
-1.15
1SHG
F52Y
24.85
7.00
-0.44
Decrease
-1.71
1SHG
K18F
24.85
7.00
2.33
Increase
1.17
1SHG
K59F
24.85
7.00
0.92
Increase
1.20
1SHG
K59F
24.85
7.00
2.51
Increase
1.20
1SHG
K59Y
24.85
7.00
0.84
Increase
0.57
1SHG
Y13F
24.85
7.00
2.53
Decrease
-0.20
1SHG
Y13F
25.00
7.00
0.03
Decrease
-0.19
1SHG
Y57F
24.85
7.00
2.57
Decrease
-0.34
1SHG
Y57F
25.00
7.00
0.07
Decrease
-0.32
1STN
A60G
20.00
7.00
-1.50
Decrease
-2.77
1STN
A60V
20.00
7.00
-2.90
Increase
0.83
1STN
A90S
20.00
7.00
-2.00
Decrease
-0.96
1STN
A90S
47.00
5.00
-2.60
Decrease
-0.59
1STN
A90S
51.40
7.00
-2.50
Decrease
-0.54
1STN
D77A
20.00
7.00
-3.20
Decrease
-2.87
1STN
D77G
20.00
7.00
-2.20
Decrease
-1.75
1STN
D83A
20.00
7.00
-3.90
Decrease
-2.67
1STN
D83G
20.00
7.00
-2.80
Decrease
-2.74
1STN
D95A
20.00
7.00
-3.60
Decrease
-1.71
1STN
D95G
20.00
7.00
-3.10
Decrease
-2.20
1STN
E73A
20.00
7.00
-1.60
Decrease
-0.90
1STN
F61A
20.00
7.00
-2.40
Decrease
-3.05
1STN
F61G
20.00
7.00
-4.70
Decrease
-4.19
1STN
F76A
20.00
7.00
-4.10
Decrease
-3.98
1STN
F76G
20.00
7.00
-4.70
Decrease
-3.98
1STN
G79S
20.00
7.00
-2.40
Decrease
-1.64
1STN
G79S
40.00
5.28
-1.80
Decrease
-1.61
1STN
G79S
47.00
5.00
-1.20
Decrease
-1.58
1STN
G79S
51.40
7.00
-1.30
Decrease
-1.52
1STN
G88V
47.00
5.00
0.60
Decrease
-2.40
1STN
G88V
51.40
7.00
0.50
Decrease
-2.35
1STN
H46Y
40.00
5.38
0.00
Increase
1.85
1STN
I18G
20.00
7.00
-2.60
Decrease
-2.63
1STN
I18M
40.00
5.42
-0.20
Decrease
-0.40
1STN
L25A
47.00
5.00
-2.80
Decrease
-2.87
1STN
L25A
51.40
7.00
-2.60
Decrease
-2.64
1STN
L36A
20.00
7.00
-3.60
Decrease
-2.51
1STN
L36G
20.00
7.00
-5.40
Decrease
-4.07
1STN
L37A
20.00
7.00
-1.80
Decrease
-3.01
1STN
L37G
20.00
7.00
-3.90
Decrease
-4.76
1STN
L89F
40.00
5.38
-1.20
Decrease
-0.32
1STN
T33S
20.00
7.00
-1.40
Decrease
-0.45
1STN
T62A
20.00
7.00
-2.40
Decrease
-1.87
1STN
T62G
20.00
7.00
-3.40
Decrease
-2.33
1STN
V23F
40.00
5.35
-1.50
Decrease
-2.24
1STN
V66L
47.00
5.00
0.60
Decrease
1.03
1STN
V66L
51.40
7.00
0.80
Decrease
0.96
1STN
Y91S
20.00
7.00
-5.30
Decrease
-1.94
1STN
H124L
40.00
5.20
0.70
Increase
1.19
1STN
H124L
47.00
5.00
1.90
Increase
1.26
1STN
H124L
51.40
7.00
1.30
Increase
1.15
1STN
L103A
20.00
7.00
-4.60
Decrease
-3.74
1STN
N118D
20.00
7.00
-2.50
Increase
-0.73
1SUP
M50F
58.80
8.00
0.48
Decrease
-0.27
1SUP
N76D
58.80
8.00
0.45
Decrease
-1.70
1SUP
G169A
58.80
8.00
0.30
Decrease
-1.13
1SUP
N218S
58.80
8.00
1.07
Decrease
-1.73
1SUP
Q206C
58.80
8.00
1.25
Decrease
-0.51
1SUP
Y217K
58.80
8.00
0.72
Decrease
-0.81
1TPK
V65A
64.30
4.50
-2.00
Decrease
-1.43
1TPK
V65I
64.30
4.50
0.30
Decrease
-0.60
1TPK
V65L
64.30
4.50
-1.90
Decrease
-1.53
1TPK
V65M
64.30
4.50
-2.20
Decrease
-1.16
1TPK
V65S
64.30
4.50
-2.40
Decrease
-1.36
1TPK
V65T
64.30
4.50
-1.00
Decrease
-1.22
1TUP
C242S
10.00
7.20
-2.94
Decrease
-1.42
1TUP
R175H
10.00
7.20
-3.01
Decrease
-0.61
1TUP
R248Q
10.00
7.20
-1.94
Decrease
-0.70
1TUP
R249S
10.00
7.20
-1.95
Decrease
-1.91
1TUP
R273H
10.00
7.20
-0.35
Decrease
-2.65
1VQB
I6V
25.00
7.00
-0.70
Decrease
-0.84
1VQB
A86T
25.00
7.00
-0.70
Decrease
-0.69
1VQB
A86V
25.00
7.00
0.50
Decrease
0.38
1VQB
C33A
25.00
7.00
-0.50
Decrease
-1.65
1VQB
C33I
25.00
7.00
-0.90
Decrease
-1.47
1VQB
C33L
25.00
7.00
-2.60
Decrease
-1.83
1VQB
C33M
25.00
7.00
-3.50
Decrease
-0.67
1VQB
C33S
25.00
7.00
-4.20
Decrease
-1.83
1VQB
C33S
25.00
7.00
-4.30
Decrease
-1.83
1VQB
C33T
25.00
7.00
-4.60
Decrease
-2.25
1VQB
C33V
25.00
7.00
-0.20
Decrease
-1.95
1VQB
D36C
25.00
7.00
-2.00
Decrease
-1.13
1VQB
D36C
25.00
7.00
-2.10
Decrease
-1.13
1VQB
D36N
25.00
7.00
-1.00
Decrease
-1.56
1VQB
D50H
25.00
7.00
-1.50
Decrease
0.03
1VQB
D50H
25.00
7.00
-1.60
Decrease
0.03
1VQB
E30F
25.00
7.00
2.00
Decrease
0.13
1VQB
E30F
25.00
7.00
2.10
Decrease
0.13
1VQB
E30M
25.00
7.00
0.60
Increase
-0.04
1VQB
E30M
25.00
7.00
0.70
Increase
-0.04
1VQB
E30N
25.00
7.00
-1.10
Decrease
0.13
1VQB
E40C
25.00
7.00
-1.60
Decrease
-0.88
1VQB
E40T
25.00
7.00
-0.40
Decrease
-0.65
1VQB
F13T
25.00
7.00
-0.70
Decrease
-1.17
1VQB
F68L
25.00
7.00
-4.20
Decrease
-1.73
1VQB
F68L
25.00
7.00
-4.30
Decrease
-1.73
1VQB
F68V
25.00
7.00
-5.00
Decrease
-1.33
1VQB
F73W
25.00
7.00
0.80
Decrease
-1.75
1VQB
H64C
25.00
7.00
0.50
Decrease
-1.18
1VQB
I47A
25.00
7.00
-7.00
Decrease
-3.92
1VQB
I47A
25.00
7.00
-7.10
Decrease
-3.92
1VQB
I47C
25.00
7.00
-5.20
Decrease
-2.74
1VQB
I47C
25.00
7.00
-5.30
Decrease
-2.74
1VQB
I47F
25.00
7.00
-1.90
Decrease
-2.96
1VQB
I47F
25.00
7.00
-2.00
Decrease
-2.96
1VQB
I47L
25.00
7.00
-0.60
Decrease
-2.00
1VQB
I47L
25.00
7.00
-0.70
Decrease
-2.00
1VQB
I47M
25.00
7.00
-2.10
Decrease
-3.13
1VQB
I47M
25.00
7.00
-2.20
Decrease
-3.13
1VQB
I47T
25.00
7.00
-7.40
Decrease
-4.06
1VQB
I47V
25.00
7.00
-2.50
Decrease
-1.08
1VQB
I47V
25.00
7.00
-2.60
Decrease
-1.08
1VQB
I78C
25.00
7.00
-4.40
Decrease
-3.45
1VQB
I78T
25.00
7.00
-6.60
Decrease
-2.80
1VQB
I78V
25.00
7.00
-1.30
Decrease
-0.25
1VQB
K24V
25.00
7.00
0.80
Increase
1.44
1VQB
K69H
25.00
7.00
-1.20
Decrease
-0.39
1VQB
K69H
25.00
7.00
-1.30
Decrease
-0.39
1VQB
K69M
25.00
7.00
0.10
Decrease
-0.56
1VQB
K69M
25.00
7.00
0.20
Decrease
-0.56
1VQB
L28V
25.00
7.00
1.10
Decrease
-1.64
1VQB
L32H
25.00
7.00
-0.90
Decrease
-2.29
1VQB
L32R
25.00
7.00
-1.60
Decrease
-1.46
1VQB
L32W
25.00
7.00
2.80
Decrease
-1.84
1VQB
L32Y
25.00
7.00
1.00
Decrease
-1.38
1VQB
L37A
25.00
7.00
-7.70
Decrease
-3.82
1VQB
L37C
25.00
7.00
-4.60
Decrease
-4.20
1VQB
L37I
25.00
7.00
-1.40
Decrease
-1.35
1VQB
L37T
25.00
7.00
-5.20
Decrease
-4.45
1VQB
L37V
25.00
7.00
-3.50
Decrease
-1.02
1VQB
L49A
25.00
7.00
-6.10
Decrease
-3.78
1VQB
L49C
25.00
7.00
-4.10
Decrease
-4.08
1VQB
L49I
25.00
7.00
-1.90
Decrease
-1.31
1VQB
L49T
25.00
7.00
-5.70
Decrease
-4.57
1VQB
L49V
25.00
7.00
-2.90
Decrease
-1.91
1VQB
L65P
25.00
7.00
-1.50
Decrease
-1.58
1VQB
L81C
25.00
7.00
-3.70
Decrease
-2.42
1VQB
L81T
25.00
7.00
-5.10
Decrease
-3.29
1VQB
L81V
25.00
7.00
-0.20
Decrease
-1.28
1VQB
M77A
25.00
7.00
-2.10
Decrease
-0.96
1VQB
M77C
25.00
7.00
0.00
Decrease
-1.77
1VQB
M77F
25.00
7.00
-0.20
Increase
0.18
1VQB
M77I
25.00
7.00
1.60
Decrease
-1.07
1VQB
M77L
25.00
7.00
-1.20
Decrease
-0.38
1VQB
M77T
25.00
7.00
-0.80
Decrease
-0.74
1VQB
M77V
25.00
7.00
1.20
Decrease
-0.80
1VQB
R82C
25.00
7.00
-1.50
Decrease
-1.07
1VQB
S67C
25.00
7.00
-3.70
Decrease
-1.25
1VQB
S67T
25.00
7.00
-1.60
Decrease
-1.48
1VQB
T48C
25.00
7.00
-0.80
Decrease
-0.43
1VQB
T48V
25.00
7.00
0.00
Decrease
-0.73
1VQB
T62C
25.00
7.00
-0.70
Decrease
-0.98
1VQB
T62V
25.00
7.00
1.30
Decrease
-0.23
1VQB
V19C
25.00
7.00
-0.30
Decrease
-1.86
1VQB
V19T
25.00
7.00
-0.60
Decrease
-2.73
1VQB
V35A
25.00
7.00
-2.20
Decrease
-2.71
1VQB
V35A
25.00
7.00
-2.20
Decrease
-2.71
1VQB
V35C
25.00
7.00
-1.40
Decrease
-2.08
1VQB
V35C
25.00
7.00
-1.40
Decrease
-2.08
1VQB
V35F
25.00
7.00
-3.10
Decrease
-1.70
1VQB
V35F
25.00
7.00
-3.20
Decrease
-1.70
1VQB
V35I
25.00
7.00
-0.60
Decrease
-0.29
1VQB
V35I
25.00
7.00
-0.70
Decrease
-0.29
1VQB
V35L
25.00
7.00
-2.70
Decrease
-2.22
1VQB
V35L
25.00
7.00
-2.70
Decrease
-2.22
1VQB
V35M
25.00
7.00
-1.00
Decrease
-3.25
1VQB
V35M
25.00
7.00
-1.10
Decrease
-3.25
1VQB
V35T
25.00
7.00
-5.30
Decrease
-3.01
1VQB
V43C
25.00
7.00
-2.10
Decrease
-1.85
1VQB
V43T
25.00
7.00
-1.60
Decrease
-3.80
1VQB
V45A
25.00
7.00
-2.10
Decrease
-2.39
1VQB
V45C
25.00
7.00
-0.10
Decrease
-2.01
1VQB
V45L
25.00
7.00
-3.00
Decrease
-1.62
1VQB
V45T
25.00
7.00
-3.50
Decrease
-1.99
1VQB
V63C
25.00
7.00
-4.10
Decrease
-2.42
1VQB
V63T
25.00
7.00
-5.00
Decrease
-3.35
1VQB
V70C
25.00
7.00
-3.10
Decrease
-3.03
1VQB
V70C
25.00
7.00
-3.30
Decrease
-3.03
1VQB
V70P
25.00
7.00
-5.00
Decrease
-2.78
1VQB
V70P
25.00
7.00
-5.10
Decrease
-2.78
1VQB
V70T
25.00
7.00
-3.50
Decrease
-2.99
1VQB
Y26R
25.00
7.00
-0.40
Decrease
-1.26
1VQB
Y41A
25.00
7.00
-0.40
Decrease
-2.30
1VQB
Y41F
25.00
7.00
-0.60
Decrease
0.65
1YCC
F82Y
25.00
6.00
-0.70
Decrease
-0.80
1YCC
K73I
25.00
4.50
-0.40
Decrease
0.33
1YCC
K73V
25.00
4.50
0.10
Increase
0.27
1YCC
K73W
25.00
4.50
-1.60
Decrease
-1.43
1YCC
L85A
25.00
6.00
-2.80
Decrease
-2.97
1YCC
N52A
26.85
4.60
0.63
Decrease
-0.76
1YCC
N52H
26.85
4.60
-1.27
Decrease
-1.08
1YCC
N52I
26.85
3.50
2.62
Increase
2.81
1YCC
N52I
26.85
4.00
3.03
Increase
2.79
1YCC
N52I
26.85
4.60
3.14
Increase
2.76
1YCC
N52I
26.85
5.00
2.02
Increase
2.74
1YCC
N52I
37.00
4.60
3.14
Increase
2.97
1YCC
N52I
46.50
6.00
4.30
Increase
3.03
1YCC
N52L
26.85
4.60
2.56
Increase
2.39
1YCC
N52M
26.85
4.00
2.91
Increase
2.44
1YCC
N52M
26.85
4.60
2.25
Increase
2.42
1YCC
N52Q
26.85
4.60
-0.08
Decrease
0.09
1YCC
N52S
26.85
4.00
0.74
Decrease
0.14
1YCC
N52S
26.85
4.60
-0.05
Decrease
0.13
1YCC
N52S
26.85
5.00
-1.29
Decrease
0.11
1YCC
N52T
26.85
3.50
0.98
Increase
0.81
1YCC
N52T
26.85
4.00
1.01
Increase
0.76
1YCC
N52T
26.85
4.60
0.59
Increase
0.69
1YCC
N52T
26.85
5.00
-0.53
Increase
0.64
1YCC
N52V
26.85
4.00
2.44
Increase
1.87
1YCC
N52V
26.85
4.60
1.67
Increase
1.84
1YCC
P76G
25.00
4.60
-0.78
Decrease
-0.95
1YCC
P76L
25.00
4.60
-3.44
Decrease
-0.97
1YCC
P76R
25.00
4.60
-0.97
Decrease
-1.15
1YCC
P76S
25.00
4.60
-1.89
Decrease
-2.06
1YCC
P76V
25.00
4.60
-1.07
Decrease
-1.13
1YCC
P76W
25.00
4.60
-2.38
Decrease
-2.21
1YCC
P76Y
25.00
4.60
-2.07
Decrease
-1.90
1YCC
C102A
46.50
6.00
2.90
Decrease
2.56
1YCC
C102S
46.50
6.00
2.80
Increase
1.43
1YCC
C102T
51.40
4.70
0.50
Increase
1.77
1YCC
C102T
51.40
4.70
5.30
Increase
1.77
1YCC
C102T
57.10
6.00
0.80
Increase
1.77
1YCC
C102T
57.10
6.00
5.70
Increase
1.77
2ABD
A9G
5.00
5.30
-1.81
Decrease
-1.80
2ABD
F5A
5.00
5.30
-2.52
Decrease
-1.64
2ABD
A34G
5.00
5.30
-1.57
Decrease
-1.50
2ABD
D21A
5.00
5.30
0.42
Decrease
-0.59
2ABD
D21H
5.00
5.30
-0.56
Decrease
-0.29
2ABD
E67A
5.00
5.30
-0.36
Decrease
-1.45
2ABD
K32A
5.00
5.30
-1.02
Decrease
-0.98
2ABD
K32E
5.00
5.30
-1.68
Decrease
-0.71
2ABD
K32R
5.00
5.30
-1.83
Decrease
-0.16
2ABD
K52M
5.00
5.30
0.18
Increase
-0.36
2ABD
K54A
5.00
5.30
-0.86
Increase
0.60
2ABD
K54M
5.00
5.30
0.27
Increase
0.28
2ABD
L15A
5.00
5.30
-3.10
Decrease
-3.02
2ABD
L25A
5.00
5.30
-1.02
Decrease
-3.42
2ABD
L80A
5.00
5.30
-3.70
Decrease
-1.95
2ABD
P19A
5.00
5.30
-1.07
Decrease
-1.02
2ABD
P44A
5.00
5.30
-1.40
Decrease
-2.69
2ABD
Q33A
5.00
5.30
-3.66
Decrease
-0.04
2ABD
T35A
5.00
5.30
-1.09
Decrease
-2.15
2ABD
V12A
5.00
5.30
-1.69
Decrease
-0.18
2ABD
V77A
5.00
5.30
-1.14
Decrease
-1.37
2ABD
Y28A
5.00
5.30
-2.47
Decrease
-3.42
2ABD
Y28F
5.00
5.30
-1.06
Increase
0.26
2ABD
Y28N
5.00
5.30
-2.23
Decrease
-1.25
2ABD
Y31N
5.00
5.30
-1.52
Decrease
-2.47
2ABD
Y73A
5.00
5.30
-4.83
Decrease
-2.10
2ABD
Y73F
5.00
5.30
0.27
Increase
-0.53
2AFG
L44P
40.05
6.60
0.69
Decrease
-1.60
2AFG
L73V
40.05
6.60
-1.46
Decrease
-1.58
2AFG
V109L
40.05
6.60
-0.57
Increase
-0.52
2AKY
V8I
25.00
7.50
-1.20
Decrease
-0.48
2AKY
T77H
25.00
7.50
-2.15
Decrease
-1.36
2AKY
I213F
25.00
7.50
-1.91
Decrease
-0.92
2AKY
N169D
25.00
7.50
-2.15
Decrease
-1.21
2CI2
A35G
25.00
6.25
-1.09
Decrease
-1.35
2CI2
A77G
25.00
6.30
-1.88
Decrease
-1.05
2CI2
D42A
25.00
6.25
-0.96
Decrease
0.17
2CI2
D64A
25.00
6.25
-0.80
Decrease
-2.14
2CI2
D71A
25.00
6.25
-3.41
Decrease
-1.92
2CI2
E26A
25.00
6.25
-0.47
Decrease
-0.84
2CI2
E26Q
25.00
6.25
-0.62
Decrease
-0.22
2CI2
E33D
25.00
6.25
-0.52
Decrease
-0.48
2CI2
E33N
25.00
6.25
-0.70
Decrease
-1.08
2CI2
E33N
46.45
6.30
-0.70
Decrease
-0.98
2CI2
E33Q
25.00
6.25
-0.29
Decrease
-0.54
2CI2
E34D
25.00
6.25
-0.74
Decrease
-0.41
2CI2
E34N
25.00
6.25
-1.07
Decrease
-0.55
2CI2
E34Q
25.00
6.25
-0.47
Decrease
-0.57
2CI2
E45A
25.00
6.25
-0.32
Decrease
-0.36
2CI2
E45A
74.30
4.15
0.82
Decrease
0.57
2CI2
E60A
25.00
6.25
-0.70
Decrease
-0.97
2CI2
E60A
25.00
6.30
-0.68
Decrease
-0.97
2CI2
F69A
25.00
6.25
-3.84
Decrease
-2.98
2CI2
F69L
25.00
6.25
-2.11
Decrease
-1.97
2CI2
F69L
46.45
6.30
-2.11
Decrease
-1.61
2CI2
F69V
25.00
6.25
-2.39
Decrease
-2.82
2CI2
I39V
25.00
3.00
-1.20
Decrease
-1.33
2CI2
I39V
25.00
3.50
-1.16
Decrease
-1.35
2CI2
I39V
25.00
6.25
-1.30
Decrease
-1.45
2CI2
I39V
25.00
6.30
-1.27
Decrease
-1.45
2CI2
I39V
46.45
6.30
-1.30
Decrease
-1.13
2CI2
I48A
25.00
3.50
-3.89
Decrease
-2.01
2CI2
I48A
25.00
6.30
-3.84
Decrease
-2.03
2CI2
I48V
25.00
3.50
-0.92
Decrease
-0.36
2CI2
I48V
25.00
6.30
-1.09
Decrease
-0.42
2CI2
I48V
46.45
6.30
-1.11
Decrease
-0.19
2CI2
I49A
25.00
6.30
-2.12
Decrease
-3.75
2CI2
I49A
46.45
6.30
-2.12
Decrease
-3.32
2CI2
I49G
25.00
6.30
-3.52
Decrease
-2.52
2CI2
I49T
25.00
6.30
-1.34
Decrease
-2.67
2CI2
I49V
25.00
6.30
0.08
Decrease
-1.06
2CI2
I49V
46.45
6.30
0.08
Decrease
-0.79
2CI2
I56A
25.00
6.25
-0.03
Decrease
-2.70
2CI2
I76A
25.00
3.00
-4.23
Decrease
-2.86
2CI2
I76A
25.00
3.50
-4.34
Decrease
-2.88
2CI2
I76A
25.00
6.30
-4.25
Decrease
-2.89
2CI2
I76V
25.00
3.00
0.09
Decrease
-1.94
2CI2
I76V
25.00
6.30
0.21
Decrease
-1.98
2CI2
I76V
46.45
6.30
0.19
Decrease
-1.75
2CI2
K21A
25.00
6.25
-0.55
Decrease
-0.73
2CI2
K21M
25.00
6.25
-0.67
Increase
0.15
2CI2
K30A
25.00
6.25
0.42
Decrease
-0.11
2CI2
K36A
25.00
6.25
-0.49
Decrease
-0.04
2CI2
K36A
46.45
6.30
-0.49
Decrease
0.20
2CI2
K36G
25.00
6.25
-2.32
Decrease
-0.70
2CI2
K37A
25.00
6.25
0.21
Decrease
-0.61
2CI2
K37A
46.45
6.30
0.23
Decrease
-0.46
2CI2
K37G
25.00
6.25
-0.99
Decrease
-1.80
2CI2
K37G
46.45
6.30
-0.97
Decrease
-1.62
2CI2
K43A
25.00
6.25
-0.65
Decrease
-0.49
2CI2
K43A
46.45
6.30
-0.65
Decrease
-0.37
2CI2
K43A
74.30
4.15
0.26
Decrease
-0.16
2CI2
K43G
25.00
6.25
-3.19
Decrease
0.06
2CI2
K72N
25.00
6.25
0.00
Decrease
-1.25
2CI2
L27A
25.00
3.00
-2.66
Decrease
-2.58
2CI2
L27A
25.00
6.30
-2.64
Decrease
-2.42
2CI2
L27A
46.45
6.30
-2.68
Decrease
-2.06
2CI2
L40A
25.00
6.25
-1.33
Decrease
-2.40
2CI2
L40G
25.00
6.25
-1.38
Decrease
-3.60
2CI2
L51A
25.00
6.25
-2.37
Decrease
-2.36
2CI2
L51A
46.45
6.30
-2.37
Decrease
-2.13
2CI2
L51I
25.00
6.25
-0.26
Decrease
-0.86
2CI2
L51V
25.00
6.25
-0.50
Decrease
-1.57
2CI2
L51V
46.45
6.30
-0.50
Decrease
-1.47
2CI2
L68A
25.00
3.50
-3.74
Decrease
-5.43
2CI2
L68A
25.00
6.30
-3.82
Decrease
-5.35
2CI2
N75A
25.00
6.25
-0.83
Decrease
-2.40
2CI2
N75D
25.00
6.25
-1.21
Decrease
-0.84
2CI2
P25A
25.00
6.25
-1.57
Decrease
-0.91
2CI2
P44A
25.00
6.25
-1.76
Decrease
-0.45
2CI2
P44A
74.30
4.15
1.82
Decrease
0.04
2CI2
P52A
25.00
6.25
-0.17
Decrease
-1.16
2CI2
P80A
25.00
6.25
-3.34
Decrease
-1.70
2CI2
Q41A
25.00
6.25
-0.02
Decrease
-0.08
2CI2
Q41G
25.00
6.25
-0.60
Decrease
-0.63
2CI2
R62A
25.00
6.25
-0.58
Decrease
-0.58
2CI2
S31A
25.00
3.00
1.00
Decrease
0.53
2CI2
S31A
25.00
6.25
-0.89
Decrease
0.33
2CI2
S31A
46.45
6.30
-0.89
Decrease
0.71
2CI2
S31G
25.00
3.50
0.84
Decrease
-1.20
2CI2
S31G
25.00
6.25
-0.80
Decrease
-1.41
2CI2
T22A
25.00
6.30
-0.85
Decrease
-1.41
2CI2
T22A
46.45
6.30
-0.85
Decrease
-1.08
2CI2
T22G
25.00
6.30
-1.16
Decrease
-1.39
2CI2
T22V
25.00
6.30
-0.32
Decrease
-0.32
2CI2
T55A
25.00
6.25
0.23
Decrease
-0.87
2CI2
T55S
25.00
6.25
-0.02
Decrease
-0.29
2CI2
T55V
25.00
6.25
-0.76
Decrease
-0.30
2CI2
T58A
25.00
6.30
-0.69
Decrease
-0.52
2CI2
T58D
25.00
6.30
0.04
Decrease
-0.01
2CI2
V38A
25.00
3.00
-0.46
Decrease
-0.98
2CI2
V38A
25.00
6.25
-0.49
Decrease
-1.05
2CI2
V38A
25.00
6.30
-0.46
Decrease
-1.05
2CI2
V38A
46.45
6.30
-0.48
Decrease
-0.78
2CI2
V53A
25.00
6.30
-0.64
Decrease
-1.30
2CI2
V53A
46.45
6.30
-0.63
Decrease
-1.32
2CI2
V53G
25.00
6.30
-2.43
Decrease
-3.70
2CI2
V53T
25.00
6.30
-1.03
Decrease
-1.57
2CI2
V53T
46.45
6.30
-1.03
Decrease
-1.57
2CI2
V57A
25.00
6.25
-1.47
Decrease
-1.02
2CI2
V66A
25.00
3.50
-4.91
Decrease
-2.20
2CI2
V66A
25.00
6.30
-4.88
Decrease
-2.29
2CI2
V70A
25.00
3.00
-2.17
Decrease
-2.96
2CI2
V70A
25.00
6.30
-1.95
Decrease
-3.15
2CI2
V70A
46.45
6.30
-1.95
Decrease
-2.96
2CI2
V79A
25.00
6.30
-1.51
Decrease
-2.02
2CI2
V79G
25.00
6.30
-3.24
Decrease
-3.43
2CI2
V79T
25.00
6.30
-0.38
Decrease
-1.45
2CI2
V82A
25.00
6.30
-1.45
Decrease
-1.23
2CI2
V82G
25.00
6.30
-3.50
Decrease
-2.78
2CI2
V82T
25.00
6.30
-1.15
Decrease
-1.49
2HPR
G49A
25.00
7.00
0.80
Decrease
-0.81
2HPR
G49E
25.00
7.00
1.40
Increase
-0.85
2HPR
G49K
25.00
7.00
-1.00
Decrease
-1.63
2LZM
I3A
41.90
2.00
-1.10
Decrease
-1.96
2LZM
I3A
64.70
6.50
-0.70
Decrease
-1.80
2LZM
I3C
41.90
2.00
1.00
Decrease
-2.77
2LZM
I3C
41.90
2.00
-0.40
Decrease
-2.77
2LZM
I3C
64.70
6.50
1.20
Decrease
-2.73
2LZM
I3C
64.70
6.50
-1.20
Decrease
-2.73
2LZM
I3D
41.90
2.00
-1.80
Decrease
-1.82
2LZM
I3D
64.70
6.50
-3.20
Decrease
-2.04
2LZM
I3E
38.75
2.00
-1.77
Decrease
-1.39
2LZM
I3E
41.90
2.00
-1.10
Decrease
-1.39
2LZM
I3E
46.16
2.50
-1.71
Decrease
-1.41
2LZM
I3E
53.56
3.00
-1.53
Decrease
-1.44
2LZM
I3E
64.70
6.50
-2.00
Decrease
-1.58
2LZM
I3F
38.75
2.00
-1.49
Decrease
0.07
2LZM
I3F
41.90
2.00
-1.00
Decrease
0.07
2LZM
I3F
46.16
2.50
-1.09
Decrease
0.04
2LZM
I3F
53.56
3.00
-0.53
Decrease
-0.01
2LZM
I3F
64.70
6.50
-1.10
Decrease
-0.15
2LZM
I3G
41.90
2.00
-1.80
Decrease
-3.25
2LZM
I3G
64.70
6.50
-2.10
Decrease
-3.42
2LZM
I3L
38.75
2.00
0.85
Decrease
0.21
2LZM
I3L
41.90
2.00
0.90
Decrease
0.22
2LZM
I3L
46.16
2.50
1.01
Decrease
0.22
2LZM
I3L
53.42
3.00
0.83
Decrease
0.22
2LZM
I3L
53.56
3.00
1.16
Decrease
0.22
2LZM
I3L
64.70
6.50
0.40
Decrease
0.20
2LZM
I3L
66.51
5.40
0.70
Decrease
0.20
2LZM
I3M
41.90
2.00
-0.30
Decrease
-0.19
2LZM
I3M
64.70
6.50
-0.90
Decrease
-0.10
2LZM
I3P
38.75
2.00
-2.96
Decrease
-2.35
2LZM
I3P
46.16
2.50
-2.97
Decrease
-2.35
2LZM
I3P
53.56
3.00
-2.53
Decrease
-2.36
2LZM
I3S
41.90
2.00
-1.90
Decrease
-1.68
2LZM
I3S
64.70
6.50
-1.70
Decrease
-1.59
2LZM
I3T
38.75
2.00
-2.45
Decrease
-2.05
2LZM
I3T
41.90
2.00
-1.70
Decrease
-2.04
2LZM
I3T
46.16
2.50
-2.28
Decrease
-2.06
2LZM
I3T
53.56
3.00
-1.81
Decrease
-2.09
2LZM
I3T
64.70
6.50
-2.30
Decrease
-2.26
2LZM
I3V
41.90
2.00
-0.60
Decrease
-0.20
2LZM
I3V
64.70
6.50
-0.40
Decrease
-0.22
2LZM
I3W
64.70
6.50
-2.80
Decrease
-1.06
2LZM
I3Y
41.90
2.00
-2.70
Decrease
-2.28
2LZM
I3Y
64.70
6.50
-2.30
Decrease
-2.63
2LZM
L7A
51.65
3.00
-2.60
Decrease
-2.22
2LZM
M6A
51.65
3.00
-1.90
Decrease
-1.13
2LZM
M6I
65.50
6.00
-1.38
Decrease
-1.14
2LZM
M6L
47.00
3.00
-2.80
Decrease
-1.04
2LZM
A41D
65.15
5.40
0.29
Decrease
-1.01
2LZM
A41S
51.55
3.00
-0.60
Decrease
-0.64
2LZM
A41V
41.47
2.03
0.42
Increase
0.35
2LZM
A41V
51.10
2.83
0.45
Increase
0.43
2LZM
A41V
53.42
3.00
0.41
Increase
0.44
2LZM
A41V
66.51
5.40
0.30
Increase
0.47
2LZM
A42K
53.00
5.45
-3.70
Decrease
-0.61
2LZM
A42S
51.55
3.00
-2.30
Decrease
-0.43
2LZM
A49S
51.55
3.00
-0.50
Decrease
-0.27
2LZM
A73S
51.55
3.00
-0.40
Decrease
-1.36
2LZM
A74P
57.50
3.50
-5.70
Increase
-0.31
2LZM
A74P
62.20
4.00
-5.00
Increase
-0.26
2LZM
A74P
62.90
6.50
-4.60
Increase
-0.34
2LZM
A74P
65.70
5.50
-4.50
Increase
-0.27
2LZM
A82P
38.80
2.00
-0.07
Increase
-1.55
2LZM
A82P
41.90
2.00
0.30
Increase
-1.54
2LZM
A82P
41.90
2.00
0.30
Increase
-1.54
2LZM
A82P
46.20
2.50
0.51
Increase
-1.56
2LZM
A82P
53.42
3.00
0.45
Increase
-1.59
2LZM
A82P
53.60
3.00
1.27
Increase
-1.59
2LZM
A82P
64.70
6.50
0.80
Decrease
-1.83
2LZM
A82P
64.70
6.50
0.80
Decrease
-1.83
2LZM
A82P
66.51
5.40
0.57
Decrease
-1.75
2LZM
A82S
51.55
3.00
-0.30
Decrease
-0.27
2LZM
A93P
38.80
2.00
0.03
Increase
-0.18
2LZM
A93P
41.90
2.00
0.10
Increase
-0.15
2LZM
A93P
46.20
2.50
0.51
Increase
-0.12
2LZM
A93P
53.60
3.00
1.10
Increase
-0.08
2LZM
A93P
64.70
6.50
0.10
Increase
-0.11
2LZM
A93S
51.55
3.00
-0.20
Decrease
-0.73
2LZM
A93T
65.15
5.40
0.06
Decrease
-1.00
2LZM
A98S
51.55
3.00
-2.50
Decrease
-0.86
2LZM
A98V
40.00
3.00
-4.90
Increase
-0.50
2LZM
C54T
65.50
6.00
1.36
Increase
-1.20
2LZM
C54T
70.00
6.50
0.30
Increase
-1.17
2LZM
C54V
70.00
6.50
-0.70
Decrease
-0.14
2LZM
D20A
65.10
5.40
-0.30
Increase
0.56
2LZM
D20N
65.10
5.40
1.30
Decrease
-0.89
2LZM
D20S
65.10
5.40
0.70
Increase
0.84
2LZM
D20T
65.10
5.40
0.90
Increase
0.45
2LZM
D47A
51.65
3.00
-0.28
Decrease
-0.52
2LZM
D47A
62.20
6.70
-0.95
Increase
0.07
2LZM
D72P
38.50
2.00
-2.60
Decrease
-2.96
2LZM
D72P
63.40
6.50
-2.70
Decrease
-2.38
2LZM
D92N
39.50
2.00
-0.10
Decrease
-1.48
2LZM
D92N
62.40
6.70
-1.40
Decrease
-0.90
2LZM
E11A
66.48
5.40
1.10
Increase
0.57
2LZM
E11F
66.48
5.40
1.70
Increase
1.53
2LZM
E11H
65.10
5.40
0.10
Increase
-0.65
2LZM
E11M
66.48
5.40
1.60
Increase
1.67
2LZM
E11N
65.10
5.40
-0.10
Increase
-0.47
2LZM
E22K
65.15
5.40
0.57
Decrease
-1.14
2LZM
E45A
51.65
3.00
0.55
Decrease
-0.21
2LZM
E45A
62.20
6.70
0.01
Decrease
0.10
2LZM
F67A
51.65
3.00
-1.90
Decrease
-2.04
2LZM
G30A
66.48
5.40
0.10
Decrease
-1.05
2LZM
G30F
66.48
5.40
-1.50
Increase
-0.35
2LZM
G77A
41.90
2.00
-0.40
Decrease
-2.60
2LZM
G77A
41.90
2.00
-0.40
Decrease
-2.60
2LZM
G77A
64.70
6.50
0.40
Decrease
-2.24
2LZM
G77A
64.70
6.50
0.40
Decrease
-2.24
2LZM
H31N
66.00
5.50
-4.00
Decrease
-1.59
2LZM
I17A
51.65
3.00
-2.70
Decrease
-2.43
2LZM
I27A
51.65
3.00
-3.10
Decrease
-2.23
2LZM
I29A
51.65
3.00
-2.60
Decrease
-3.13
2LZM
I50A
51.65
3.00
-2.00
Decrease
-2.79
2LZM
I58A
51.65
3.00
-3.20
Decrease
-2.26
2LZM
I58T
59.00
5.40
-3.40
Decrease
-1.17
2LZM
I78A
51.65
3.00
-1.60
Decrease
-2.79
2LZM
I78M
65.30
5.42
-1.50
Decrease
-0.84
2LZM
K16E
50.90
2.80
-0.50
Decrease
-0.07
2LZM
K16E
66.70
5.30
0.50
Decrease
-0.16
2LZM
K43A
51.65
3.00
-0.96
Decrease
0.43
2LZM
K43A
53.00
5.45
-1.10
Decrease
0.41
2LZM
K43A
62.20
6.70
-1.03
Decrease
0.44
2LZM
K48A
51.65
3.00
-0.32
Decrease
-0.16
2LZM
K48A
62.20
6.70
-0.56
Decrease
-0.15
2LZM
K60H
28.50
2.00
-0.80
Decrease
-0.71
2LZM
K60H
63.00
6.50
-0.10
Decrease
-0.34
2LZM
K60P
41.90
2.00
0.10
Decrease
-1.77
2LZM
K60P
64.70
6.50
0.00
Decrease
-1.84
2LZM
K83H
28.50
2.00
-0.50
Decrease
-1.27
2LZM
K83H
63.00
6.50
-0.40
Decrease
-1.05
2LZM
L33A
51.65
3.00
-3.60
Decrease
-2.61
2LZM
L39A
53.00
5.45
-0.90
Decrease
-1.76
2LZM
L46A
51.65
3.00
-2.62
Decrease
-3.04
2LZM
L46A
51.80
3.01
-2.70
Decrease
-3.04
2LZM
L46A
53.00
5.45
-2.10
Decrease
-2.95
2LZM
L46A
62.20
6.70
-1.86
Decrease
-2.77
2LZM
L66A
51.65
3.00
-3.90
Decrease
-3.54
2LZM
L84A
51.65
3.00
-3.90
Decrease
-3.83
2LZM
L84M
65.30
5.42
-1.90
Decrease
-1.02
2LZM
L91A
51.65
3.00
-3.10
Decrease
-3.54
2LZM
L91M
65.30
5.42
-0.80
Decrease
-1.34
2LZM
L99A
51.70
3.00
-4.60
Decrease
-3.57
2LZM
L99A
51.76
3.01
-5.00
Decrease
-3.57
2LZM
L99A
51.80
3.01
-5.00
Decrease
-3.57
2LZM
L99A
64.88
5.70
-4.50
Decrease
-3.21
2LZM
L99A
65.20
5.40
-4.00
Decrease
-3.21
2LZM
L99F
51.76
3.01
-0.40
Decrease
-1.99
2LZM
L99F
64.88
5.70
-0.30
Decrease
-1.97
2LZM
L99G
51.70
3.00
-7.40
Decrease
-4.55
2LZM
L99G
65.20
5.40
-6.30
Decrease
-4.53
2LZM
L99I
51.76
3.01
-1.40
Decrease
-2.13
2LZM
L99I
64.88
5.70
-1.50
Decrease
-1.95
2LZM
L99M
51.76
3.01
-0.70
Decrease
-1.33
2LZM
L99M
64.88
5.70
-0.60
Decrease
-1.27
2LZM
L99M
65.30
5.42
-0.40
Decrease
-1.28
2LZM
L99V
51.76
3.01
-2.30
Decrease
-2.17
2LZM
L99V
64.88
5.70
-2.00
Decrease
-2.09
2LZM
N40A
51.65
3.00
0.43
Decrease
0.14
2LZM
N40A
53.00
5.45
0.20
Decrease
0.03
2LZM
N40A
62.20
6.70
0.32
Decrease
0.12
2LZM
N40D
65.15
5.40
0.44
Increase
-0.45
2LZM
N55G
41.90
2.00
-0.50
Decrease
-2.10
2LZM
N55G
64.70
6.50
-0.60
Decrease
-1.66
2LZM
N68A
47.80
2.50
-0.05
Decrease
-0.68
2LZM
Q69P
38.50
2.00
-3.30
Decrease
-1.05
2LZM
Q69P
63.20
6.50
-2.90
Decrease
-1.13
2LZM
R14K
65.15
5.40
-0.03
Decrease
-1.72
2LZM
R80K
65.15
5.40
-0.17
Decrease
-1.87
2LZM
R96H
65.50
6.00
-2.82
Decrease
-1.00
2LZM
R96H
70.00
6.50
-2.80
Decrease
-0.96
2LZM
S38D
40.90
2.00
-0.10
Increase
0.43
2LZM
S38D
53.42
3.00
0.22
Increase
0.34
2LZM
S38D
66.10
6.90
0.60
Increase
-0.01
2LZM
S38D
66.51
5.40
0.60
Increase
0.11
2LZM
S38N
39.50
2.00
-0.10
Increase
-0.67
2LZM
S38N
62.40
6.70
0.00
Increase
-0.65
2LZM
S44A
47.80
2.50
-0.44
Decrease
-0.14
2LZM
S44A
51.65
3.00
0.44
Decrease
-0.11
2LZM
S44A
51.68
3.01
0.43
Decrease
-0.11
2LZM
S44A
62.20
6.70
0.34
Decrease
-0.16
2LZM
S44C
51.68
3.01
-0.11
Increase
-0.27
2LZM
S44D
51.68
3.01
-0.11
Increase
0.21
2LZM
S44E
51.68
3.01
0.00
Increase
0.41
2LZM
S44F
51.68
3.01
0.06
Increase
0.01
2LZM
S44G
51.68
3.01
-0.53
Increase
-0.99
2LZM
S44H
51.68
3.01
0.04
Decrease
-0.82
2LZM
S44I
51.68
3.01
0.31
Increase
0.46
2LZM
S44K
51.68
3.01
0.20
Increase
-1.23
2LZM
S44L
51.68
3.01
0.39
Increase
-0.07
2LZM
S44M
51.68
3.01
0.33
Increase
0.12
2LZM
S44N
51.68
3.01
-0.14
Increase
0.22
2LZM
S44P
51.68
3.01
-3.03
Increase
-0.05
2LZM
S44Q
51.68
3.01
0.27
Increase
-0.09
2LZM
S44R
51.68
3.01
0.24
Increase
-0.22
2LZM
S44T
51.68
3.01
0.01
Increase
1.29
2LZM
S44V
51.68
3.01
0.10
Increase
0.80
2LZM
S44W
51.68
3.01
0.05
Increase
0.18
2LZM
S44Y
51.68
3.01
0.19
Increase
-1.46
2LZM
S90H
28.50
2.00
-1.00
Increase
-0.45
2LZM
S90H
63.00
6.50
-1.10
Increase
-0.01
2LZM
S90H
65.40
5.50
-1.10
Increase
-0.03
2LZM
T26S
65.15
5.40
0.57
Increase
-0.91
2LZM
T59A
41.00
2.00
-2.80
Decrease
-1.92
2LZM
T59A
63.00
6.50
-1.50
Decrease
-1.67
2LZM
T59D
41.00
2.00
-0.90
Decrease
-1.14
2LZM
T59D
63.00
6.50
-1.20
Decrease
-0.73
2LZM
T59G
41.00
2.00
-2.20
Decrease
-1.52
2LZM
T59G
63.00
6.50
-1.60
Decrease
-1.39
2LZM
T59N
41.00
2.00
-0.60
Decrease
-1.70
2LZM
T59N
63.00
6.50
-1.10
Decrease
-1.40
2LZM
T59S
41.00
2.00
-0.70
Decrease
-1.15
2LZM
T59S
63.00
6.50
-0.20
Decrease
-0.59
2LZM
T59V
41.00
2.00
-2.80
Decrease
-2.10
2LZM
T59V
63.00
6.50
-1.50
Decrease
-1.56
2LZM
V71A
51.65
3.00
-1.50
Decrease
-1.34
2LZM
V75T
51.55
3.00
-1.30
Decrease
-1.57
2LZM
V87A
51.65
3.00
-1.70
Decrease
-2.01
2LZM
V87T
51.55
3.00
-1.60
Decrease
-1.28
2LZM
V94A
51.65
3.00
-1.80
Decrease
-2.04
2LZM
A129L
65.30
5.40
-1.30
Decrease
-0.24
2LZM
A129M
65.30
5.40
-1.90
Decrease
-0.48
2LZM
A129V
41.40
1.99
-0.80
Increase
-0.34
2LZM
A129V
52.10
2.80
-0.70
Increase
-0.27
2LZM
A130S
51.55
3.00
-1.00
Decrease
-0.12
2LZM
A134S
51.55
3.00
-0.10
Decrease
-0.97
2LZM
A146T
47.00
3.00
-2.29
Increase
-0.12
2LZM
A146T
70.00
6.50
-1.50
Increase
-0.48
2LZM
A160T
65.50
6.00
-1.65
Decrease
0.07
2LZM
E108V
51.70
3.00
1.20
Decrease
-0.80
2LZM
E108V
65.20
5.40
0.70
Decrease
-0.56
2LZM
E128A
40.75
2.02
0.16
Decrease
0.18
2LZM
E128A
40.80
2.00
0.16
Decrease
0.18
2LZM
E128K
47.00
3.00
-1.16
Decrease
-1.50
2LZM
F104A
51.65
3.00
-3.10
Decrease
-2.15
2LZM
F153A
51.76
3.01
-3.50
Decrease
-2.70
2LZM
F153A
51.80
3.01
-3.50
Decrease
-2.70
2LZM
F153A
64.88
5.70
-3.80
Decrease
-2.47
2LZM
F153A
65.30
5.40
-3.40
Decrease
-2.44
2LZM
F153I
51.76
3.01
-0.50
Decrease
-1.14
2LZM
F153I
64.88
5.70
-0.20
Decrease
-0.91
2LZM
F153L
51.76
3.01
0.20
Decrease
-1.84
2LZM
F153L
64.88
5.70
0.30
Decrease
-1.72
2LZM
F153L
65.15
5.40
0.35
Decrease
-1.69
2LZM
F153M
51.76
3.01
-0.80
Decrease
-1.26
2LZM
F153M
64.88
5.70
-0.60
Decrease
-1.17
2LZM
F153M
65.30
5.42
-0.60
Decrease
-1.16
2LZM
F153V
51.76
3.01
-1.80
Decrease
-0.78
2LZM
F153V
64.88
5.70
-1.80
Decrease
-0.64
2LZM
G113A
38.80
2.00
0.50
Decrease
-0.18
2LZM
G113A
41.90
2.00
0.10
Decrease
-0.12
2LZM
G113A
46.20
2.50
0.54
Decrease
-0.02
2LZM
G113A
53.60
3.00
0.54
Decrease
0.13
2LZM
G113A
64.70
6.50
0.30
Decrease
0.45
2LZM
G113E
65.15
5.40
0.30
Increase
0.45
2LZM
G156D
41.90
2.00
-1.40
Decrease
-2.11
2LZM
G156D
64.70
6.50
-2.30
Decrease
-1.97
2LZM
I100A
51.65
3.00
-3.40
Decrease
-2.89
2LZM
I100M
65.30
5.42
-1.60
Decrease
-1.74
2LZM
K124G
41.90
2.00
0.00
Decrease
0.22
2LZM
K124G
64.70
6.50
-0.10
Decrease
0.00
2LZM
K135E
25.00
5.30
-1.00
Increase
-0.23
2LZM
K135E
50.90
2.80
-0.20
Increase
-0.06
2LZM
K135E
66.70
5.30
-1.00
Increase
-0.07
2LZM
K147E
25.00
5.30
-0.70
Decrease
-0.25
2LZM
K147E
50.90
2.80
0.10
Decrease
-0.15
2LZM
K147E
66.70
5.30
-0.70
Decrease
-0.12
2LZM
L118A
51.65
3.01
-3.50
Decrease
-3.18
2LZM
L118A
51.80
3.01
-3.50
Decrease
-3.18
2LZM
L118M
65.30
5.42
-0.70
Decrease
-0.96
2LZM
L121A
51.65
3.01
-2.70
Decrease
-3.56
2LZM
L121A
51.80
3.01
-2.70
Decrease
-3.56
2LZM
L121A
65.30
5.40
-2.30
Decrease
-3.15
2LZM
L121M
65.30
5.42
-0.80
Decrease
-0.42
2LZM
L133A
40.75
2.02
-4.19
Decrease
-2.79
2LZM
L133A
51.80
3.01
-4.30
Decrease
-2.62
2LZM
L133D
51.60
3.00
-4.90
Decrease
-2.21
2LZM
L133D
61.90
6.50
-5.70
Decrease
-2.20
2LZM
L133D
64.60
4.40
-5.50
Decrease
-2.20
2LZM
L133F
41.40
1.99
-0.20
Decrease
-0.76
2LZM
L133F
52.10
2.86
-0.30
Decrease
-0.72
2LZM
L133M
65.30
5.42
-0.40
Decrease
-1.37
2LZM
M102K
47.90
10.40
-2.20
Decrease
-2.48
2LZM
M102K
51.60
3.00
-8.90
Decrease
-2.73
2LZM
M102K
65.30
5.30
-6.90
Decrease
-2.65
2LZM
M102L
51.76
3.01
-0.74
Decrease
-0.26
2LZM
M102L
64.89
5.70
-0.82
Decrease
-0.35
2LZM
M106A
51.65
3.00
-2.30
Decrease
-1.48
2LZM
M106K
47.00
3.00
-3.40
Decrease
-2.39
2LZM
M106L
47.00
3.00
0.50
Decrease
-1.01
2LZM
M120A
51.65
3.01
-0.20
Decrease
-1.01
2LZM
M120K
47.00
3.00
-1.60
Decrease
-1.89
2LZM
M120L
47.00
3.00
0.50
Decrease
0.14
2LZM
N101A
59.00
5.40
-1.50
Decrease
-1.23
2LZM
N116A
51.65
3.01
0.17
Decrease
-1.02
2LZM
N116D
40.90
2.00
-0.10
Increase
-0.65
2LZM
N116D
53.42
3.00
0.34
Increase
-0.46
2LZM
N116D
66.10
5.70
0.60
Increase
-0.32
2LZM
N116D
66.51
5.40
0.60
Increase
-0.32
2LZM
N132F
66.48
5.40
1.30
Increase
0.66
2LZM
N132I
66.48
5.40
1.20
Increase
3.20
2LZM
N132M
66.48
5.40
1.50
Increase
1.58
2LZM
N144D
40.90
2.00
-0.10
Increase
-1.09
2LZM
N144D
53.42
3.00
0.40
Increase
-1.02
2LZM
N144D
66.10
6.90
0.50
Increase
-1.13
2LZM
N144D
66.51
5.40
0.41
Increase
-1.04
2LZM
N144E
40.40
2.00
0.20
Increase
0.27
2LZM
N144E
64.50
6.50
0.50
Increase
0.42
2LZM
N144E
66.70
5.50
0.50
Increase
0.47
2LZM
N144H
39.50
2.00
-0.60
Decrease
-1.83
2LZM
N144H
62.40
6.70
0.30
Decrease
-1.46
2LZM
N163D
65.15
5.40
-0.21
Increase
0.48
2LZM
Q105A
42.00
2.10
-0.90
Decrease
-0.94
2LZM
Q105A
66.30
5.80
-0.60
Decrease
-0.61
2LZM
Q105E
42.00
2.10
-0.50
Increase
-0.61
2LZM
Q105E
66.30
5.80
-1.10
Increase
-0.48
2LZM
Q105G
42.00
2.10
-1.70
Decrease
-2.03
2LZM
Q105G
66.30
5.80
-1.50
Decrease
-2.12
2LZM
Q105M
59.00
5.40
-1.20
Decrease
0.65
2LZM
Q122A
51.65
3.01
-0.24
Decrease
0.17
2LZM
Q123A
51.65
3.01
-0.22
Increase
-0.16
2LZM
Q123E
40.40
2.00
0.30
Decrease
-0.30
2LZM
Q123E
64.50
6.50
0.40
Decrease
-0.61
2LZM
Q123E
66.70
5.50
0.10
Decrease
-0.55
2LZM
R119A
51.65
3.01
-0.18
Decrease
0.40
2LZM
R119E
50.90
2.80
-0.20
Decrease
0.33
2LZM
R119E
66.70
5.30
-0.04
Decrease
0.16
2LZM
R119H
65.15
5.40
-0.29
Decrease
-0.83
2LZM
R119M
40.90
2.00
-0.30
Decrease
-1.42
2LZM
R119M
66.10
5.70
0.10
Decrease
-1.41
2LZM
R154E
50.90
2.80
0.20
Increase
-0.37
2LZM
R154E
66.70
5.30
-1.10
Increase
-0.41
2LZM
S117A
51.65
3.01
1.27
Decrease
0.22
2LZM
S117F
51.70
3.00
1.40
Increase
1.21
2LZM
S117F
65.09
5.40
1.10
Increase
1.17
2LZM
S117F
66.48
5.40
1.10
Increase
1.17
2LZM
S117I
66.48
5.40
1.70
Increase
1.21
2LZM
S117V
66.48
5.40
2.00
Increase
1.01
2LZM
T109D
39.50
2.00
-0.30
Decrease
0.20
2LZM
T109D
62.40
6.70
0.60
Decrease
0.21
2LZM
T109N
39.50
2.00
0.00
Decrease
-0.94
2LZM
T109N
62.40
6.70
0.10
Decrease
-0.69
2LZM
T115A
51.65
3.01
-0.14
Decrease
0.00
2LZM
T115E
40.40
2.00
-0.50
Decrease
-0.12
2LZM
T115E
40.90
2.00
-0.50
Decrease
-0.12
2LZM
T115E
52.60
3.00
-0.20
Decrease
-0.04
2LZM
T115E
63.60
4.00
-0.10
Decrease
0.03
2LZM
T115E
64.60
6.50
0.30
Decrease
0.22
2LZM
T115E
66.10
6.50
0.30
Decrease
0.21
2LZM
T115E
66.70
5.50
0.00
Decrease
0.14
2LZM
T151S
65.15
5.40
0.39
Decrease
-1.77
2LZM
T152A
59.00
5.40
-1.50
Decrease
-0.58
2LZM
T152C
59.00
5.40
-0.50
Decrease
-0.35
2LZM
T152I
59.00
5.40
-0.40
Decrease
-1.61
2LZM
T152S
40.00
3.00
-2.60
Decrease
-0.27
2LZM
T152S
59.00
5.40
-2.00
Decrease
0.05
2LZM
T152V
59.00
5.40
0.20
Decrease
-1.01
2LZM
T157A
38.80
2.00
-1.10
Decrease
-2.77
2LZM
T157A
42.00
2.00
-1.40
Decrease
-2.73
2LZM
T157A
46.20
2.50
-0.90
Decrease
-2.68
2LZM
T157A
53.60
3.00
-0.50
Decrease
-2.58
2LZM
T157C
42.00
2.00
-1.30
Decrease
-1.26
2LZM
T157D
42.00
2.00
-1.10
Decrease
-1.12
2LZM
T157E
38.80
2.00
-1.50
Decrease
-0.98
2LZM
T157E
42.00
2.00
-1.50
Decrease
-0.99
2LZM
T157E
46.20
2.50
-1.30
Decrease
-0.98
2LZM
T157E
53.60
3.00
-0.80
Decrease
-0.98
2LZM
T157F
42.00
2.00
-2.40
Decrease
1.14
2LZM
T157G
42.00
2.00
-1.10
Decrease
-2.29
2LZM
T157H
42.00
2.00
-2.10
Decrease
-1.70
2LZM
T157I
38.80
2.00
-2.10
Decrease
-0.09
2LZM
T157I
42.00
2.00
-2.90
Decrease
-0.07
2LZM
T157I
46.20
2.50
-1.90
Decrease
-0.05
2LZM
T157I
53.60
3.00
-1.50
Decrease
-0.02
2LZM
T157I
62.80
4.00
-2.10
Decrease
0.02
2LZM
T157I
64.50
6.00
-1.20
Decrease
0.06
2LZM
T157L
38.80
2.00
-1.70
Decrease
-1.14
2LZM
T157L
42.00
2.00
-1.30
Decrease
-1.10
2LZM
T157L
46.20
2.50
-1.70
Decrease
-1.06
2LZM
T157L
53.60
3.00
-1.70
Decrease
-0.99
2LZM
T157N
38.80
2.00
-1.00
Decrease
-1.85
2LZM
T157N
42.00
2.00
-0.45
Decrease
-1.82
2LZM
T157N
46.20
2.50
-1.10
Decrease
-1.79
2LZM
T157N
53.60
3.00
-1.20
Decrease
-1.72
2LZM
T157R
38.80
2.00
-1.10
Decrease
-0.89
2LZM
T157R
42.00
2.00
-1.30
Decrease
-0.89
2LZM
T157R
46.20
2.50
-0.60
Decrease
-0.88
2LZM
T157R
53.60
3.00
0.30
Decrease
-0.87
2LZM
T157S
42.00
2.00
-0.66
Decrease
-2.01
2LZM
T157V
38.80
2.00
-1.70
Decrease
-0.26
2LZM
T157V
42.00
2.00
-1.60
Decrease
-0.23
2LZM
T157V
46.20
2.50
-1.60
Decrease
-0.19
2LZM
T157V
53.60
3.00
-1.20
Decrease
-0.13
2LZM
V103A
51.65
3.00
-2.20
Decrease
-1.84
2LZM
V103M
65.30
5.42
-1.20
Decrease
-1.21
2LZM
V111A
51.65
3.00
-1.30
Decrease
-2.25
2LZM
V111F
51.76
3.01
-1.43
Decrease
-2.25
2LZM
V111F
64.89
5.70
-1.69
Decrease
-2.38
2LZM
V111I
51.76
3.01
-0.69
Decrease
-0.57
2LZM
V111I
64.89
5.70
-0.85
Decrease
-0.41
2LZM
V131A
40.75
2.02
0.27
Decrease
-0.52
2LZM
V131A
40.80
2.00
0.26
Decrease
-0.52
2LZM
V131A
41.47
2.03
0.15
Decrease
-0.51
2LZM
V131A
51.10
2.83
0.30
Decrease
-0.45
2LZM
V131A
53.08
3.01
0.26
Decrease
-0.43
2LZM
V131A
53.42
3.00
0.33
Decrease
-0.43
2LZM
V131A
66.51
5.40
0.39
Decrease
-0.41
2LZM
V131D
53.08
3.01
0.08
Decrease
-0.95
2LZM
V131E
53.08
3.01
0.20
Decrease
-0.48
2LZM
V131G
53.08
3.01
-0.68
Increase
-1.12
2LZM
V131I
53.08
3.01
0.16
Increase
1.33
2LZM
V131L
53.08
3.01
0.09
Increase
0.74
2LZM
V131M
53.08
3.01
0.12
Increase
0.15
2LZM
V131S
53.08
3.01
-0.05
Decrease
-1.31
2LZM
V131T
41.47
2.03
-0.11
Increase
0.38
2LZM
V131T
51.10
2.83
-0.05
Increase
0.39
2LZM
V131T
53.08
3.01
-0.12
Increase
0.39
2LZM
V149A
51.65
3.00
-3.20
Decrease
-3.36
2LZM
V149A
59.00
5.40
-3.10
Decrease
-3.37
2LZM
V149C
40.00
3.00
-2.20
Decrease
-1.16
2LZM
V149C
59.00
5.40
-2.00
Decrease
-1.24
2LZM
V149G
59.00
5.40
-4.90
Decrease
-2.41
2LZM
V149I
59.00
5.40
-0.10
Decrease
-2.25
2LZM
V149S
59.00
5.40
-4.40
Decrease
-2.61
2LZM
V149T
51.55
3.00
-2.80
Decrease
-2.30
2LZM
V149T
59.00
5.40
-3.00
Decrease
-2.31
2RN2
A24V
50.10
3.00
0.73
Decrease
-0.91
2RN2
A24V
52.70
5.50
0.88
Decrease
-0.86
2RN2
A52C
53.00
3.20
0.80
Decrease
-0.46
2RN2
A52D
53.00
3.20
-1.90
Decrease
-1.14
2RN2
A52E
53.00
3.20
-1.50
Decrease
-1.01
2RN2
A52F
53.00
3.20
0.50
Decrease
-0.88
2RN2
A52G
53.00
3.20
-2.70
Decrease
-0.73
2RN2
A52H
53.00
3.20
-3.60
Decrease
-1.01
2RN2
A52I
53.00
3.20
1.90
Decrease
-0.93
2RN2
A52K
53.00
3.20
-5.90
Decrease
-0.52
2RN2
A52L
53.00
3.20
1.30
Decrease
-0.44
2RN2
A52M
53.00
3.20
0.50
Decrease
-1.05
2RN2
A52N
53.00
3.20
-1.80
Decrease
-0.59
2RN2
A52P
53.00
3.20
-1.60
Increase
-1.41
2RN2
A52Q
53.00
3.20
-1.20
Decrease
-0.59
2RN2
A52S
53.00
3.20
-1.80
Decrease
-0.00
2RN2
A52T
53.00
3.20
-0.80
Decrease
-1.74
2RN2
A52V
50.10
3.00
1.70
Decrease
-1.20
2RN2
A52V
53.00
3.20
1.70
Decrease
-1.18
2RN2
A52Y
53.00
3.20
-2.30
Decrease
-0.69
2RN2
D10A
47.00
9.00
4.00
Decrease
0.03
2RN2
D10A
50.00
3.00
2.40
Decrease
-0.04
2RN2
D10E
47.00
9.00
1.00
Increase
0.99
2RN2
D10E
50.00
3.00
1.10
Increase
0.90
2RN2
D10H
47.00
9.00
2.40
Decrease
-0.14
2RN2
D10H
50.00
3.00
0.40
Decrease
-0.52
2RN2
D10N
47.00
9.00
2.00
Increase
0.33
2RN2
D10N
50.00
3.00
-0.70
Decrease
0.51
2RN2
D10S
47.00
9.00
2.70
Increase
0.47
2RN2
D10S
50.00
3.00
0.70
Increase
0.19
2RN2
D70A
47.00
9.00
1.10
Decrease
-0.07
2RN2
D70A
50.00
3.00
-0.10
Decrease
0.29
2RN2
D70E
47.00
9.00
0.10
Increase
0.59
2RN2
D70E
50.00
3.00
0.50
Increase
0.57
2RN2
D70N
47.00
9.00
1.60
Decrease
-1.02
2RN2
D70N
50.00
3.00
-0.30
Decrease
-0.78
2RN2
D94E
49.80
3.00
-0.40
Increase
0.71
2RN2
D94E
49.80
5.50
-0.40
Increase
0.62
2RN2
E48A
47.00
9.00
-0.30
Decrease
0.39
2RN2
E48A
50.00
3.00
-0.10
Decrease
0.27
2RN2
E48D
47.00
9.00
-0.20
Decrease
-1.36
2RN2
E48D
50.00
3.00
0.20
Decrease
-1.45
2RN2
E48Q
47.00
9.00
0.30
Decrease
0.39
2RN2
E48Q
50.00
3.00
-0.10
Decrease
0.15
2RN2
G23A
50.10
3.00
0.70
Decrease
-1.31
2RN2
G23A
50.90
3.00
0.70
Decrease
-1.31
2RN2
G23A
52.50
5.50
0.50
Decrease
-1.23
2RN2
G23A
52.70
5.50
0.50
Decrease
-1.23
2RN2
G77A
49.80
3.00
-0.90
Decrease
-1.63
2RN2
H62D
50.10
3.00
0.67
Decrease
-0.47
2RN2
H62D
52.70
5.50
-0.17
Decrease
-0.69
2RN2
H62P
49.80
3.00
1.00
Decrease
0.02
2RN2
H62P
50.10
3.00
1.00
Decrease
0.02
2RN2
H62P
50.90
3.00
1.00
Decrease
0.02
2RN2
H62P
52.00
5.50
1.10
Decrease
-0.18
2RN2
H62P
52.50
5.50
1.10
Decrease
-0.18
2RN2
H62P
52.70
5.50
1.10
Decrease
-0.18
2RN2
H62R
50.10
3.00
-0.03
Decrease
-0.48
2RN2
H62R
52.70
5.50
0.36
Decrease
-0.73
2RN2
K91R
49.80
3.00
0.20
Increase
0.98
2RN2
K91R
49.80
5.50
0.00
Increase
0.92
2RN2
K95A
49.80
3.00
0.10
Increase
0.59
2RN2
K95A
49.80
5.50
0.10
Increase
0.48
2RN2
K95G
49.80
3.00
1.70
Increase
0.47
2RN2
K95G
49.80
5.50
1.90
Increase
0.30
2RN2
K95N
49.80
3.00
0.90
Increase
-0.19
2RN2
K95N
49.80
5.50
0.90
Increase
-0.33
2RN2
K95N
50.10
3.00
0.88
Increase
-0.19
2RN2
K95N
52.70
5.50
0.88
Increase
-0.33
2RN2
Q76L
50.10
3.00
0.24
Increase
0.86
2RN2
Q80L
50.10
3.00
0.30
Increase
0.51
2RN2
R41C
50.10
3.00
0.12
Decrease
0.06
2RN2
R41C
52.70
5.50
0.44
Decrease
-0.15
2RN2
S68A
49.80
3.00
-0.50
Decrease
-0.41
2RN2
S68G
49.80
3.00
-2.40
Decrease
-0.92
2RN2
S68L
49.80
3.00
-0.50
Increase
0.38
2RN2
S68T
49.80
3.00
-0.20
Increase
0.07
2RN2
S68V
49.80
3.00
0.60
Decrease
-0.53
2RN2
V74A
49.80
3.00
-2.20
Decrease
-1.08
2RN2
V74A
52.00
5.50
-3.40
Decrease
-1.17
2RN2
V74I
49.80
3.00
0.70
Increase
0.31
2RN2
V74I
52.00
5.50
0.60
Decrease
0.25
2RN2
V74L
49.80
3.00
1.10
Decrease
-1.65
2RN2
V74L
50.90
3.00
1.10
Decrease
-1.65
2RN2
V74L
52.00
5.50
0.90
Decrease
-1.73
2RN2
V74L
52.50
5.50
0.90
Decrease
-1.73
2RN2
A125T
49.80
3.00
0.10
Decrease
0.22
2RN2
A125T
52.00
5.50
0.00
Decrease
0.00
2RN2
D134A
47.00
9.00
2.00
Increase
0.41
2RN2
D134A
50.00
3.00
0.80
Increase
-0.11
2RN2
D134A
50.00
3.00
0.89
Increase
-0.11
2RN2
D134A
53.10
5.50
1.51
Increase
0.19
2RN2
D134E
50.00
3.00
0.72
Increase
0.50
2RN2
D134E
53.10
5.50
0.86
Increase
0.74
2RN2
D134H
50.00
3.00
0.53
Increase
-0.09
2RN2
D134H
50.90
3.00
0.50
Increase
-0.09
2RN2
D134H
52.50
5.50
1.90
Increase
0.33
2RN2
D134H
53.10
5.50
1.94
Increase
0.34
2RN2
D134I
50.00
3.00
0.69
Increase
-0.11
2RN2
D134I
53.10
5.50
1.27
Increase
0.24
2RN2
D134L
50.00
3.00
1.15
Increase
1.20
2RN2
D134L
53.10
5.50
1.51
Increase
1.47
2RN2
D134N
47.00
9.00
1.80
Increase
1.31
2RN2
D134N
50.00
3.00
-0.10
Increase
0.93
2RN2
D134N
50.00
3.00
-0.10
Increase
0.93
2RN2
D134N
53.10
5.50
0.89
Increase
1.15
2RN2
D134Q
50.00
3.00
0.48
Increase
0.91
2RN2
D134Q
53.10
5.50
1.32
Increase
1.31
2RN2
D134S
50.00
3.00
0.26
Increase
0.62
2RN2
D134S
53.10
5.50
1.08
Increase
1.02
2RN2
D134T
50.00
3.00
0.12
Increase
-0.16
2RN2
D134T
53.10
5.50
1.08
Increase
0.06
2RN2
D134V
50.00
3.00
0.31
Increase
0.76
2RN2
D134V
53.10
5.50
1.12
Increase
1.07
2RN2
E119V
50.10
3.00
0.09
Increase
0.09
2RN2
E119V
52.70
5.50
0.74
Increase
0.20
2RN2
E135K
50.10
3.00
-1.10
Increase
-0.29
2RN2
E135K
52.70
5.50
-0.22
Increase
0.03
2RN2
K117R
50.10
3.00
-0.06
Increase
-0.16
2RN2
K117R
52.70
5.50
0.03
Increase
-0.12
2RN2
Q113P
49.80
3.00
-0.20
Decrease
-1.44
2RN2
Q113P
52.00
5.50
-0.60
Decrease
-1.43
2TRX
L78K
85.32
7.00
-3.90
Decrease
-2.14
2TRX
L78R
85.32
7.00
-4.00
Decrease
-1.60
3BLS
Y150F
54.60
6.80
-0.70
Decrease
-1.10
3MBP
V8G
25.00
7.60
-1.10
Decrease
-1.66
3MBP
D55N
25.00
7.60
0.00
Decrease
-0.90
3MBP
G19C
25.00
7.60
-2.30
Decrease
-1.46
3MBP
A276G
25.00
7.60
-1.50
Decrease
-1.48
3MBP
T345I
25.00
7.60
0.70
Decrease
-1.18
3MBP
Y283D
25.00
7.60
-3.20
Decrease
-0.11
3SSI
M73A
53.36
3.20
0.54
Decrease
-0.70
3SSI
M73A
53.36
7.00
0.55
Decrease
-0.96
3SSI
M73A
53.36
9.50
0.13
Decrease
-1.05
3SSI
M73D
53.36
3.20
1.08
Decrease
-1.26
3SSI
M73D
53.36
7.00
1.60
Decrease
-1.53
3SSI
M73D
53.36
9.50
1.25
Decrease
-1.62
3SSI
M73E
53.36
3.20
0.35
Increase
0.15
3SSI
M73E
53.36
7.00
1.05
Increase
-0.10
3SSI
M73E
53.36
9.50
0.56
Increase
-0.21
3SSI
M73G
53.36
3.20
-0.21
Decrease
-2.82
3SSI
M73G
53.36
7.00
-0.06
Decrease
-3.20
3SSI
M73G
53.36
9.50
-0.49
Decrease
-3.31
3SSI
M73I
53.36
3.20
-0.73
Increase
1.73
3SSI
M73I
53.36
7.00
-0.94
Increase
1.67
3SSI
M73I
53.36
9.50
-1.28
Increase
1.63
3SSI
M73K
53.36
3.20
1.27
Decrease
-1.68
3SSI
M73K
53.36
7.00
0.35
Decrease
-1.44
3SSI
M73K
53.36
9.50
0.05
Decrease
-1.22
3SSI
M73L
53.36
3.20
-0.13
Increase
0.29
3SSI
M73L
53.36
7.00
-0.25
Decrease
0.13
3SSI
M73L
53.36
9.50
-0.55
Decrease
0.06
3SSI
M73V
53.36
3.20
-0.46
Increase
1.90
3SSI
M73V
53.36
7.00
-0.66
Increase
1.79
3SSI
M73V
53.36
9.50
-0.95
Increase
1.72
3SSI
V13A
82.21
7.00
-6.78
Decrease
-2.94
3SSI
V13A
82.21
9.50
-6.93
Decrease
-2.85
3SSI
V13F
82.21
7.00
-5.69
Decrease
-4.30
3SSI
V13F
82.21
9.50
-5.33
Decrease
-4.35
3SSI
V13G
82.21
7.00
-10.30
Decrease
-4.26
3SSI
V13G
82.21
9.50
-9.31
Decrease
-4.33
3SSI
V13I
82.21
7.00
-0.84
Decrease
-2.67
3SSI
V13I
82.21
9.50
-0.94
Decrease
-2.79
3SSI
V13L
82.21
7.00
-2.21
Decrease
-3.39
3SSI
V13L
82.21
9.50
-2.52
Decrease
-3.46
3SSI
V13M
82.21
7.00
-5.92
Decrease
-2.94
3SSI
V13M
82.21
9.50
-5.43
Decrease
-2.93
3SSI
M103A
53.36
3.20
-1.35
Decrease
-2.48
3SSI
M103A
80.70
9.50
-2.80
Decrease
-2.64
3SSI
M103A
82.21
7.00
-2.32
Decrease
-2.58
3SSI
M103G
80.70
9.50
-7.10
Decrease
-2.57
3SSI
M103G
82.21
7.00
-6.82
Decrease
-2.45
3SSI
M103I
53.36
3.20
-2.01
Decrease
-1.07
3SSI
M103I
80.70
9.50
-2.29
Decrease
-1.61
3SSI
M103I
82.21
7.00
-1.89
Decrease
-1.51
3SSI
M103L
53.36
3.20
0.77
Decrease
-1.00
3SSI
M103L
80.70
9.50
-0.29
Decrease
-1.40
3SSI
M103L
82.21
7.00
0.15
Decrease
-1.32
3SSI
M103V
53.36
3.20
-1.35
Decrease
-1.72
3SSI
M103V
80.70
9.50
-2.22
Decrease
-2.05
3SSI
M103V
82.21
7.00
-1.84
Decrease
-2.01
451C
F7A
50.40
5.00
1.10
Decrease
-2.81
451C
E43Y
50.40
5.00
0.60
Increase
0.65
451C
F34Y
50.40
5.00
1.90
Decrease
0.19
451C
Q37R
50.40
5.00
0.50
Decrease
-0.84
451C
V13M
50.40
5.00
0.40
Decrease
-0.41
451C
V78I
50.40
5.00
1.00
Increase
0.47
451C
V78I
62.60
3.60
1.11
Increase
0.69
4LYZ
F3Y
74.00
6.40
-0.45
Decrease
0.32
4LYZ
A31I
74.00
6.40
1.40
Decrease
0.41
4LYZ
A31L
74.00
6.40
1.80
Decrease
0.48
4LYZ
A31V
74.00
6.40
1.20
Decrease
0.09
4LYZ
C94A
20.00
9.50
-4.78
Decrease
-1.12
4LYZ
F34Y
74.00
6.40
0.19
Decrease
-0.18
4LYZ
G49A
65.60
2.70
-1.89
Decrease
-0.84
4LYZ
G49N
20.00
9.50
-0.96
Decrease
-3.19
4LYZ
G67A
65.60
2.70
-0.98
Decrease
-0.76
4LYZ
G71A
65.60
2.70
-0.38
Decrease
-1.14
4LYZ
H15L
74.00
6.40
0.76
Increase
1.80
4LYZ
I55A
74.00
6.40
-4.40
Decrease
-2.17
4LYZ
I55F
74.00
6.40
-2.46
Decrease
-2.12
4LYZ
I55L
74.00
6.40
-0.45
Decrease
-1.03
4LYZ
I55M
74.00
6.40
-2.27
Decrease
-1.75
4LYZ
I55T
74.00
6.40
-4.96
Decrease
-2.63
4LYZ
I55V
74.00
6.40
-0.91
Decrease
-1.16
4LYZ
K13D
20.00
9.50
-6.70
Decrease
0.44
4LYZ
M12F
66.00
2.70
0.28
Decrease
-0.84
4LYZ
M12L
66.00
2.70
-0.57
Decrease
-0.59
4LYZ
N19K
74.00
6.40
-1.06
Increase
0.26
4LYZ
N77H
74.00
6.40
-0.38
Decrease
-0.22
4LYZ
P70N
20.00
9.50
-2.15
Decrease
-1.34
4LYZ
R21Q
74.00
6.40
-0.15
Decrease
-1.30
4LYZ
R68K
74.00
6.40
-0.04
Decrease
-0.29
4LYZ
R73K
74.00
6.40
0.23
Decrease
-0.78
4LYZ
S91A
74.00
6.40
-0.15
Decrease
-1.21
4LYZ
S91D
74.00
6.40
-2.31
Increase
0.28
4LYZ
S91T
74.00
6.40
0.99
Increase
-0.80
4LYZ
S91V
74.00
6.40
-0.08
Increase
0.18
4LYZ
S91Y
74.00
6.40
-3.07
Increase
-0.43
4LYZ
T40I
74.00
6.40
-2.20
Decrease
0.18
4LYZ
T40S
74.00
6.40
-0.27
Decrease
-0.51
4LYZ
D101A
74.00
6.40
0.76
Increase
-0.17
4LYZ
D101E
74.00
6.40
0.00
Increase
1.22
4LYZ
D101F
74.00
6.40
0.72
Increase
0.73
4LYZ
D101G
74.00
6.40
0.45
Decrease
-1.01
4LYZ
D101G
74.00
6.40
0.45
Decrease
-1.01
4LYZ
D101K
74.00
6.40
0.19
Increase
0.28
4LYZ
D101N
74.00
6.40
0.04
Decrease
0.06
4LYZ
D101Q
74.00
6.40
-0.08
Increase
0.75
4LYZ
D101R
74.00
6.40
0.27
Increase
0.77
4LYZ
D101S
74.00
6.40
0.87
Increase
0.16
4LYZ
G102A
65.60
2.70
0.02
Decrease
0.02
4LYZ
G102R
74.00
6.40
0.38
Decrease
-0.67
4LYZ
G102V
74.00
6.40
-0.04
Decrease
-1.39
4LYZ
G117A
65.60
2.70
-1.46
Decrease
-1.12
4LYZ
M105T
20.00
9.50
-0.24
Decrease
-0.90
4LYZ
N103D
20.00
9.50
0.24
Decrease
-1.92
4LYZ
Q121H
74.00
6.40
-0.45
Decrease
-0.13
4LYZ
R114H
74.00
6.40
0.68
Decrease
-0.58
5CRO
A36S
45.00
3.00
0.40
Decrease
-0.89
5CRO
Q16L
45.00
3.00
2.80
Increase
-0.32
5CRO
Y26C
45.00
3.00
2.20
Increase
0.68
5CRO
Y26C
45.00
7.00
2.20
Increase
0.93
5CRO
Y26D
45.00
7.00
2.70
Increase
-1.57
5CRO
Y26F
45.00
7.00
0.40
Increase
-0.01
5CRO
Y26H
45.00
7.00
1.90
Decrease
-0.94
5CRO
Y26L
45.00
7.00
1.10
Increase
0.95
5CRO
Y26Q
45.00
7.00
1.40
Decrease
-0.85
5CRO
Y26V
45.00
7.00
0.90
Increase
0.08
5CRO
Y26W
45.00
7.00
-0.10
Increase
1.02
EYBPL
H31D
25.00
7.00
-1.60
Decrease
-1.25
EYBPL
H48N
25.00
7.00
-5.00
Decrease
-1.69
RPBPL
K4Q
51.50
8.00
0.43
Increase
0.76
RPBPL
A49V
51.50
8.00
-1.22
Increase
0.78
RPBPL
A66T
51.50
8.00
-2.99
Decrease
-0.59
RPBPL
G46A
53.40
8.00
0.66
Increase
0.17
RPBPL
G48A
53.40
8.00
0.87
Increase
0.99
RPBPL
G48N
53.40
8.00
0.79
Decrease
-0.29
RPBPL
G48S
53.40
8.00
0.68
Increase
-0.59
RPBPL
I84S
51.50
8.00
-2.25
Decrease
-3.09
RPBPL
Q33Y
51.50
8.00
1.32
Decrease
0.75
RPBPL
Q44Y
51.50
8.00
-0.02
Increase
0.08
RPBPL
Y22H
51.50
8.00
-2.25
Increase
0.42
RPBPL
Y88C
60.00
8.00
2.40
Increase
1.51
ITHUP1
E350P
50.20
6.60
0.30
Decrease
-1.01
ITHUP1
E350R
50.20
6.60
-0.30
Increase
0.16
JG0184
C83S
25.00
6.60
-1.91
Decrease
-0.98
TLBP22
E309V
88.40
7.40
-2.30
Increase
0.33
TLBP22
G177R
88.40
7.40
-2.10
Decrease
-2.19
TLBP22
G244R
88.40
7.40
-4.00
Decrease
-0.18
TLBP22
G323D
88.40
7.40
-0.40
Increase
-0.47
TLBP22
R285K
88.40
7.40
-10.30
Decrease
0.34
TLBP22
R382S
88.40
7.40
-17.40
Decrease
-2.01
TLBP22
T235I
88.40
7.40
-1.60
Increase
0.45
TSEBAT
A18G
25.00
7.80
-1.50
Decrease
-2.01
TSEBAT
A18V
25.00
7.80
0.20
Decrease
-0.38
TSEBAT
A18V
25.00
7.80
0.20
Decrease
-0.38
TSEBAT
A18V
25.00
7.80
-0.80
Decrease
-0.38
TSEBAT
C81A
50.00
9.00
-0.69
Decrease
-0.04
TSEBAT
C81G
50.00
9.00
-1.58
Decrease
-2.75
TSEBAT
C81S
50.00
9.00
-1.41
Decrease
-0.92
TSEBAT
C81V
50.00
9.00
-1.32
Decrease
0.37
TSEBAT
E49A
25.00
7.00
-0.08
Decrease
-1.04
TSEBAT
E49A
25.00
9.00
0.59
Decrease
-0.85
TSEBAT
E49C
25.00
7.00
0.01
Decrease
-0.06
TSEBAT
E49C
25.00
9.00
-0.13
Decrease
0.14
TSEBAT
E49D
25.00
7.00
-0.80
Increase
-0.12
TSEBAT
E49D
25.00
9.00
-0.03
Increase
0.06
TSEBAT
E49F
25.00
7.00
-0.86
Increase
0.48
TSEBAT
E49F
25.00
9.00
-0.02
Increase
0.74
TSEBAT
E49G
25.00
7.00
0.08
Decrease
-0.92
TSEBAT
E49G
25.00
9.00
0.60
Decrease
-0.75
TSEBAT
E49H
25.00
7.00
0.33
Decrease
-1.06
TSEBAT
E49H
25.00
9.00
0.67
Decrease
-0.72
TSEBAT
E49I
25.00
7.00
0.46
Increase
1.55
TSEBAT
E49I
25.00
9.00
1.24
Increase
1.75
TSEBAT
E49K
25.00
7.00
0.20
Decrease
-1.00
TSEBAT
E49K
25.00
9.00
0.39
Decrease
-0.64
TSEBAT
E49L
25.00
7.00
0.44
Decrease
0.07
TSEBAT
E49L
25.00
9.00
1.04
Decrease
0.28
TSEBAT
E49M
25.00
7.00
-0.05
Increase
0.23
TSEBAT
E49M
25.00
9.00
0.52
Increase
0.49
TSEBAT
E49N
25.00
7.00
-0.69
Decrease
-0.97
TSEBAT
E49N
25.00
9.00
0.27
Decrease
-0.73
TSEBAT
E49P
25.00
7.00
0.00
Increase
-0.72
TSEBAT
E49P
25.00
9.00
0.80
Increase
-0.47
TSEBAT
E49Q
25.00
7.00
-0.23
Increase
-0.38
TSEBAT
E49Q
25.00
9.00
0.54
Increase
-0.13
TSEBAT
E49S
25.00
7.00
-0.59
Decrease
-0.23
TSEBAT
E49S
25.00
9.00
0.09
Decrease
0.05
TSEBAT
E49T
25.00
7.00
-0.62
Decrease
-0.70
TSEBAT
E49T
25.00
9.00
-0.26
Decrease
-0.50
TSEBAT
E49V
25.00
7.00
0.14
Increase
1.09
TSEBAT
E49V
25.00
9.00
1.01
Increase
1.31
TSEBAT
E49W
25.00
7.00
-0.97
Increase
0.78
TSEBAT
E49W
25.00
9.00
-1.10
Increase
1.03
TSEBAT
E49Y
25.00
7.00
-0.17
Increase
-0.06
TSEBAT
E49Y
25.00
9.00
0.26
Increase
0.20
TSEBAT
C118A
50.00
9.00
-1.36
Decrease
-1.45
TSEBAT
C118S
50.00
9.00
-2.27
Decrease
-2.57
TSEBAT
C118V
50.00
9.00
-1.34
Decrease
-1.50
TSEBAT
C154A
50.00
9.00
-1.03
Decrease
-0.18
TSEBAT
C154S
50.00
9.00
-1.72
Decrease
-0.96
TSEBAT
C154V
50.00
9.00
-1.12
Decrease
-1.15
TSEBAT
F139W
23.00
7.80
0.09
Decrease
-0.28
TSEBAT
F139W
23.00
7.80
-0.07
Decrease
-0.28
TSEBAT
F258W
23.00
7.80
0.23
Decrease
-0.12
TSEBAT
F258W
23.00
7.80
-0.16
Decrease
-0.12
TSEBAT
G211D
25.00
7.80
0.20
Decrease
-1.99
TSEBAT
G211D
25.00
7.80
-0.70
Decrease
-1.99
TSEBAT
G211E
25.00
7.80
0.30
Increase
0.51
TSEBAT
G211E
25.00
7.80
0.30
Increase
0.51
TSEBAT
G211E
25.00
7.80
-0.70
Increase
0.51
TSEBAT
G211E
25.00
7.80
-0.70
Increase
0.51
TSEBAT
G211R
4.00
7.80
0.30
Decrease
-1.15
TSEBAT
G211R
4.00
7.80
-0.40
Decrease
-1.15
TSEBAT
G211S
25.00
7.80
-0.30
Decrease
-1.11
TSEBAT
G211S
25.00
7.80
-0.40
Decrease
-1.11
TSEBAT
G211V
25.00
7.80
0.20
Decrease
-0.77
TSEBAT
G211V
25.00
7.80
0.30
Decrease
-0.77
TSEBAT
G211W
25.00
7.80
-0.50
Decrease
0.14
TSEBAT
G211W
25.00
7.80
-0.70
Decrease
0.14
TSEBAT
I232V
25.00
7.80
-0.50
Decrease
-1.08
TSEBAT
I232V
25.00
7.80
-0.70
Decrease
-1.08
TSEBAT
L209V
25.00
7.80
-0.20
Decrease
-1.25
TSEBAT
L209V
25.00
7.80
-0.80
Decrease
-1.25
TSEBAT
Y175C
25.00
7.80
-0.10
Decrease
-1.02
TSEBAT
Y175C
25.00
7.80
-0.50
Decrease
-1.02
TSEBAT
Y175Q
25.00
7.80
-1.90
Decrease
-0.36
TSEBAT
Y175Q
25.00
7.80
-2.10
Decrease
-0.36

  • Protein: The PDB o PIR code of  the protein
  • Mutation: Wild type residue, residue position number and new residue
  • Temperature: in Celsius degrees
  • pH: -log[H+]
  • Exp-DDG: Experimental free energy change upon mutation. DG Unfold(Mutated)-DG Unfold(Wild-Type) in Kcal/mol
  • Pred-Stability: Predicted sign of the free enegy change
  • Pred-DDG: Predicted free energy change upon mutation in Kcal/mol